在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NDUFS1 Antibody

  • 中文名稱:
    NDUFS1兔多克隆抗體
  • 貨號:
    CSB-PA015660DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: NDUFS1 antibody at 2.41 μg/ml
      Lane 1: Mouse heart tissue
      Lane 2: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 80, 81, 68, 74, 76 kDa
      Observed band size: 80 kDa
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA015660DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015660DSR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NDUFS1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CI-75kD antibody; Complex I 75Kd antibody; Complex I, mitochondrial respiratory chain, 75 kD subunit antibody; Complex I-75kD antibody; mitochondrial antibody; NADH coenzyme Q reductase antibody; NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase) antibody; NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial antibody; NADH-ubiquinone oxidoreductase 75 kDa subunit antibody; NDUFS1 antibody; NDUS1_HUMAN antibody; PRO1304 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial protein (80-290AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.
  • 基因功能參考文獻:
    1. Results show that NDUFS1 protein and mRNA levels are down-regulated in lung neoplasm and correlate with poor overall survival. PMID: 27516145
    2. High NDUFS1 expression is associated with cognitive impairment in lung cancer. PMID: 26987334
    3. Results found nominal significant associations of 2 SNPs in the NDUFS1 gene and 4 SNPs in the NDUFS2 gene with early onset schizophrenia (EOS), but none of these associations survived the Bonferroni correction. PMID: 26053550
    4. Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I. PMID: 26235939
    5. NDUFS1 may confer susceptibility to schizophrenia in male subjects, acting as a causative factor for the severity of negative symptoms in schizophrenia. PMID: 25354934
    6. The presented clinical courses of NDUFV1 and NDUFS1 mutation-based complex I deficiencies are characterized by leukoencephalopathy or early death and expand the already heterogeneous phenotypic spectrum. PMID: 25615419
    7. Some mutations in NDUFS1 cause a milder phenotype with a more benign course despite the initial decompensation phase. Homozygosity for the c.755A > G missense mutation may correlate with the milder clinical picture in the patient. PMID: 24952175
    8. The peripheral leukocyte oxidative phosphorylation enzyme activity assay was found to be a reliable method for the diagnosis of mitochondrial diseases. PMID: 21540367
    9. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    10. homozygous c.1783A>G (p.Thr595Ala) mutation in NDUFS1 in two inbred siblings with isolated complex I deficiency associated to a progressive cavitating leukoencephalopathy PMID: 21203893
    11. data suggest that gamma oscillations are especially energy demanding and require both high complex I expression and strong functional performance of mitochondria. PMID: 21183487
    12. report 3 patients with low residual complex I activity who displayed novel mutations in the NDUFS1 gene. One mutation introduces a premature stop codon, 3 mutations cause a substitution of amino acids and another mutation a deletion of one amino acid. PMID: 20382551
    13. Mutations in electron Transport Complex I is associated with Leber hereditary optic neuropathy failing to compensate for impaired oxidative phosphorylation. PMID: 19836344
    14. A patient with Leigh syndrome had a mutation in the NDUFS1 protein of Complex I of the Respiratory Chain. Identifying nuclear mutations will help us understand how molecular defects can lead to complex I deficiency. PMID: 15824269
    15. mutations in the NDUFS1 and NDUFS4 genes of complex I cause dysfunction in cellular oxidative metabolism PMID: 16478720
    16. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953

    顯示更多

    收起更多

  • 相關疾病:
    Mitochondrial complex I deficiency (MT-C1D)
  • 亞細胞定位:
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族:
    Complex I 75 kDa subunit family
  • 數據庫鏈接:

    HGNC: 7707

    OMIM: 157655

    KEGG: hsa:4719

    STRING: 9606.ENSP00000392709

    UniGene: Hs.471207



主站蜘蛛池模板: 亚洲aⅴ永久无码一区二区三区| 狠狠色综合激情丁香五月| 久久人人爽人人爽人人片| 国产乱子伦三级在线播放| 中文成人无码精品久久久动漫 | 亚洲国产一区二区三区在观看| 四虎精品国产永久在线观看| 欧美性猛交内射兽交老熟妇| 18禁美女裸体免费网站| 日本丰满妇人成熟免费中文字幕| 午夜无码一区二区三区在线| 日本免费高清线视频免费| 波多野结av衣东京热无码专区| 在线不卡日本v一区二区| 极品少妇被猛得白浆直喷白浆小说| 激情按摩系列片aaaa| 日本强好片久久久久久aaa| 韩国午夜福利片在线观看| 亚洲中文字幕在线无码一区二区 | 免费看成人aa片无码视频| 男女猛烈无遮挡免费视频app| 成年女人黄小视频| 人妻中文字幕av无码专区| 成人国产片视频在线观看| 最新在线精品国自产拍视频| 久久av无码αv高潮αv喷吹| 男女超爽视频免费播放| 国产高清不卡免费视频| 人与嘼av免费| 色av综合av综合无码网站| 永久免费观看黄网视频| 久久久久久好爽爽久久| 97久久精品人人澡人人爽| 97无码免费人妻超级碰碰夜夜| 在线视频免费无码专区| 中文天堂网www新版资源在线| 亚洲日韩av无码中文字幕美国| 又爽又黄又无遮挡的激情视频免费 | av狼友无码国产在线观看| 国产女人抽搐喷浆视频| 老熟女五十路乱子交尾中出一区|