在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NEIL3 Antibody

  • 中文名稱:
    NEIL3兔多克隆抗體
  • 貨號:
    CSB-PA015695GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    123 antibody; AI449477 antibody; BC034753 antibody; C85903 antibody; DNA glycosylase FPG2 antibody; DNA glycosylase hFPG2 antibody; DNA glycosylase/AP lyase Neil3 antibody; EC 3.2.2.- antibody; EC 4.2.99.18 antibody; Endonuclease 8-like 3 antibody; Endonuclease VIII-like 3 antibody; FGP2 antibody; FLJ10858 antibody; FPG2 antibody; hFPG2 antibody; hNEI3 antibody; MGC27861 antibody; MGC36916 antibody; Nei endonuclease VIII-like 3 (E. coli) antibody; nei endonuclease VIII-like 3 antibody; Nei like 3 (E. coli) antibody; Nei-like protein 3 antibody; NEI3 antibody; NEIL3 antibody; NEIL3_HUMAN antibody; OTTHUMP00000218810 antibody; RGD1310562 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Human NEIL3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases. In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues.
  • 基因功能參考文獻:
    1. This study identifies the NEIL3 promoter possessing a G-rich element that can adopt a G4 fold, and when 8-oxo-7,8-dihydroguanine is incorporated, the sequence can lock into a more stable G4 fold via recruitment of the fifth track of Gs. PMID: 29718661
    2. Results suggest a novel role for the DNA glycosylase Neil3 in atherogenesis in balancing lipid metabolism and macrophage function, potentially independently of genome-wide canonical base excision repair of oxidative DNA damage. PMID: 27328939
    3. NEIL3 protects genome stability through targeted repair of oxidative damage in telomeres during S/G2 phase. PMID: 28854357
    4. NEIL3-dependent modulation of DNA methylation regulates cardiac fibroblast proliferation and thereby affects extracellular matrix modulation after myocardial infarction. PMID: 28052262
    5. Data indicate that DNA glycosylases MYH, UNG2, MPG, NTH1, NEIL1, 2 and 3 on nascent DNA. PMID: 28575236
    6. These findings demonstrate that deficiency in NEIL3 is associated with increased lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity. PMID: 27760045
    7. SNPs in NEIL3 are associated with impulsivity in Native American sample. PMID: 27167163
    8. Single nucleotide polymorphism (SNP) rs142310826 near the NEIL3 gene showed a genome-wide significant interaction with caffeine consumption .There was no gender difference for this interaction (P = 0.64 for heterogeneity). NEIL3, a gene belonging to the base excision DNA repair pathway, encodes a DNA glycosylase that recognizes and removes lesions produced by oxidative stress. PMID: 27797824
    9. The abnormal expressions of NEIL1, NEIL2, and NEIL3 are involved in cancer through their association with the somatic mutation load. PMID: 27042257
    10. NEIL3 rs12645561 SNP TT genotype was associated with increased risk of myocardial infarction. PMID: 25703835
    11. Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM. PMID: 24005813
    12. Results show that the base excision and strand incision activities of NEIL3 exhibited a non-concerted action, indicating that NEIL3 mainly operates as a monofunctional DNA glycosylase. PMID: 23755964
    13. one role for Neil3 and NEIL1 is to repair DNA base damages in telomeres in vivo and that Neil3 and Neil1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA. PMID: 23926102
    14. Here we report the construction of bicistronic expression vectors for expressing in Escherichia coli the full-length mouse Neil3 (MmuNeil3), its glycosylase domain (MmuNeil3Delta324), as well as the glycosylase domain of human Neil3 (NEIL3Delta324). PMID: 22569481
    15. both the transcription and protein levels of hNEIL3 fluctuated during the cell cycle PMID: 22365498
    16. NEIL3 partially rescues an E. coli nth nei mutant from hydrogen peroxide sensitivity. Taken together, repair of certain base damage including base loss in ssDNA may be mediated by NEIL3. PMID: 19170771
    17. hFPG1 and hFPG2 repair 8-oxoguanine and other DNA oxidation products. (hFPG1 and hFPG2) PMID: 12433996

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    FPG family
  • 組織特異性:
    Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.
  • 數據庫鏈接:

    HGNC: 24573

    OMIM: 608934

    KEGG: hsa:55247

    STRING: 9606.ENSP00000264596

    UniGene: Hs.405467



主站蜘蛛池模板: 国产亚洲日韩欧美另类丝瓜app| 日日摸天天碰中文字幕你懂的| 久久不见久久见www免费| 第一亚洲中文久久精品无码| 亚洲精品久久久久国产| 级r片内射在线视频播放| 猫咪www免费人成网站无码| 精品一卡2卡三卡4卡乱码精品视频| 日韩精品久久久免费观看| 性视频播放免费视频| 老熟妻内射精品一区| 午夜成人影院网站18进| 国内精品久久久久av福利秒拍| 99热精品久久只有精品| 国内少妇偷人精品免费| 欧美人与动zozo在线播放| 加勒比东京热无码一区| 黄a无码片内射无码视频| 综合在线 亚洲 成人 欧美| 天堂va欧美ⅴa亚洲va| 中文字幕乱偷无码av先锋| 欧美成人aaa片一区国产精品| 成 人 黄 色 大片| 欧美大波少妇在厨房被| 国产jk精品白丝av在线观看| 老妇高潮潮喷到猛进猛出| 青乐娱精品视频一国产分类| 一本一久本久a久久精品综合| 忍不住的亲子中文字幕| 欧美阿v天堂视频在99线| 狠狠色丁香久久婷婷综合_中| 少妇爆乳无码专区| 国产69精品久久久久777| 久久久久 亚洲 无码 av 专区| av电影在线观看| 亚洲国产成人精品无码区99 | 强行糟蹋人妻hd中文| 国产免费一区二区视频| 99视频国产精品免费观看| 国产视频一区二区| 久久精品国产99国产精品导航|