在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NIN Antibody, HRP conjugated

  • 中文名稱:
    NIN兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA843155LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NIN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Centrosome Marker antibody; Glycogen synthase kinase 3 beta interacting protein antibody; GSK3B interacting protein antibody; h Glycogen synthase kinase 3 beta-interacting protein antibody; hNinein antibody; KIAA1565 antibody; NIN antibody; NIN protein antibody; NIN_HUMAN antibody; ninein (GSK3B interacting protein) antibody; Ninein antibody; Ninein centrosomal protein antibody; SCKL7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ninein protein (80-185AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole.
  • 基因功能參考文獻:
    1. Our analyses suggest a relationship with prenatal neurogenesis and identify the human data point as an outlier, possibly explained by postnatal changes in development on the human lineage. PMID: 22937743
    2. Ninein influences the rate of axonal growth and branching by affecting microtubule stability and dynamics. PMID: 25741725
    3. JAK2 Tyrosine Kinase phosphorylates centrosomal protein ninein, which negatively regulates it PMID: 25332239
    4. A Ninein (NIN) missense mutation identified in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. PMID: 23665482
    5. The role of hNinein isoform 6 expression in cell differentiation was assessed in BrdU-treated IMR-32 cells PMID: 23047184
    6. The prevalence of hNinein autoreactivity and its specificity in 22 rheumatoid arthritis and 32 systemic lupus erythematosus autoimmune disease sera. PMID: 21667027
    7. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. PMID: 21325031
    8. Two single nucleotide polymorphisms in the APC and NIN loci were significantly associated with pancreatic cancer risk PMID: 20056645
    9. Ninein is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC. PMID: 11956314
    10. ninein protein has two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle PMID: 12927815
    11. Elevated ninein causes mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules, suggesting a regulatory role for ninein in microtubule nucleation. PMID: 15190203
    12. We propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome. PMID: 15784680
    13. our findings place SUMOylation target on the centrosome structure protein, hNinein, which results in the switch localization from centrosome to nucleus PMID: 16154161
    14. analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin PMID: 17102634
    15. hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity. PMID: 17383637
    16. Data show that ninein is highly dynamic and that, in epithelial cells, it is present not only at the centrosome but also in the cytoplasm as distinct speckles. PMID: 17698918

    顯示更多

    收起更多

  • 相關疾病:
    Seckel syndrome 7 (SCKL7)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.; [Isoform 6]: Cytoplasm.
  • 組織特異性:
    Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5.
  • 數據庫鏈接:

    HGNC: 14906

    OMIM: 608684

    KEGG: hsa:51199

    STRING: 9606.ENSP00000371472

    UniGene: Hs.310429



主站蜘蛛池模板: 色欲一区二区三区精品a片| 亚洲国产精品久久久久网站| 午夜福利不卡片在线机免费视频 | 中文字幕久久精品一区二区三区| 欧美孕妇乳喷奶水在线观看| 真人做受试看120分钟小视频| 极品粉嫩福利午夜在线播放| 国产乱子伦60女人的皮视频| 九九热爱视频精品视频| 亚洲 另类 熟女 字幕| 日本老妇人乱xxy| 亚洲欧洲av一区二区久久| 激情文学小说区另类小说同性| 天堂8在线天堂资源bt| 国产熟妇久久777777| 中文字幕人妻熟女人妻洋洋| 新版天堂资源中文www连接| av区无码字幕中文色| 国产伦精品一区二区三区免.费 | 国产伦理一区二区| 中文字幕日本最新乱码视频| 亚洲中文字幕av每天更新| 国产午夜成人免费看片app| 丰满熟女人妻中文字幕免费 | 正在播放酒店约少妇高潮| 亚洲精品久久久久午夜福禁果tⅴ 国产精品无码久久久久久 | 成人片黄网站色大片免费| 精品久久一区二区乱码| 中文字幕人妻偷伦在线视频| 久久精品aⅴ无码中文字字幕蜜桃 午夜成人鲁丝片午夜精品 | 国产日韩另类综合11页| 丁香婷婷六月综合交清| 久久久久99精品成人片| 国产精品sp调教打屁股| 拍国产乱人伦偷精品视频| 熟妇人妻一区二区三区四区 | 无码无遮挡又大又爽又黄的视频| 日本看片一二三区高清| 亚洲国产欧美在线人成aaaa| 少妇人妻系列无码专区视频| 亚洲中文字幕日产无码成人片|