在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NEU4 Antibody

NEU4 Antibody

  • 中文名稱：
    NEU4兔多克隆抗體
  • 貨號：
    CSB-PA848831LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA848831LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA848831LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA848831LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NEU4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    NEU4 antibody; LP5125Sialidase-4 antibody; EC 3.2.1.18 antibody; N-acetyl-alpha-neuraminidase 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Sialidase-4 protein (225-377AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NEU4 Antibody (CSB-PA848831LA01HU)，的標記方式是Non-conjugated。對于NEU4 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA848831LB01HU NEU4 Antibody, HRP conjugated ELISA
    FITC CSB-PA848831LC01HU NEU4 Antibody, FITC conjugated
    Biotin CSB-PA848831LD01HU NEU4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose.
  • 基因功能參考文獻：
    1. The most potent compound tested targeted the human Neu4 isoenzyme, and was able to substantially reduce the rate of cell migration. We found that the lateral mobility of integrins was reduced by treatment of cells with Neu3, suggesting that Neu3 enzyme activity resulted in changes to integrin-co-receptor or integrin-cytoskeleton interactions PMID: 27344026
    2. The silencing or chemical inhibition of NEU4 changes the entire glycosylation pattern of proteins and lipids, making it more similar to that of differentiated GBM cells and drastically reduces GSCs survival. PMID: 25144716
    3. The results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt. PMID: 24030392
    4. Overexpression of NEU4 is associated with neuroblastoma. PMID: 22287118
    5. NEU4 is involved in regulation of neuronal function by polySia degradation in mammals. PMID: 22393058
    6. NEU4 plays an important role in control of sialyl Lewis antigen expression and its impairment in colon cancer PMID: 21521691
    7. The NEU4 long form localizes in mitochondria, while the short form is also associated with the endoplasmic reticulum. PMID: 19797320
    8. The NEU4 gene, identified by searching sequence databases for entries showing homologies to the human cytosolic sialidase NEU2, maps in 2q37 and encodes a 484-residue protein. PMID: 14962670
    9. Neu4 is a novel human lysosomal lumen sialidase PMID: 15213228
    10. Data show that the differentiation of monocytes into macrophages is associated with regulation of the expression of at least three distinct cellular sialidases, Neu1, 3, and 4, with specific up-regulation of the enzyme activity of only Neu1. PMID: 15885103
    11. related to malignancy and may be potential targets for cancer diagnosis and therapy PMID: 18651674

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cell projection, neuron projection.; [Isoform 2]: Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.
  • 蛋白家族：
    Glycosyl hydrolase 33 family
  • 組織特異性：
    [Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon.; [Isoform 2]: Highly expressed in brain and at lower levels in kidney and liver.
  • 數據庫鏈接：

    HGNC: 21328

    OMIM: 608527

    KEGG: hsa:129807

    STRING: 9606.ENSP00000320318

    UniGene: Hs.551747



主站蜘蛛池模板： 欧美日韩一本的免费高清视频| 欧美牲交a欧美牲交aⅴ图片| 色v99在线影院| 99精品久久久久中文字幕| 国产欧美亚洲精品a第一页| 亚洲国产精品成人久久| 青春草在线视频免费观看 | 久99视频精品免费观看福利| 久久精品国产成人午夜福利| 伊人成色综合网 | a国产在线v的不卡视频| 人人婷婷人人澡人人爽| av无码一区二区大桥未久| 可以直接看的无码av| 四虎国产精品亚洲一区久久特色| 韩国三级hd中文字幕叫床| 国产三级a三级三级| 久久这里只精品国产免费10| 国产精品亚洲精品日韩己满十八小 | 军人粗大的内捧猛烈进出视频| 少妇av一区二区三区无码| 国产成人精品午夜福利在线观看| 日本老熟妇乱子伦视频| 高清视频在线观看一区二区三区| 伊人久久大香线蕉av一区二区| 久久九九精品国产综合喷水| 国内自拍久久久久影院| 熟女人妻aⅴ一区二区三区60路| 国产女人高潮视频在线观看 | 日本丰满少妇bbb| 国产成人精品亚洲线观看| 日本精品一区二区三区四区| 97se狠狠狠狠狼鲁亚洲综合色| 热re99久久精品国产99热| 亚洲欧美国产精品久久久久久久| 国产成人片无码免费视频| 东京热人妻丝袜无码av一二三区观| 久久国产精品无码一区二区三区| 日本道色综合久久影院| 国产成人av乱码免费观看| 国产精品无码v在线观看|