在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NP Antibody, FITC conjugated

NP Antibody, FITC conjugated

Rare Species
  • 中文名稱：
    NP兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA356056LC01IFZ
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Influenza A virus NP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NP
  • 別名：
    NP antibody; Nucleoprotein antibody; Nucleocapsid protein antibody; Protein N antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Influenza A virus
  • 免疫原：
    Recombinant Influenza A virus Nucleoprotein protein (1-498AA)
  • 免疫原種屬：
    Influenza A virus
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
  • 基因功能參考文獻：
    1. Taking these observations together, TRIM41 is a constitutively expressed intrinsic influenza A virus restriction factor that targets viral NP for ubiquitination and protein degradation. PMID: 29899090
    2. Structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported. PMID: 26456934
    3. Immunoprecipitation studies revealed influenza A virus NS1 and NP as direct interaction partners of DDX3. PMID: 26792746
    4. Residue 88 of NP interacts with polymerase PB2 and contributes to influenza A virus replication. PMID: 25043584
    5. HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication. PMID: 22696656
    6. These results indicate that the PB2, PA, NP, and M segments play a more important role than the remaining four viral RNAs during the genome-packaging process. PMID: 22532680
    7. Data suggest that the flexibility of loops 1 and 2 is required for RNA sampling and binding which likely involve conformational change(s) of the nucleoprotein. PMID: 22272272
    8. These findings demonstrate that replication of the virus genome is followed by its encapsidation by NP in collaboration with its chaperone UAP56. PMID: 21507964
    9. Because the authors showed that NP lacking RNA-binding activity binds directly to the viral polymerase, it is likely that a direct interaction between NP and the viral polymerase results in a modification of the polymerase in favor of unprimed initiation. PMID: 18945782
    10. The authors identified a late-acting defect in NP that, separate from its function in RNA synthesis, indicates a role for the polypeptide in virion assembly, most likely involving M1 as a partner. PMID: 18987140
    11. respective conserved amino acids in NP may thus be critical for the assembly and/or incorporation of sets of eight viral-RNA segments PMID: 19225007

    顯示更多

    收起更多

  • 亞細胞定位：
    Virion. Host nucleus.
  • 蛋白家族：
    Influenza viruses nucleoprotein family
  • 數據庫鏈接：

    KEGG: vg:956531



主站蜘蛛池模板： 国色天香精品一卡2卡3卡4| 奇米影视第4色| 乱熟女高潮一区二区在线| 久久国产精品成人影院 | 人妻人人澡人人添人人爽人人玩 | 欧洲熟妇色xxxxx欧美| 午夜福利免费0948视频| 国产女人乱人伦精品一区二区| 国产又大又黑又粗免费视频| 欧美日韩国产精品自在自线| 久久无码潮喷a片无码高潮| 中文字幕无码中文字幕有码a| 精品日产一卡2卡三卡4卡在线| 精品人人妻人人澡人人爽牛牛| 无码人妻一区二区三区免费看 | 漂亮人妻熟睡中被公侵犯中文版| 国产高清视频色拍| 久久精品一区二区免费播放| 无码国产精品一区二区高潮| 人妻免费一区二区三区最新| 变态另类先锋影音| 国产成人精品日本亚洲成熟| 免费精品99久久国产综合精品| 久久精品这里热有精品| 国产成人综合色视频精品| 激情综合婷婷丁香五月情| 在线观看成人无码中文av天堂| 69sex久久精品国产麻豆| 人人妻人人藻人人爽欧美一区| 国产成人影院一区二区三区| 久久国产福利播放| 欧美人与物videos另类| 日韩综合无码一区二区| 华人在线亚洲欧美精品| 久久久久久夜精品精品免费啦| 久久久噜噜噜久久| 国产a√精品区二区三区四区| 人人妻碰人人免费| 国产精品无码一区二区三区免费| 99精品国产一区二区三区 | 成人无遮挡裸免费视频在线观看|