在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NP Antibody, HRP conjugated

Rare Species
  • 中文名稱:
    NP兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA356056LB01IFZ
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Influenza A virus NP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NP
  • 別名:
    NP antibody; Nucleoprotein antibody; Nucleocapsid protein antibody; Protein N antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Influenza A virus
  • 免疫原:
    Recombinant Influenza A virus Nucleoprotein protein (1-498AA)
  • 免疫原種屬:
    Influenza A virus
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
  • 基因功能參考文獻:
    1. Taking these observations together, TRIM41 is a constitutively expressed intrinsic influenza A virus restriction factor that targets viral NP for ubiquitination and protein degradation. PMID: 29899090
    2. Structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported. PMID: 26456934
    3. Immunoprecipitation studies revealed influenza A virus NS1 and NP as direct interaction partners of DDX3. PMID: 26792746
    4. Residue 88 of NP interacts with polymerase PB2 and contributes to influenza A virus replication. PMID: 25043584
    5. HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication. PMID: 22696656
    6. These results indicate that the PB2, PA, NP, and M segments play a more important role than the remaining four viral RNAs during the genome-packaging process. PMID: 22532680
    7. Data suggest that the flexibility of loops 1 and 2 is required for RNA sampling and binding which likely involve conformational change(s) of the nucleoprotein. PMID: 22272272
    8. These findings demonstrate that replication of the virus genome is followed by its encapsidation by NP in collaboration with its chaperone UAP56. PMID: 21507964
    9. Because the authors showed that NP lacking RNA-binding activity binds directly to the viral polymerase, it is likely that a direct interaction between NP and the viral polymerase results in a modification of the polymerase in favor of unprimed initiation. PMID: 18945782
    10. The authors identified a late-acting defect in NP that, separate from its function in RNA synthesis, indicates a role for the polypeptide in virion assembly, most likely involving M1 as a partner. PMID: 18987140
    11. respective conserved amino acids in NP may thus be critical for the assembly and/or incorporation of sets of eight viral-RNA segments PMID: 19225007

    顯示更多

    收起更多

  • 亞細胞定位:
    Virion. Host nucleus.
  • 蛋白家族:
    Influenza viruses nucleoprotein family
  • 數據庫鏈接:

    KEGG: vg:956531



主站蜘蛛池模板: 粉嫩粉嫩的18在线观看| 少妇被躁爽到高潮无码久久 | 久久国产精品萌白酱免费| 国产高潮流白浆视频| 免费观看又污又黄的网站| 中文字幕av一区二区三区人妻少妇 | 欧美日产国产精品| 欧美孕妇变态重口另类| 亚洲欧洲日产国码中文字幕| 亚洲日本乱码一区二区产线一∨| 久久久久久久99精品免费观看| 国产福利视频| 久久久久青草线蕉亚洲麻豆| 国产午夜福利在线观看视频_| 最近免费中文字幕mv在线视频3| 久久久久人妻精品一区三寸| 国产高清女同学巨大乳在线观看| 末成年女av片一区二区| 看免费真人视频网站| 日本一区二区三区免费更新不卡| 国内免费视频成人精品| 一二三四区无产乱码1000集| 国产后入清纯学生妹| 人妻少妇乱孑伦无码专区蜜柚| 色欲久久久中文字幕综合网| 国产精品无码免费播放| 在线亚洲精品国产一区麻豆| 亚洲精品国偷自产在线99人热 | 亚洲精品久久久久久久久久久| 天干夜啦天干天干国产免费| 久久99日韩国产精品久久99| 亚洲人成色77777| 无码人妻一区二区三区免费| 双腿高潮抽搐喷白浆视频| 国产男小鲜肉同志免费| 日本极品少妇xxxx| 欧美国产激情一区二区在线| 亚洲无线卡一卡二| 一区二区国产精品精华液| 国内精品久久久久影院蜜芽 | 一本无码久本草在线中文字幕dvd|