在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NEU4 Antibody, FITC conjugated

  • 中文名稱:
    NEU4兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA848831LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NEU4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    NEU4 antibody; LP5125Sialidase-4 antibody; EC 3.2.1.18 antibody; N-acetyl-alpha-neuraminidase 4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sialidase-4 protein (225-377AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose.
  • 基因功能參考文獻:
    1. The most potent compound tested targeted the human Neu4 isoenzyme, and was able to substantially reduce the rate of cell migration. We found that the lateral mobility of integrins was reduced by treatment of cells with Neu3, suggesting that Neu3 enzyme activity resulted in changes to integrin-co-receptor or integrin-cytoskeleton interactions PMID: 27344026
    2. The silencing or chemical inhibition of NEU4 changes the entire glycosylation pattern of proteins and lipids, making it more similar to that of differentiated GBM cells and drastically reduces GSCs survival. PMID: 25144716
    3. The results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt. PMID: 24030392
    4. Overexpression of NEU4 is associated with neuroblastoma. PMID: 22287118
    5. NEU4 is involved in regulation of neuronal function by polySia degradation in mammals. PMID: 22393058
    6. NEU4 plays an important role in control of sialyl Lewis antigen expression and its impairment in colon cancer PMID: 21521691
    7. The NEU4 long form localizes in mitochondria, while the short form is also associated with the endoplasmic reticulum. PMID: 19797320
    8. The NEU4 gene, identified by searching sequence databases for entries showing homologies to the human cytosolic sialidase NEU2, maps in 2q37 and encodes a 484-residue protein. PMID: 14962670
    9. Neu4 is a novel human lysosomal lumen sialidase PMID: 15213228
    10. Data show that the differentiation of monocytes into macrophages is associated with regulation of the expression of at least three distinct cellular sialidases, Neu1, 3, and 4, with specific up-regulation of the enzyme activity of only Neu1. PMID: 15885103
    11. related to malignancy and may be potential targets for cancer diagnosis and therapy PMID: 18651674

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cell projection, neuron projection.; [Isoform 2]: Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.
  • 蛋白家族:
    Glycosyl hydrolase 33 family
  • 組織特異性:
    [Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon.; [Isoform 2]: Highly expressed in brain and at lower levels in kidney and liver.
  • 數據庫鏈接:

    HGNC: 21328

    OMIM: 608527

    KEGG: hsa:129807

    STRING: 9606.ENSP00000320318

    UniGene: Hs.551747



主站蜘蛛池模板: 饥渴少妇av无码影片| 国产亚洲精品电影网站在线观看| 亚洲加勒比少妇无码av| 欲色欲色天天天www| 国产亚洲精品自在久久vr| 日本乱码伦午夜福利在线| 粉色午夜视频| 日产中文字幕在线观看| 性欧美老人牲交xxxxx视频| 国产在线观看无码的免费网站| 亚洲欧美日韩中字视频三区| 精品国产三级a在线观看网站| 无码中文字幕av免费放dvd| 在线成人一区二区| 日本高清在线一区二区三区 | 最新国产乱人伦偷精品免费网站| 国产二级一片内射视频播放| 夜夜精品无码一区二区三区| 久久www成人片免费看| 国产人成视频在线观看| 无码av免费一区二区三区| 欧美熟妇另类久久久久久多毛| 久久精品熟女亚州av麻豆| 国产农村毛卡片| 国产农村妇女高潮大叫| 99久久久无码国产精品不卡| 国产精品无码无在线观看| 国产精品激情欧美可乐视频 | 国产mv在线天堂mv免费观看| 麻豆日产精品卡2卡3卡4卡5卡| 久久天天躁狠狠躁夜夜2019| ā片在线观看免费观看| 性欧美老人牲交xxxxx视频| 久久精品国产亚洲欧美| 大尺度无遮挡激烈床震网站| 亚洲天堂男人影院| 国产又爽又黄无码无遮挡在线观看| 久久国产福利一区二区| 久久综合九色综合欧洲98| 亚洲熟女少妇一区二区| 青青国产线免观|