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  4. NFKBIL1 Antibody, Biotin conjugated

NFKBIL1 Antibody, Biotin conjugated

  • 中文名稱：
    NFKBIL1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA887001LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NFKBIL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NFKBIL1
  • 別名：
    NFKBIL1 antibody; IKBL antibody; NF-kappa-B inhibitor-like protein 1 antibody; Inhibitor of kappa B-like protein antibody; I-kappa-B-like protein antibody; IkappaBL antibody; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human NF-kappa-B inhibitor-like protein 1 protein (185-312AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.
  • 基因功能參考文獻(xiàn)：
    1. genetic association studies in a population of black women in South Africa: Data suggest that an SNP in NFKBIL1 (rs2071592) is associated with iron status/iron-deficiency anemia in the population studied. PMID: 25809685
    2. These observations suggest a functional involvement of IkappaBL in the regulation of alternative splicing in both human and viral genes, which is a novel link of HLA locus to the regulation of immunity and infection in humans. PMID: 23953137
    3. an association was noted between IKBL-62T and idiopathic inflammatory myopathy, with increased risk noted in anti-Jo-1- and -PM-Scl antibody-positive patients; the IKBL-62T association is dependent on TNF-308A and HLA-B*08, due to strong shared linkage disequilibrium between these alleles PMID: 22210660
    4. results do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample. PMID: 19578685
    5. Results of the present study do not provide evidence for the association between the NFKBIL1 exon 4 polymorphism and MS predisposition in the investigated Polish population. PMID: 20568399
    6. The DPB1 gene controlled the severity of the vascular lesion, whereas the IKBL gene (NFKBIL1) was associated with a relatively mild phenotype. PMID: 19165231
    7. identifed the second rheumatoid arthritis -susceptibility locus within the HLA region, as the T allele of SNP 96452 (T/A), in the promoter region (position -62) of the I kappa BL gene (P=.0062) PMID: 12509789
    8. study shows that the estimated haplotype IkBL -421 8T/-62 T tends to be associated with susceptibility to rheumatoid arthritis in Taiwan PMID: 16644022
    9. no association between polymorphisms and hypertension, myocardial infarct and angina in Irish PMID: 17485095
    10. Minor homozygous genotypes of polymorphisms in NFKBIL1 were associated with moderately protective effects against myocardial infarction. PMID: 17517687
    11. The IKBL locus itself or another critical gene in this region may confer susceptibility to the development of chronic Chagas cardiomyopathy. PMID: 17544510
    12. IL1RN VNTR and the IKBL + 738T > C gene polymorphisms are not risk factors for myocardial infarct in Caucasians with type 2 diabetes PMID: 17847930
    13. A potential role for NFkBL1 in the pathogenesis of rheumatoid arthritis and in mRNA processing or the regulation of translation. PMID: 17855452
    14. IkappaBL allele polymorphisms influences risk of acquiring systemic lupus erythematosus and Sjogren's syndrome. PMID: 18295675

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  • 相關(guān)疾病：
    Rheumatoid arthritis (RA)
  • 亞細(xì)胞定位：
    Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.
  • 組織特異性：
    Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7800

    OMIM: 180300

    KEGG: hsa:4795

    STRING: 9606.ENSP00000365318

    UniGene: Hs.2764



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