在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NRG4 Antibody, HRP conjugated

NRG4 Antibody, HRP conjugated

  • 中文名稱(chēng)：
    NRG4兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA848829LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) NRG4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DKFZp779N0541 antibody; DKFZp779N1944 antibody; Heregulin 4 antibody; HRG4 antibody; Neuregulin 4 antibody; Neuregulin-4 antibody; NRG-4 antibody; NRG4 antibody; NRG4_HUMAN antibody; pro-neuregulin-4; membrane-bound isoform antibody; Pro-NRG4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Pro-neuregulin-4, membrane-bound isoform protein (1-115AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
  • 基因功能參考文獻(xiàn)：
    1. Nrg4 is highly and preferentially expressed in healthy adipocytes, while its expression was substantially reduced in obesity. Nrg4 activated endothelial angiogenic functions and angiogenesis both in vitro and in vivo. PMID: 29902456
    2. Serum NRG4 values were significantly elevated in the Gestational Diabetes Mellitus (GDM) group compared to the control group and is associated with metabolic parameters of GDM. PMID: 29282998
    3. circulating Nrg4 concentrations are inversely associated with subclinical atherosclerosis in obese adults; circulating Nrg4 might play a role in identifying patients at high risk for cardiovascular disease PMID: 27819316
    4. The circulating Nrg4 level is elevated in the prediabetic and diabetic patients compared to control and is an independent risk factor associated with diabetes. PMID: 27862843
    5. High serum Nrg4 levels are associated with type 2 diabetes mellitus. PMID: 27329015
    6. NRG4 and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC. PMID: 25216938
    7. Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD). PMID: 26476959
    8. results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). PMID: 25401691
    9. Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival PMID: 23033483
    10. The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4. PMID: 21805036
    11. NRG4 overexpression is associated with advanced-stage prostate cancer PMID: 17545517
    12. describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide PMID: 17684490
    13. NRG4 was positive in almost all breast cancers studied. PMID: 17962208
    14. Neuregulin-4 expression is downregulated during urinary bladder cancer progression PMID: 15583696

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-4]: Secreted.
  • 蛋白家族：
    Neuregulin family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29862

    OMIM: 610894

    KEGG: hsa:145957

    STRING: 9606.ENSP00000378367

    UniGene: Hs.732438



主站蜘蛛池模板： 免费刺激性视频大片区| 亚洲成色www久久网站| 欧美疯狂性受xxxxx喷水| 无码人妻aⅴ一区二区三区玉蒲团| 九九热久久只有精品2| 久久久99久久久国产自输拍| 成人精品视频一区二区| 网友自拍区视频精品| 欧美亚洲色aⅴ大片| 亚洲精品揄拍自拍首页一| 国内最真实的xxxx人伦| 精品久久久久久无码专区| 亚洲精品国精品久久99热| 久久久精品2019免费观看| 女人国产香蕉久久精品| 一个人看的www视频免费观看| 高潮内射免费看片| av无码久久久精品免费| 97久久草草超级碰碰碰| 精品人伦一区二区三区蜜桃免费| 久久99精品国产99久久6尤物 | 凸凹人妻人人澡人人添| 日本丰满熟妇bbxbbxhd| 国产亚洲精品久久久久久入口| 人间精品视频在线播放| 国产成人免费一区二区三区| 亚洲男女羞羞无遮挡久久丫| 黑人巨大videos精品| 久久精品一区二区av999| 大陆熟妇丰满多毛xxxx| 在线 | 麻豆国产传媒61国产免费| 天堂av色综合久久天堂| 国产无遮挡又黄又爽免费视频| 国产精品无码久久久久| 国产成人无码免费视频97| 久爱无码免费视频在线| 最新亚洲人成网站在线观看| 国产成人精品日本亚洲18| 国产美女遭强高潮网站观看| 亚洲 中文字幕 日韩 无码| 国产探花在线精品一区二区|