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  4. NEBL Antibody

NEBL Antibody

  • 中文名稱：
    NEBL兔多克隆抗體
  • 貨號：
    CSB-PA015673LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of PC-3 cells with CSB-PA015673LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NEBL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NEBL
  • 別名：
    NEBL antibody; LNEBLNebulette antibody; Actin-binding Z-disk protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Nebulette protein (438-533AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，NEBL Antibody (CSB-PA015673LA01HU)，的標(biāo)記方式是Non-conjugated。對于NEBL Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA015673LB01HU NEBL Antibody, HRP conjugated ELISA
    FITC CSB-PA015673LC01HU NEBL Antibody, FITC conjugated
    Biotin CSB-PA015673LD01HU NEBL Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion.
  • 基因功能參考文獻：
    1. Survival analysis suggested that overexpressed NEBL in patients with colorectal cancer was associated with a positive prognosis for overall survival. PMID: 29257257
    2. LASP2 may play a significant role in suppressing CRC progression and provided a novel biomarker for CRC therapy PMID: 28606091
    3. The levels of phosphorylated FAK (Tyr397 and Tyr925) were increased after overexpressing Lasp2 and were downregulated by transfecting Lasp2-siRNA. PMID: 28667800
    4. predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL common variants in the chromosome 10p13 linkage region PMID: 24563210
    5. We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2 PMID: 23985323
    6. Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin and paxillin. PMID: 23389630
    7. Report oncogenic potential of MLL-NEBL and NEBL-MLL fusion genes in acute myeloid leukemia. PMID: 23340173
    8. Different mutations in nebulette transgene trigger a pathological cascade leading to endocardial fibroelastosis and dilated cardiomyopathy in mutant embryonic mouse hearts. PMID: 20951326
    9. our data demonstrate the importance of this cardiac-specific nebulin isoform in myofibril organization and function. Our data demonstrate that nebulette plays a significant role in the structure and stability of the cardiac Z-line. PMID: 11822876
    10. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions PMID: 15004028
    11. filamin-C, a known component of striated muscle Z-lines, interacts with nebulette modules PMID: 17987659
    12. the importance of the nebulette-TPM interactions in the maintenance and stability of the thin filaments. PMID: 18823973

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  • 亞細胞定位：
    [Isoform 2]: Cytoplasm.
  • 組織特異性：
    Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16932

    OMIM: 605491

    KEGG: hsa:10529

    STRING: 9606.ENSP00000366326

    UniGene: Hs.5025



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