在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Pro-neuregulin-4, membrane-bound isoform (NRG4), partial

  • 中文名稱:
    人NRG4重組蛋白
  • 貨號:
    CSB-YP848829HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NRG4重組蛋白
  • 貨號:
    CSB-EP848829HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NRG4重組蛋白
  • 貨號:
    CSB-EP848829HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NRG4重組蛋白
  • 貨號:
    CSB-BP848829HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NRG4重組蛋白
  • 貨號:
    CSB-MP848829HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    DKFZp779N0541; DKFZp779N1944; Heregulin 4; HRG4; Neuregulin 4; Neuregulin-4; NRG-4; NRG4; NRG4_HUMAN; pro-neuregulin-4; membrane-bound isoform; Pro-NRG4
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
  • 基因功能參考文獻:
    1. Nrg4 is highly and preferentially expressed in healthy adipocytes, while its expression was substantially reduced in obesity. Nrg4 activated endothelial angiogenic functions and angiogenesis both in vitro and in vivo. PMID: 29902456
    2. Serum NRG4 values were significantly elevated in the Gestational Diabetes Mellitus (GDM) group compared to the control group and is associated with metabolic parameters of GDM. PMID: 29282998
    3. circulating Nrg4 concentrations are inversely associated with subclinical atherosclerosis in obese adults; circulating Nrg4 might play a role in identifying patients at high risk for cardiovascular disease PMID: 27819316
    4. The circulating Nrg4 level is elevated in the prediabetic and diabetic patients compared to control and is an independent risk factor associated with diabetes. PMID: 27862843
    5. High serum Nrg4 levels are associated with type 2 diabetes mellitus. PMID: 27329015
    6. NRG4 and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC. PMID: 25216938
    7. Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD). PMID: 26476959
    8. results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). PMID: 25401691
    9. Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival PMID: 23033483
    10. The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4. PMID: 21805036
    11. NRG4 overexpression is associated with advanced-stage prostate cancer PMID: 17545517
    12. describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide PMID: 17684490
    13. NRG4 was positive in almost all breast cancers studied. PMID: 17962208
    14. Neuregulin-4 expression is downregulated during urinary bladder cancer progression PMID: 15583696

    顯示更多

    收起更多

  • 亞細胞定位:
    [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-4]: Secreted.
  • 蛋白家族:
    Neuregulin family
  • 數據庫鏈接:

    HGNC: 29862

    OMIM: 610894

    KEGG: hsa:145957

    STRING: 9606.ENSP00000378367

    UniGene: Hs.732438



主站蜘蛛池模板: 日韩av影院在线观看| 女人被爽到高潮视频免费国产| 特级西西人体444www高清大胆 | 99久久久无码国产精品试看| 日本道免费精品一区二区| 免费大香伊蕉在人线国产卡| 亚洲欧美在线观看| 免费特级毛片| 少妇做爰又色又紧夜视频| 一級特黃色毛片免費看| 巨人精品福利官方导航| 久久久久88色偷偷| 久久午夜私人影院| 伊人久久精品无码麻豆一区| 亚洲国产精品久久久久4婷婷| 中文在线а天堂| 欧美一区二区三区性视频| 午夜精品影视国产一区在线麻豆| 越南毛茸茸的少妇| 国产精品多人p群无码| 午夜无码福利伦利理免| 久久这里有精品国产电影网| 中文字幕一区二区三区精彩视频| 国内大量揄拍人妻精品視頻 | 久久婷婷五月综合中文字幕| 免费人成小说在线观看网站| 69精品人人人人| 中文字幕乱码一区二区三区免费| 国产精品毛片更新无码| 欧美人与动牲猛交a欧美精品| 国产精品成人网站| 一本一道色欲综合网| 国产亚洲精品成人aa片| 久久久久国产精品人妻| 国产精品99久久精品爆乳| 亚洲国产成人av片在线播放| 黑人与人妻无码中字视频| 日韩少妇内射免费播放18禁裸乳| 人妻熟人中文字幕一区二区| 天堂亚洲2017在线观看| 精品无人国产偷自产在线|