在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NEO1 Antibody, FITC conjugated

  • 中文名稱:
    NEO1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA852917LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NEO1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NEO1
  • 別名:
    Immunoglobulin superfamily DCC subclass member 2 antibody; NEO1 antibody; NEO1_HUMAN antibody; Neogenin antibody; Ngn (gene name) antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Neogenin protein (414-682AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
  • 基因功能參考文獻:
    1. Overexpression of Neo1 significantly reduced the GC cell sensitivity to cisplatin and increased the cell viability, motility and adhesion ability, and while silencing of Neo1 showed contrary results. PMID: 30064133
    2. Endogenous NTN4/NEO1 maintain neuroblastoma growth via both pro-survival and pro-migratory molecular signaling. PMID: 28038459
    3. Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin. PMID: 27716118
    4. these results suggested that GD3 recruits gamma-secretase to lipid/rafts, allowing efficient cleavage of neogenin. PMID: 27288875
    5. The hemizygous 15q deletion unmasks the recessive functional polymorphism in NEO1 which plays a pivotal role in cortical interneuron development; study provides the first evidence linking NEO1 with autism spectrum disorders in humans PMID: 26518331
    6. Neogenin influences both cadherin dynamics and junctional tension. PMID: 27029596
    7. Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways PMID: 25909166
    8. The present study demonstrates that neogenin may be a tumor suppressor in breast cancer. Neogenin may serve as a potential diagnostic marker and therapeutic target for breast cancer. PMID: 25998984
    9. These results show how repulsive guidance molecule acts as the central hub that links BMP2 and NEO1 and physically connects these fundamental signaling pathways. PMID: 25938661
    10. Neogenin expression is inversely associated with breast cancer grade. PMID: 25416629
    11. high-expression of neogenin-1 promotes gastric cancer proliferation and motility PMID: 24930499
    12. miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin. PMID: 24657544
    13. these results highlight Neogenin1 as a novel downstream effector of the Sonic Hedgehog pathway in medulloblastoma PMID: 23775842
    14. two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner. PMID: 23744777
    15. neogenin forms a ternary complex with both MT2 and HJV at the plasma membrane. The complex facilitates HJV cleavage by MT2, and release of the cleaved HJV from the cell occurs after a retrograde trafficking through the TGN/Golgi compartments. PMID: 22893705
    16. pattern of distribution suggests that a functional netrin-4-neogenin pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells PMID: 22705235
    17. the proposed role of neogenin as a tumor suppressor in gliomas PMID: 22666451
    18. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
    19. Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B. PMID: 19570425
    20. Neogenin FN5, which does not bind hemojuvelin in isolation, exhibits a highly electropositive surface, which may be involved in interactions with negatively-charged polysaccharides or phospholipids in the membrane bilayer. PMID: 20971194
    21. neogenin negatively regulates the functions of BMP and that this effect of neogenin is mediated by the activation of RhoA. PMID: 21149453
    22. results show that different isoforms of hemojuvelin may play unique physiological roles through defined interactions with distinct signaling proteins such as BMP2 and neogenin, and demonstrate that some of these interactions are defective. PMID: 18287331
    23. This study supports the hypothesis that, as in the embryo, neogenin regulates fundamental signalling pathways important for neurogenesis in the adult mouse and human forebrain. PMID: 20575069
    24. neogenin and restin have roles in proproliferation/survival action on ovarian cancer cells PMID: 12833147
    25. neogenin may play a role in mammary carcinogenesis as well as morphogenesis PMID: 16324219
    26. HJV-induced BMP signaling and hepcidin expression are not altered by neogenin overexpression or by inhibition of endogenous neogenin expr PMID: 18326817
    27. the neogenin intracellular domain regulates gene transcription via nuclear translocation PMID: 18391016
    28. neogenin-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface PMID: 18445598
    29. Results show that the serine/threonine kinase death-associated protein kinase (DAPK) is involved in the signal transduction of neogenin. PMID: 18583991
    30. Results support that hepatic neogenin possesses two functions, mediation of cellular HJV release, and stimulation of HJV-enhanced hepcidin expression. PMID: 19564337

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Immunoglobulin superfamily, DCC family
  • 組織特異性:
    Widely expressed and also in cancer cell lines.
  • 數據庫鏈接:

    HGNC: 7754

    OMIM: 601907

    KEGG: hsa:4756

    STRING: 9606.ENSP00000261908

    UniGene: Hs.388613



主站蜘蛛池模板: 亚洲欧美日韩久久精品| 无码人妻aⅴ一区二区三区69岛| 国产下药迷倒白嫩美女网站| 成人奭片免费观看| 无码人妻一区二区三区免费手机 | 亚洲伊人丝袜精品久久| 动漫成人无码精品一区二区三区| 亚洲色大成网站www永久在线观看| 无人区乱码区1卡2卡三卡网站| 成人h动漫精品一区二区无码 | 欧美精品1卡二卡三卡四卡 | 国产精品99精品久久免费| 少妇做爰免费视频网站| 久草热8精品视频在线观看| 牲交a欧美牲交aⅴ免费一| 色 综合 欧美 亚洲 国产| 熟女体下毛毛黑森林| 精品无码人妻一区二区三区品 | 99久久久精品免费观看国产| 亚洲国产精品一区二区久久hs| 伊人久久大香线蕉av网站| 激情国产av做激情国产爱| 中文字幕被公侵犯的漂亮人妻| 亚洲精品一区二区三区不卡| 性色av无码中文av有码vr| 美女裸免费观看网站| 国产成人精品三级麻豆| 无码国产69精品久久久久同性| 国产无遮挡又爽又黄大胸免费| 亚洲精品久久久久中文字幕m男| 国产精品久久一区二区三区| 天堂中文8资源在线8| 久久婷婷五月综合色欧美蜜芽 | 日韩精品无码免费专区网站| 亚洲精品久久久久午夜aⅴ| 国产成人一区二区三区| 精品无码人妻一区二区三区品| 国产精品美女久久久久久福利| 一本加勒比hezyo无码专区| 人妻丰满av无码久久不卡| 欧美成人免费全部观看国产|