在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NRG4 Antibody, FITC conjugated

  • 中文名稱:
    NRG4兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA848829LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NRG4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DKFZp779N0541 antibody; DKFZp779N1944 antibody; Heregulin 4 antibody; HRG4 antibody; Neuregulin 4 antibody; Neuregulin-4 antibody; NRG-4 antibody; NRG4 antibody; NRG4_HUMAN antibody; pro-neuregulin-4; membrane-bound isoform antibody; Pro-NRG4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Pro-neuregulin-4, membrane-bound isoform protein (1-115AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
  • 基因功能參考文獻:
    1. Nrg4 is highly and preferentially expressed in healthy adipocytes, while its expression was substantially reduced in obesity. Nrg4 activated endothelial angiogenic functions and angiogenesis both in vitro and in vivo. PMID: 29902456
    2. Serum NRG4 values were significantly elevated in the Gestational Diabetes Mellitus (GDM) group compared to the control group and is associated with metabolic parameters of GDM. PMID: 29282998
    3. circulating Nrg4 concentrations are inversely associated with subclinical atherosclerosis in obese adults; circulating Nrg4 might play a role in identifying patients at high risk for cardiovascular disease PMID: 27819316
    4. The circulating Nrg4 level is elevated in the prediabetic and diabetic patients compared to control and is an independent risk factor associated with diabetes. PMID: 27862843
    5. High serum Nrg4 levels are associated with type 2 diabetes mellitus. PMID: 27329015
    6. NRG4 and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC. PMID: 25216938
    7. Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD). PMID: 26476959
    8. results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). PMID: 25401691
    9. Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival PMID: 23033483
    10. The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4. PMID: 21805036
    11. NRG4 overexpression is associated with advanced-stage prostate cancer PMID: 17545517
    12. describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide PMID: 17684490
    13. NRG4 was positive in almost all breast cancers studied. PMID: 17962208
    14. Neuregulin-4 expression is downregulated during urinary bladder cancer progression PMID: 15583696

    顯示更多

    收起更多

  • 亞細胞定位:
    [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-4]: Secreted.
  • 蛋白家族:
    Neuregulin family
  • 數據庫鏈接:

    HGNC: 29862

    OMIM: 610894

    KEGG: hsa:145957

    STRING: 9606.ENSP00000378367

    UniGene: Hs.732438



主站蜘蛛池模板: 国产内射爽爽大片| 大香伊蕉在人线国产最新75| 欧美日韩国产中文高清视频| 欧美天天综合色影久久精品| 久人人爽人人爽人人片av| 国产精品亚洲综合一区在线观看| 日本亚洲欧洲另类图片| 美国人性欧美xxxx| 日本熟妇浓毛hdsex| 国产精品宾馆精品酒店| 日韩成人无码v清免费| 人妻av无码中文专区久久 | 色一情一乱一伦| 海角社区在线视频播放观看| 人妻丰满熟妇无码区免费| 国产在线拍揄自揄视频网试看| 亚洲欧美日韩综合av| 无码国内精品人妻少妇蜜桃视频| 国产伦精品一区二区三区妓女下载| 久久99国产综合精品女同| 国产乱了伦视频大全亚琴影院| 艳妇乳肉豪妇荡乳av| 国产xxxx视频在线| 国产免费一区二区三区不卡| 久久一本人碰碰人碰| 亚洲国精产品一二二线| 欧美色欧美亚洲日韩在线播放| av中文无码韩国亚洲色偷偷| 超碰97人人射妻| 日本一二免费不卡区| 亚洲国产成人综合在线不卡| 强行糟蹋人妻hd中文| 艳妇臀荡乳欲伦69调教视频| 国产偷伦视频片免费视频| 三级三级久久三级久久| 性少妇无码播放| 青青草原精品99久久精品66| 国产麻豆精品福利在线观看| 激情按摩系列片aaaa| 成人片黄网站a毛片免费| 无码国产偷倩在线播放|