在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NLGN1 Antibody

  • 中文名稱:
    NLGN1兔多克隆抗體
  • 貨號:
    CSB-PA928711
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA928711(NLGN1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NLGN1
  • 別名:
    NLG 1 antibody; KIAA1070 antibody; MGC45115 antibody; Neuroligin-1 antibody; NL1 antibody; NLG1 antibody; Nlgn1 antibody; NLGN1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Fusion protein of Human NLGN1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development.
  • 基因功能參考文獻:
    1. Findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD. PMID: 27219346
    2. We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD PMID: 28841651
    3. the expression of NL1 and its binding partner neurexin-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats. PMID: 25428619
    4. Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation. PMID: 26440732
    5. NLGN1 was associated with schizophrenia in Chinese Han Populations PMID: 26674772
    6. Increasing expression of TGF-beta1 protein, decreasing expressions of Ghrelin, Neurexin, and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal PMID: 25399301
    7. Neuroligin-1 and Glu may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of Hirschsprung's disease. PMID: 26109803
    8. Results indicate that the neurexin and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia. PMID: 26078884
    9. Monitoring the attachment and detachment of neurexin (Nrx)-coated quantum dots measures the rates of neurexin (Nrx)/neuroligin interaction in the hippocampus. PMID: 23853109
    10. We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes PMID: 23929743
    11. Expression levels of neurexin and neuroligin in ENS are significantly down-regulated in HSCR, which may be involved in the pathogenesis of HSCR. PMID: 23264101
    12. these manipulations of NL1 function illuminate the significance of NL1 intracellular signaling in vivo, and enhance our understanding of the factors that gate the maturation of glutamatergic synapses and complex behavior PMID: 23719805
    13. Amyloid beta-peptide binds to the extracellular domain of neuroligin-1 with a K(d) in the nanomolar range. PMID: 21838267
    14. glycosylation processing of neuroligin, in addition to mRNA splicing and gene selection, contributes to the specificity of the neurexin-beta/neuroligin-1 association PMID: 14522992
    15. the neurexin 1beta/neuroligin 1 complex has a role in synapse formation PMID: 15797875
    16. Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins. PMID: 16882988
    17. Neuroligin-1 performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities. PMID: 19730411

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cleft. Cell junction, synapse, synaptic cell membrane.
  • 蛋白家族:
    Type-B carboxylesterase/lipase family
  • 組織特異性:
    Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells.
  • 數據庫鏈接:

    HGNC: 14291

    OMIM: 600568

    KEGG: hsa:22871

    STRING: 9606.ENSP00000354541

    UniGene: Hs.478289



主站蜘蛛池模板: 久久久久女人精品毛片| 无码视频一区二区三区在线观看 | 狠狠热精品免费视频| 日本丰满妇人成熟免费中文字幕| 99久久免费国产精品| 亚洲欧洲美洲在线观看| 国产成人精品日本亚洲专区61| 国产精品国产三级国产普通话| 草草影院精品一区二区三区| 浪货趴办公桌~h揉秘书电影| 国产一区二区内射最近更新| 久久人妻无码中文字幕| 97se亚洲综合自在线| 国产成人高清精品亚洲| 国产精品人妻一区二区三区四 | 亚洲国产成人综合精品| 人人妻人人爽人人澡欧美一区| 最近2019中文字幕在线| 日韩国产人妻一区二区三区 | 精品少妇无码av无码专区| 亚洲三区在线观看内射后入| 疯狂迎合进入强壮公的视频| 嫩草伊人久久精品少妇av| 久久99精品国产麻豆| 久久精品国产首页027007| 国产成人8x人网站在线视频| 无码高潮爽到爆的喷水视频| 国产欧美日韩国产高清| 久久久久国产精品人妻aⅴ天堂| 色婷婷亚洲精品综合影院| 亚洲欭美日韩颜射在线二| 久久精品中文字幕大胸| 久热这里只有精品99在线观看| 被黑人猛躁10次高潮视频| 丁香色婷婷国产精品视频| 午夜精品久久久久久久四虎| 亚洲精品色情app在线下载观看| 亚洲国产成人乱码| 亚洲电影天堂av2017| 97免费人妻在线视频| 久久久久久人妻无码|