在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NEIL3 Antibody

  • 中文名稱:
    NEIL3兔多克隆抗體
  • 貨號:
    CSB-PA065468
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COLO cells, HUVEC cells, HepG2 cells and HeLa cells, using NEIL3 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NEIL3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human NEIL3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases. In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues.
  • 基因功能參考文獻:
    1. This study identifies the NEIL3 promoter possessing a G-rich element that can adopt a G4 fold, and when 8-oxo-7,8-dihydroguanine is incorporated, the sequence can lock into a more stable G4 fold via recruitment of the fifth track of Gs. PMID: 29718661
    2. Results suggest a novel role for the DNA glycosylase Neil3 in atherogenesis in balancing lipid metabolism and macrophage function, potentially independently of genome-wide canonical base excision repair of oxidative DNA damage. PMID: 27328939
    3. NEIL3 protects genome stability through targeted repair of oxidative damage in telomeres during S/G2 phase. PMID: 28854357
    4. NEIL3-dependent modulation of DNA methylation regulates cardiac fibroblast proliferation and thereby affects extracellular matrix modulation after myocardial infarction. PMID: 28052262
    5. Data indicate that DNA glycosylases MYH, UNG2, MPG, NTH1, NEIL1, 2 and 3 on nascent DNA. PMID: 28575236
    6. These findings demonstrate that deficiency in NEIL3 is associated with increased lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity. PMID: 27760045
    7. SNPs in NEIL3 are associated with impulsivity in Native American sample. PMID: 27167163
    8. Single nucleotide polymorphism (SNP) rs142310826 near the NEIL3 gene showed a genome-wide significant interaction with caffeine consumption .There was no gender difference for this interaction (P = 0.64 for heterogeneity). NEIL3, a gene belonging to the base excision DNA repair pathway, encodes a DNA glycosylase that recognizes and removes lesions produced by oxidative stress. PMID: 27797824
    9. The abnormal expressions of NEIL1, NEIL2, and NEIL3 are involved in cancer through their association with the somatic mutation load. PMID: 27042257
    10. NEIL3 rs12645561 SNP TT genotype was associated with increased risk of myocardial infarction. PMID: 25703835
    11. Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM. PMID: 24005813
    12. Results show that the base excision and strand incision activities of NEIL3 exhibited a non-concerted action, indicating that NEIL3 mainly operates as a monofunctional DNA glycosylase. PMID: 23755964
    13. one role for Neil3 and NEIL1 is to repair DNA base damages in telomeres in vivo and that Neil3 and Neil1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA. PMID: 23926102
    14. Here we report the construction of bicistronic expression vectors for expressing in Escherichia coli the full-length mouse Neil3 (MmuNeil3), its glycosylase domain (MmuNeil3Delta324), as well as the glycosylase domain of human Neil3 (NEIL3Delta324). PMID: 22569481
    15. both the transcription and protein levels of hNEIL3 fluctuated during the cell cycle PMID: 22365498
    16. NEIL3 partially rescues an E. coli nth nei mutant from hydrogen peroxide sensitivity. Taken together, repair of certain base damage including base loss in ssDNA may be mediated by NEIL3. PMID: 19170771
    17. hFPG1 and hFPG2 repair 8-oxoguanine and other DNA oxidation products. (hFPG1 and hFPG2) PMID: 12433996

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    FPG family
  • 組織特異性:
    Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.
  • 數據庫鏈接:

    HGNC: 24573

    OMIM: 608934

    KEGG: hsa:55247

    STRING: 9606.ENSP00000264596

    UniGene: Hs.405467



主站蜘蛛池模板: 国产99久久久国产无需播放器| 久热这里只有精品视频6| 久久亚洲精品国产精品777777| 亚洲人禽杂交av片久久| 鲁鲁网亚洲站内射污| 四虎免费大片aⅴ入口| 99久久久无码国产精品秋霞网| 国产亚洲熟妇在线视频| 青青青国产在线观看免费| 亚洲成年看片在线观看| 久久无码字幕中文久久无码| 精品无码国产自产拍在线观看蜜| 国模国产精品嫩模大尺度视频| 永久黄网站色视频免费看| 天天天天躁天天爱天天碰2018| 少妇又紧又色又爽又刺激视频| 国产精品乱子伦xxxx裸| 男女啪啪网站大全免费 | 中文字幕网伦射乱中文| 熟妇人妻无乱码中文字幕真矢织江| 久久精品国产99久久无毒不卡 | 亚洲欧美综合精品成人导航 | 上司人妻互换hd无码| 国产jk白丝在线观看免费| 中文字幕人成乱码熟女| 久久精品国产精品亚洲下载| 又黄又湿啪啪响18禁| 久爱www成人网免费视频| 免费无码成人片| 久久亚洲精品成人无码网站夜色 | 女狠狠噜天天噜日日噜| 在线精品自偷自拍无码中文| 丰满人妻被中出中文字幕| 久久天天躁夜夜躁狠狠i女人| 无码啪啪熟妇人妻区| 亚洲综合另类小说色区一| 88久久精品无码一区二区毛片| 久久婷婷五月综合中文字幕| 欧美日韩亚洲精品瑜伽裤| 欲香欲色天天天综合和网| 变态另类先锋影音|