在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NMNAT2 Antibody, FITC conjugated

NMNAT2 Antibody, FITC conjugated

  • 中文名稱：
    NMNAT2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA866332HC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NMNAT2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C1orf15 antibody; KIAA0479 antibody; MGC2756 antibody; NaMN adenylyltransferase 2 antibody; Nicotinamide mononucleotide adenylyltransferase 2 antibody; Nicotinamide nucleotide adenylyltransferase 2 antibody; Nicotinate-nucleotide adenylyltransferase 2 antibody; NMN adenylyltransferase 2 antibody; NMNA2_HUMAN antibody; NMNAT 2 antibody; Nmnat2 antibody; PNAT 2 antibody; PNAT2 antibody; Pyridine nucleotide adenylyltransferase 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 protein (1-153AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons.
  • 基因功能參考文獻(xiàn)：
    1. analyses found that rs10494561, located in the intron region within NMNAT2, was associated with the severity of the prodromal symptoms of psychosis implicitly, mediated through the volume of the left hemisphere of the superior frontal region PMID: 28544218
    2. Data indicate a chaperone function of nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2), independent from its enzymatic activity, and NMNAT2 complexes with heat shock protein 90 (HSP90) to refold aggregated protein substrates. PMID: 27254664
    3. We confirmed association at NMNAT2 and identified independent SMG7 association with systemic lupus erythematosus in European American and Amerindian/Hispanic ancestries. PMID: 26783109
    4. NMNAT2 might participate in tumorigenesis of CRC. PMID: 27218101
    5. Knockdown of NMNAT-2 significantly reduces cellular NAD(+) levels and protects cells from p53-dependent cell death upon DNA damage, suggesting an important functional role of NMNAT-2 in p53-mediated signaling. PMID: 24552824
    6. Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is essential for axon growth and survival. PMID: 24840802
    7. Overexpression of NMNAT2 in colorectal cancer cells renders them sensitive to Tiazofurin antineoplastic action. PMID: 23764899
    8. affects tau phosphorylation by regulating PP2A activity PMID: 23579329
    9. Decreased endogenous NMNAT2 function caused by reduced CREB signaling during pathological insults may be one of underlying mechanisms for neuronal death in tauopathies PMID: 22027994
    10. that overexpression of Nmnat2 in M-cells significantly delayed axon degeneration in vivo PMID: 20857515
    11. Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway. PMID: 20943658
    12. analysis of isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases PMID: 20388704
    13. cloning, isolation and kinetics PMID: 12359228
    14. Nicotinamide 5'-mononucleotide adenylyltransferase-2 is markedly expressed in the islets of Langerhans. PMID: 14516279
    15. NMNAT1 is a nuclear protein, whereas NMNAT2 and -3 are localized to the Golgi complex and the mitochondria PMID: 16118205
    16. ATP binds before NMN with Golgi apparatus NMNAT2. NMNH conversion to NADH by NMNAT1 and NMNAT3 occurs at similar rates, conversion by NMNAT2 is much slower. PMID: 17402747

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm. Cell projection, axon.
  • 蛋白家族：
    Eukaryotic NMN adenylyltransferase family
  • 組織特異性：
    Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16789

    OMIM: 608701

    KEGG: hsa:23057

    STRING: 9606.ENSP00000287713

    UniGene: Hs.497123



主站蜘蛛池模板： 太深太粗太爽太猛了视频免费观看| 无码专区 人妻系列 在线| 香蕉久久久久久久av网站| 亚洲最新无码成av人| 十八禁视频在线观看免费无码无遮挡骂过 | 人妻熟女一二三区夜夜爱| 色综合视频一区中文字幕| 亚洲精品久久久无码大桥未久| 精品日产一卡2卡三卡4卡在线| 少妇把腿扒开让我舔18| 成人3d动漫一区二区三区| 久久中文字幕无码a片不卡古代 | 男男啪啪激烈高潮cc漫画免费| 日本特黄特黄刺激大片| 久久中文字幕无码中文字幕有码| 日韩精品无码不卡无码| 好吊妞国产欧美日韩免费观看| 人人妻人人妻人人片av| 国产精品麻豆成人av网| 99久久精品费精品国产| wwww亚洲熟妇久久久久| 麻豆国产尤物av尤物在线观看| 国产美女被遭高潮免费网站| 18无码粉嫩小泬无套在线观看| 一区二区三区无码被窝影院| 亚洲综合小说另类图片五月天| 国产乱人伦av在线麻豆a | 日韩一区二区三区无码影院| 肉感饱满中年熟妇日本| 色欲香天天综合网站| 日本少妇毛茸茸高潮| 无码人妻丰满熟妇区毛片18| 美日欧激情av大片免费观看| 免费无码又爽又刺激软件下载直播| 久久亚洲精精品中文字幕| 中文日韩亚洲欧美制服| 欧美国产日韩亚洲中文| 久久亚洲精品无码va白人极品| 久久久久久a亚洲欧洲av| 尤物国精品午夜福利视频| 肉体裸交137日本大胆摄影|