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NEBL Antibody, Biotin conjugated

  • 中文名稱:
    NEBL兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA015673LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NEBL Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NEBL
  • 別名:
    NEBL antibody; LNEBLNebulette antibody; Actin-binding Z-disk protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Nebulette protein (438-533AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion.
  • 基因功能參考文獻:
    1. Survival analysis suggested that overexpressed NEBL in patients with colorectal cancer was associated with a positive prognosis for overall survival. PMID: 29257257
    2. LASP2 may play a significant role in suppressing CRC progression and provided a novel biomarker for CRC therapy PMID: 28606091
    3. The levels of phosphorylated FAK (Tyr397 and Tyr925) were increased after overexpressing Lasp2 and were downregulated by transfecting Lasp2-siRNA. PMID: 28667800
    4. predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL common variants in the chromosome 10p13 linkage region PMID: 24563210
    5. We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2 PMID: 23985323
    6. Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin and paxillin. PMID: 23389630
    7. Report oncogenic potential of MLL-NEBL and NEBL-MLL fusion genes in acute myeloid leukemia. PMID: 23340173
    8. Different mutations in nebulette transgene trigger a pathological cascade leading to endocardial fibroelastosis and dilated cardiomyopathy in mutant embryonic mouse hearts. PMID: 20951326
    9. our data demonstrate the importance of this cardiac-specific nebulin isoform in myofibril organization and function. Our data demonstrate that nebulette plays a significant role in the structure and stability of the cardiac Z-line. PMID: 11822876
    10. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions PMID: 15004028
    11. filamin-C, a known component of striated muscle Z-lines, interacts with nebulette modules PMID: 17987659
    12. the importance of the nebulette-TPM interactions in the maintenance and stability of the thin filaments. PMID: 18823973

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  • 亞細胞定位:
    [Isoform 2]: Cytoplasm.
  • 組織特異性:
    Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts.
  • 數據庫鏈接:

    HGNC: 16932

    OMIM: 605491

    KEGG: hsa:10529

    STRING: 9606.ENSP00000366326

    UniGene: Hs.5025



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