在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NLGN1 Antibody, Biotin conjugated

  • 中文名稱:
    NLGN1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA839786LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) NLGN1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NLGN1
  • 別名:
    NLG 1 antibody; KIAA1070 antibody; MGC45115 antibody; Neuroligin-1 antibody; NL1 antibody; NLG1 antibody; Nlgn1 antibody; NLGN1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Neuroligin-1 protein (51-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development.
  • 基因功能參考文獻:
    1. Findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD. PMID: 27219346
    2. We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD PMID: 28841651
    3. the expression of NL1 and its binding partner neurexin-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats. PMID: 25428619
    4. Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation. PMID: 26440732
    5. NLGN1 was associated with schizophrenia in Chinese Han Populations PMID: 26674772
    6. Increasing expression of TGF-beta1 protein, decreasing expressions of Ghrelin, Neurexin, and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal PMID: 25399301
    7. Neuroligin-1 and Glu may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of Hirschsprung's disease. PMID: 26109803
    8. Results indicate that the neurexin and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia. PMID: 26078884
    9. Monitoring the attachment and detachment of neurexin (Nrx)-coated quantum dots measures the rates of neurexin (Nrx)/neuroligin interaction in the hippocampus. PMID: 23853109
    10. We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes PMID: 23929743
    11. Expression levels of neurexin and neuroligin in ENS are significantly down-regulated in HSCR, which may be involved in the pathogenesis of HSCR. PMID: 23264101
    12. these manipulations of NL1 function illuminate the significance of NL1 intracellular signaling in vivo, and enhance our understanding of the factors that gate the maturation of glutamatergic synapses and complex behavior PMID: 23719805
    13. Amyloid beta-peptide binds to the extracellular domain of neuroligin-1 with a K(d) in the nanomolar range. PMID: 21838267
    14. glycosylation processing of neuroligin, in addition to mRNA splicing and gene selection, contributes to the specificity of the neurexin-beta/neuroligin-1 association PMID: 14522992
    15. the neurexin 1beta/neuroligin 1 complex has a role in synapse formation PMID: 15797875
    16. Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins. PMID: 16882988
    17. Neuroligin-1 performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities. PMID: 19730411

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cleft. Cell junction, synapse, synaptic cell membrane.
  • 蛋白家族:
    Type-B carboxylesterase/lipase family
  • 組織特異性:
    Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14291

    OMIM: 600568

    KEGG: hsa:22871

    STRING: 9606.ENSP00000354541

    UniGene: Hs.478289



主站蜘蛛池模板: 国产成人无码www免费视频播放| 波多野成人无码精品电影| 最近中文字幕mv在线视频看 | 99偷拍视频精品一区二区| 成 人片 黄 色 大 片| 日韩 无码 偷拍 中文字幕| 亚洲国产欧美一区二区好看电影| 狠狠狠色丁香综合婷婷久久| av无码久久久久不卡网站下载 | 国产又粗又大又黄| 老太婆性杂交视频| 国产午夜大地久久| 日韩一区二区三区射精| 欧美另类bbbxxxxx另类| 精品国产av一二三四区| 亚洲中文字幕无码一区在线| 久久精品2021国产| 亚洲爆乳成av人在线视菜奈实| 51福利国产在线观看午夜天堂 | 1000部拍拍拍18勿入免费视频下载| 无码av中文一区二区三区桃花岛| 日韩插啊免费视频在线观看| 天堂岛国av无码免费无禁网站| 吃奶呻吟张开双腿做受在线播放| 激情内射亚洲一区二区三区爱妻| 日躁夜躁狠狠躁2001| 亚洲日本在线在线看片| 精品免费国产一区二区三区四区介绍 | 国产精品卡1卡2卡3网站| 无码av永久免费专区麻豆| 日本精品人妻无码77777| 亚洲精品tv久久久久久久久久| 一区二区三区高清日本vr| 国产明星裸体xxxx视频| 色综亚洲国产vv在线观看| 中文字幕日韩精品无码内射| 无码人妻巨屁股系列| 免费毛儿一区二区十八岁| 亚洲国产成人综合精品| 伊人久久大香线蕉综合直播| 999久久久精品国产消防器材|