在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NLGN3 Antibody, FITC conjugated

  • 中文名稱:
    NLGN3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA873703LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NLGN3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NLGN3
  • 別名:
    Gliotactin homolog antibody; HNL3 antibody; Neuroligin-3 antibody; Nlgn3 antibody; NLGN3_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Neuroligin-3 protein (642-783AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
  • 基因功能參考文獻:
    1. Wnt/beta-catenin signaling targets the trasncription of the autism-associated Neuroligin 3 gene. PMID: 29503438
    2. NLGN3 protects retinal pigment epithelium (RPE) cells and retinal ganglion cells (RGCs) from H2O2. PMID: 29792861
    3. Our data suggest that these four previously described neuroligin mutations are not primary risk factors for autism. PMID: 28948087
    4. high-grade gliomas growth depends on microenvironmental NLGN3, identify signalling cascades downstream of NLGN3 binding in glioma, and determine a therapeutically targetable mechanism of secretion PMID: 28959975
    5. e found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses. PMID: 27805570
    6. No statistically significant haplotypes have been found associated to autism in the NLGN3 after logistic regression and permutation analysis. PMID: 27782075
    7. The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust high-grade glioma cell proliferation. PMID: 25913192
    8. Our data provided a further evidence for the involvement of NLGN3 and NLGN4X gene in the pathogenesis of autism in Chinese population. PMID: 24570023
    9. The present study explores, for the first time, the contribution of NLGN3 and NLGN4X genetic variants in Greek patients with autistic disorder. PMID: 23851596
    10. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population. PMID: 23468870
    11. Neuroligins are adhesion proteins that bind to beta-neurexin to form functional synapses. PMID: 23431752
    12. Data from studies using cross-linking reagents suggest that neuroligins form dimers, including homodimers and, most notably, neuroligin 1/3 heteromers; autism-associated neuroligin mutant (neuroligin 3 R471C) forms heterodimers with neuroligin 1. PMID: 22671294
    13. study provides initial evidence that a common variant in NLGN3 gene may play a role in the etiology of ASDs among affected males in Chinese Han population. PMID: 21569590
    14. further characterization of the R451C mutation in NLGN3;role in protein folding PMID: 20227402
    15. report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders PMID: 12669065
    16. No structural variants were found in the NLGN3 gene when 96 unrelated patients with autism, 24 ADHD and 24 bipolar disorder patients were analyzed. PMID: 15622415
    17. Neuroligin mutations most probably represent rare causes of autism; it is unlikely that the allelic variants in any of these genes would be major risk factors for autism. PMID: 16077734
    18. Data indicate that coding mutations in neuroligin 3 are very rarely associated to autism spectrum disorders. PMID: 16508939
    19. Splice variants of the NLGN3 gene are associated with autism. PMID: 16648374
    20. Syntrophin-gamma2 (SNTG2) is a de novo binding partner of neuroligin 3, which correlates with autism-related mutations. PMID: 17292328
    21. no evidence for an involvement of NLGN3 and NLGN4X genetic variants with autism spectrum disorder on high functioning level PMID: 18189281
    22. these data support the hypothesis that the autism-associated NL3 mutation affects information processing in neuronal networks by altering network architecture and synchrony PMID: 19406211

    顯示更多

    收起更多

  • 相關疾病:
    Autism, X-linked 1 (AUTSX1); Asperger syndrome, X-linked, 1 (ASPGX1)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
  • 蛋白家族:
    Type-B carboxylesterase/lipase family
  • 組織特異性:
    Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
  • 數據庫鏈接:

    HGNC: 14289

    OMIM: 300336

    KEGG: hsa:54413

    STRING: 9606.ENSP00000351591

    UniGene: Hs.438877



主站蜘蛛池模板: 嫩b人妻精品一区二区三区| 亚洲va中文字幕无码一二三区| 国产av天堂亚洲国产av天堂| 欧美精品一区二区黄a片| 国产成年无码久久久久下载| 2021无码最新国产在线观看| 欧美成人家庭影院| 亚洲精品欧美精品日韩精品| 国产亚洲综合欧美视频| 精品一区二区三区在线播放视频| 少妇粉嫩小泬喷水视频www| 亚洲最大av无码国产| 国产精品人妻久久毛片高清无卡| 护士奶头又大又软又好摸| 国产精品中文久久久久久久| 国产精品久久久久久久久久久久| 久在线精品视频线观看| 满春阁精品a∨在线观看| 亚洲成a人片在线观看的电影| 免费毛儿一区二区十八岁| 精品少妇人妻av一区二区三区| 亚洲乱码日产精品bd在线看 | 国产成人夜色高潮福利影视| 国产在线精品二区| 亚洲五月综合缴情在线| 亚洲无线观看国产精品| 日日日日做夜夜夜夜做无码| 久久久中日ab精品综合| 亚洲午夜成人片| 少妇厨房愉情理9仑片视频| 精品乱码无人区一区二区 | 国产三级做爰在线播放| 久久精品免费一区二区| 成人免费b2b网站大全在线| 97成人精品区在线播放| 欧美精品videossex少妇| 国产精品vⅰdeoxxxx国产| 尤物国精品午夜福利视频| 国产精品人妻一码二码| 无码国产精品一区二区免费式影视 | 久久精品成人免费国产片小草|