在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NMNAT2 Antibody

NMNAT2 Antibody

  • 中文名稱：
    NMNAT2兔多克隆抗體
  • 貨號：
    CSB-PA866332HA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA866332HA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NMNAT2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C1orf15 antibody; KIAA0479 antibody; MGC2756 antibody; NaMN adenylyltransferase 2 antibody; Nicotinamide mononucleotide adenylyltransferase 2 antibody; Nicotinamide nucleotide adenylyltransferase 2 antibody; Nicotinate-nucleotide adenylyltransferase 2 antibody; NMN adenylyltransferase 2 antibody; NMNA2_HUMAN antibody; NMNAT 2 antibody; Nmnat2 antibody; PNAT 2 antibody; PNAT2 antibody; Pyridine nucleotide adenylyltransferase 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 protein (1-153AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NMNAT2 Antibody (CSB-PA866332HA01HU)，的標記方式是Non-conjugated。對于NMNAT2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA866332HB01HU NMNAT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA866332HC01HU NMNAT2 Antibody, FITC conjugated
    Biotin CSB-PA866332HD01HU NMNAT2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons.
  • 基因功能參考文獻：
    1. analyses found that rs10494561, located in the intron region within NMNAT2, was associated with the severity of the prodromal symptoms of psychosis implicitly, mediated through the volume of the left hemisphere of the superior frontal region PMID: 28544218
    2. Data indicate a chaperone function of nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2), independent from its enzymatic activity, and NMNAT2 complexes with heat shock protein 90 (HSP90) to refold aggregated protein substrates. PMID: 27254664
    3. We confirmed association at NMNAT2 and identified independent SMG7 association with systemic lupus erythematosus in European American and Amerindian/Hispanic ancestries. PMID: 26783109
    4. NMNAT2 might participate in tumorigenesis of CRC. PMID: 27218101
    5. Knockdown of NMNAT-2 significantly reduces cellular NAD(+) levels and protects cells from p53-dependent cell death upon DNA damage, suggesting an important functional role of NMNAT-2 in p53-mediated signaling. PMID: 24552824
    6. Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is essential for axon growth and survival. PMID: 24840802
    7. Overexpression of NMNAT2 in colorectal cancer cells renders them sensitive to Tiazofurin antineoplastic action. PMID: 23764899
    8. affects tau phosphorylation by regulating PP2A activity PMID: 23579329
    9. Decreased endogenous NMNAT2 function caused by reduced CREB signaling during pathological insults may be one of underlying mechanisms for neuronal death in tauopathies PMID: 22027994
    10. that overexpression of Nmnat2 in M-cells significantly delayed axon degeneration in vivo PMID: 20857515
    11. Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway. PMID: 20943658
    12. analysis of isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases PMID: 20388704
    13. cloning, isolation and kinetics PMID: 12359228
    14. Nicotinamide 5'-mononucleotide adenylyltransferase-2 is markedly expressed in the islets of Langerhans. PMID: 14516279
    15. NMNAT1 is a nuclear protein, whereas NMNAT2 and -3 are localized to the Golgi complex and the mitochondria PMID: 16118205
    16. ATP binds before NMN with Golgi apparatus NMNAT2. NMNH conversion to NADH by NMNAT1 and NMNAT3 occurs at similar rates, conversion by NMNAT2 is much slower. PMID: 17402747

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm. Cell projection, axon.
  • 蛋白家族：
    Eukaryotic NMN adenylyltransferase family
  • 組織特異性：
    Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.
  • 數據庫鏈接：

    HGNC: 16789

    OMIM: 608701

    KEGG: hsa:23057

    STRING: 9606.ENSP00000287713

    UniGene: Hs.497123



主站蜘蛛池模板： 中文成人无码精品久久久不卡| 亚洲成a人无码| 国产国拍亚洲精品av在线| 国产毛a片啊久久久久久保和丸| 亚洲中文字幕在线第二页 | 狠狠色丁香久久综合婷婷| 新国产三级视频在线播放| 无码人妻久久一区二区三区| 蜜臀av在线无码国产| 久久综合久中文字幕青草| 性一交一乱一伦一色一情孩交| 精品国产一区av天美传媒| 拍拍拍无挡免费视频| 97人摸人人澡人人人超碰| 亚洲18禁私人影院| 日韩精品无码一区二区| 日本一区二区三区免费播放视频站| 99久久久无码国产精品免费砚床| 欧美人妻一区二区三区| 亚洲欧美日韩国产综合一区二区 | 久久人人97超碰caoporen| 亚洲色丰满少妇高潮18p| 乱子轮熟睡1区| 天天狠天天透天干天天| 少妇富婆高级按摩出水高潮| 亚洲欧洲自拍拍偷午夜色| 国内精品久久久久久久久电影网| 日本老熟妇乱子伦视频| av无码av天天av天天爽| 无码一区二区波多野结衣播放搜索| 国产精品久久久久7777按摩| 久久经精品久久精品免费观看| 亚洲а∨天堂久久精品2021| 成人精品一区二区三区电影免费| 在线 国产 精品 蜜芽| 国产偷窥熟妇高潮呻吟| 久久综合色鬼综合色| 天堂在线最新版资源www| 在线视频观看免费视频18| 好男人社区资源| 亚洲欧美日韩在线资源观看|