在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NIN Antibody

  • 中文名稱:
    NIN兔多克隆抗體
  • 貨號:
    CSB-PA843155LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA843155LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NIN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Centrosome Marker antibody; Glycogen synthase kinase 3 beta interacting protein antibody; GSK3B interacting protein antibody; h Glycogen synthase kinase 3 beta-interacting protein antibody; hNinein antibody; KIAA1565 antibody; NIN antibody; NIN protein antibody; NIN_HUMAN antibody; ninein (GSK3B interacting protein) antibody; Ninein antibody; Ninein centrosomal protein antibody; SCKL7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ninein protein (80-185AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,NIN Antibody (CSB-PA843155LA01HU),的標記方式是Non-conjugated。對于NIN Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA843155LB01HU NIN Antibody, HRP conjugated ELISA
    FITC CSB-PA843155LC01HU NIN Antibody, FITC conjugated
    Biotin CSB-PA843155LD01HU NIN Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole.
  • 基因功能參考文獻:
    1. Our analyses suggest a relationship with prenatal neurogenesis and identify the human data point as an outlier, possibly explained by postnatal changes in development on the human lineage. PMID: 22937743
    2. Ninein influences the rate of axonal growth and branching by affecting microtubule stability and dynamics. PMID: 25741725
    3. JAK2 Tyrosine Kinase phosphorylates centrosomal protein ninein, which negatively regulates it PMID: 25332239
    4. A Ninein (NIN) missense mutation identified in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. PMID: 23665482
    5. The role of hNinein isoform 6 expression in cell differentiation was assessed in BrdU-treated IMR-32 cells PMID: 23047184
    6. The prevalence of hNinein autoreactivity and its specificity in 22 rheumatoid arthritis and 32 systemic lupus erythematosus autoimmune disease sera. PMID: 21667027
    7. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. PMID: 21325031
    8. Two single nucleotide polymorphisms in the APC and NIN loci were significantly associated with pancreatic cancer risk PMID: 20056645
    9. Ninein is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC. PMID: 11956314
    10. ninein protein has two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle PMID: 12927815
    11. Elevated ninein causes mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules, suggesting a regulatory role for ninein in microtubule nucleation. PMID: 15190203
    12. We propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome. PMID: 15784680
    13. our findings place SUMOylation target on the centrosome structure protein, hNinein, which results in the switch localization from centrosome to nucleus PMID: 16154161
    14. analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin PMID: 17102634
    15. hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity. PMID: 17383637
    16. Data show that ninein is highly dynamic and that, in epithelial cells, it is present not only at the centrosome but also in the cytoplasm as distinct speckles. PMID: 17698918

    顯示更多

    收起更多

  • 相關疾病:
    Seckel syndrome 7 (SCKL7)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.; [Isoform 6]: Cytoplasm.
  • 組織特異性:
    Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5.
  • 數據庫鏈接:

    HGNC: 14906

    OMIM: 608684

    KEGG: hsa:51199

    STRING: 9606.ENSP00000371472

    UniGene: Hs.310429



主站蜘蛛池模板: 日本高清色倩视频在线观看| 天堂在线www资源在线| 色播亚洲视频在线观看| 欧美亚洲国产精品久久| 亚洲国产成人超a在线播放| 亚洲偷精品国产五月丁香麻豆| 国产成人综合日韩精品无码不卡| 国产在线观看无码免费视频| 亚洲日韩欧洲乱码av夜夜摸| 中文字幕无线码免费人妻| 欧美18精品久久久无码午夜福利| 国产亚洲香蕉线播放αv38| 国产草莓视频无码a在线观看| 亚洲成av人片在线观看下载| 久久综合九色综合欧美98| 大肉大捧一进一出好爽视频动漫| 人妻丰满熟妇av无码片| 亚洲成av人片在线观看橙子| 亚洲国产精品毛片av不卡在线| 成年丰满熟妇午夜免费视频| 国产白浆喷水在线视频| 少妇高潮惨叫久久久久电影| 美女内射毛片在线看3d| 暖暖视频日本在线观看| 特黄做受又硬又粗又大视频小说| 日本少妇三级hd激情在线观看| 国产av天堂亚洲国产av麻豆| 亚洲视频一区| 国产高清av首播原创麻豆| 国产成人精品久久一区二区三区| 日韩一区二区三免费高清| 午夜影视免费| 欧美激情综合色综合啪啪五月| 日本妇人成熟免费中文字幕| 最近最新中文字幕高清免费| 好爽别插了无码视频| 无码专区 丝袜美腿 制服师生| 精品伊人久久久大香线蕉下载| 国产午夜成人久久无码一区二区 | 亚洲天堂2017无码中文| 狠狠噜天天噜日日噜色综合|