在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NLGN3 Antibody, Biotin conjugated

  • 中文名稱:
    NLGN3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA873703LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) NLGN3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NLGN3
  • 別名:
    Gliotactin homolog antibody; HNL3 antibody; Neuroligin-3 antibody; Nlgn3 antibody; NLGN3_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Neuroligin-3 protein (642-783AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
  • 基因功能參考文獻(xiàn):
    1. Wnt/beta-catenin signaling targets the trasncription of the autism-associated Neuroligin 3 gene. PMID: 29503438
    2. NLGN3 protects retinal pigment epithelium (RPE) cells and retinal ganglion cells (RGCs) from H2O2. PMID: 29792861
    3. Our data suggest that these four previously described neuroligin mutations are not primary risk factors for autism. PMID: 28948087
    4. high-grade gliomas growth depends on microenvironmental NLGN3, identify signalling cascades downstream of NLGN3 binding in glioma, and determine a therapeutically targetable mechanism of secretion PMID: 28959975
    5. e found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses. PMID: 27805570
    6. No statistically significant haplotypes have been found associated to autism in the NLGN3 after logistic regression and permutation analysis. PMID: 27782075
    7. The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust high-grade glioma cell proliferation. PMID: 25913192
    8. Our data provided a further evidence for the involvement of NLGN3 and NLGN4X gene in the pathogenesis of autism in Chinese population. PMID: 24570023
    9. The present study explores, for the first time, the contribution of NLGN3 and NLGN4X genetic variants in Greek patients with autistic disorder. PMID: 23851596
    10. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population. PMID: 23468870
    11. Neuroligins are adhesion proteins that bind to beta-neurexin to form functional synapses. PMID: 23431752
    12. Data from studies using cross-linking reagents suggest that neuroligins form dimers, including homodimers and, most notably, neuroligin 1/3 heteromers; autism-associated neuroligin mutant (neuroligin 3 R471C) forms heterodimers with neuroligin 1. PMID: 22671294
    13. study provides initial evidence that a common variant in NLGN3 gene may play a role in the etiology of ASDs among affected males in Chinese Han population. PMID: 21569590
    14. further characterization of the R451C mutation in NLGN3;role in protein folding PMID: 20227402
    15. report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders PMID: 12669065
    16. No structural variants were found in the NLGN3 gene when 96 unrelated patients with autism, 24 ADHD and 24 bipolar disorder patients were analyzed. PMID: 15622415
    17. Neuroligin mutations most probably represent rare causes of autism; it is unlikely that the allelic variants in any of these genes would be major risk factors for autism. PMID: 16077734
    18. Data indicate that coding mutations in neuroligin 3 are very rarely associated to autism spectrum disorders. PMID: 16508939
    19. Splice variants of the NLGN3 gene are associated with autism. PMID: 16648374
    20. Syntrophin-gamma2 (SNTG2) is a de novo binding partner of neuroligin 3, which correlates with autism-related mutations. PMID: 17292328
    21. no evidence for an involvement of NLGN3 and NLGN4X genetic variants with autism spectrum disorder on high functioning level PMID: 18189281
    22. these data support the hypothesis that the autism-associated NL3 mutation affects information processing in neuronal networks by altering network architecture and synchrony PMID: 19406211

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Autism, X-linked 1 (AUTSX1); Asperger syndrome, X-linked, 1 (ASPGX1)
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
  • 蛋白家族:
    Type-B carboxylesterase/lipase family
  • 組織特異性:
    Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14289

    OMIM: 300336

    KEGG: hsa:54413

    STRING: 9606.ENSP00000351591

    UniGene: Hs.438877



主站蜘蛛池模板: 久久国产精品萌白酱免费| 大胆欧美熟妇xx| 影音先锋亚洲成aⅴ人在| 国产精品99精品无码视亚| 全部孕妇毛片| 亚洲va在线va天堂xxxx中文| 久久久精品妇女99| 色八区人妻在线视频免费| 大胸美女被吃奶爽死视频| 黑人大群体交免费视频| 人妻被按摩师玩弄到潮喷| 中文字幕中文有码在线| 成人爽a毛片在线视频| 午夜不卡av免费| 亚洲精品久久久久久一区二区 | 国产肉体xxxx裸体137大胆| 久久综合九色综合97婷婷| 日韩欧无码一二三区免费不卡| 亚洲爆乳成av人在线蜜芽| 东京热大乱系列无码| 久久成人a毛片免费观看网站| 国产精品熟妇视频国产偷人| 亚洲精品久久一区二区三区四区| 欧美自拍亚洲综合丝袜| 真正免费毛片在线播放| 影音先锋无码aⅴ男人资源站| 美女张开腿让男人桶爽| 婷婷丁香五月六月综合激情啪| 无码人妻斩一区二区三区| 亚洲国产精华液网站w| 国产精品乱码一区二区三区| 色伊人亚洲综合网站| 久热爱精品视频线路一 | 精品无码一区二区三区爱欲| 欧洲 亚洲 国产图片综合| 国产高清在线a免费视频观看| 日韩一区二区a片免费观看| 丰满少妇被粗大的猛烈进出视频| 无码人妻少妇久久中文字幕蜜桃 | 少妇人妻偷人激情视频| 成年无码av片在线|