在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NDUFS1 Antibody

  • 中文名稱:
    NDUFS1兔多克隆抗體
  • 貨號:
    CSB-PA020041
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CI-75kD antibody; Complex I 75Kd antibody; Complex I, mitochondrial respiratory chain, 75 kD subunit antibody; Complex I-75kD antibody; mitochondrial antibody; NADH coenzyme Q reductase antibody; NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase) antibody; NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial antibody; NADH-ubiquinone oxidoreductase 75 kDa subunit antibody; NDUFS1 antibody; NDUS1_HUMAN antibody; PRO1304 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human NDUFS1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.
  • 基因功能參考文獻:
    1. Results show that NDUFS1 protein and mRNA levels are down-regulated in lung neoplasm and correlate with poor overall survival. PMID: 27516145
    2. High NDUFS1 expression is associated with cognitive impairment in lung cancer. PMID: 26987334
    3. Results found nominal significant associations of 2 SNPs in the NDUFS1 gene and 4 SNPs in the NDUFS2 gene with early onset schizophrenia (EOS), but none of these associations survived the Bonferroni correction. PMID: 26053550
    4. Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I. PMID: 26235939
    5. NDUFS1 may confer susceptibility to schizophrenia in male subjects, acting as a causative factor for the severity of negative symptoms in schizophrenia. PMID: 25354934
    6. The presented clinical courses of NDUFV1 and NDUFS1 mutation-based complex I deficiencies are characterized by leukoencephalopathy or early death and expand the already heterogeneous phenotypic spectrum. PMID: 25615419
    7. Some mutations in NDUFS1 cause a milder phenotype with a more benign course despite the initial decompensation phase. Homozygosity for the c.755A > G missense mutation may correlate with the milder clinical picture in the patient. PMID: 24952175
    8. The peripheral leukocyte oxidative phosphorylation enzyme activity assay was found to be a reliable method for the diagnosis of mitochondrial diseases. PMID: 21540367
    9. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    10. homozygous c.1783A>G (p.Thr595Ala) mutation in NDUFS1 in two inbred siblings with isolated complex I deficiency associated to a progressive cavitating leukoencephalopathy PMID: 21203893
    11. data suggest that gamma oscillations are especially energy demanding and require both high complex I expression and strong functional performance of mitochondria. PMID: 21183487
    12. report 3 patients with low residual complex I activity who displayed novel mutations in the NDUFS1 gene. One mutation introduces a premature stop codon, 3 mutations cause a substitution of amino acids and another mutation a deletion of one amino acid. PMID: 20382551
    13. Mutations in electron Transport Complex I is associated with Leber hereditary optic neuropathy failing to compensate for impaired oxidative phosphorylation. PMID: 19836344
    14. A patient with Leigh syndrome had a mutation in the NDUFS1 protein of Complex I of the Respiratory Chain. Identifying nuclear mutations will help us understand how molecular defects can lead to complex I deficiency. PMID: 15824269
    15. mutations in the NDUFS1 and NDUFS4 genes of complex I cause dysfunction in cellular oxidative metabolism PMID: 16478720
    16. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953

    顯示更多

    收起更多

  • 相關疾病:
    Mitochondrial complex I deficiency (MT-C1D)
  • 亞細胞定位:
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族:
    Complex I 75 kDa subunit family
  • 數據庫鏈接:

    HGNC: 7707

    OMIM: 157655

    KEGG: hsa:4719

    STRING: 9606.ENSP00000392709

    UniGene: Hs.471207



主站蜘蛛池模板: 黑人巨大videos精品| 国产亚洲精品精品精品| 国产精品久久久久久无码| 99久久国产精品免费高潮| 综合色区国产亚洲另类 | 中国老熟女重囗味hdxx| 天躁夜夜躁狼狠躁| 久久/这里只精品热在线获取| 4480yy私人精品国产| 无码中文字幕乱在线观看| 好爽别插了无码视频| 亚洲国产精品无码久久一线| 国产亚洲精品国产福利你懂的| 日日摸日日碰夜夜爽av| 国产精品www夜色视频| 国产无夜激无码av毛片| 一区二区三区四区在线 | 欧洲| 午夜亚洲福利在线老司机| 国产精品国产免费无码专区不卡 | 欧美另类又黄又爽的a片| 欧美精品色婷婷五月综合| 我和亲妺妺乱的性视频| 精品久久一区二区乱码| 亚洲欧美午夜理论电影在线观看| 日韩人妻无码精品久久久不卡| 久久婷婷激情综合色综合俺也去| 99精品产国品一二三产区| 亚洲午夜福利在线视频| 国产精品久久久久久久久久久不卡 | 十八禁无码精品a∨在线观看| 国产欧美日韩另类精彩视频| 99久久精品无码一区二区三区| 国内精品久久久久久久影视| 最新国产精品无码| 欧美日韩亚洲国内综合网| 日韩人妻无码精品免费shipin| 韩国久久久久久级做爰片| 无遮挡边吃摸边吃奶边做| 曰韩无码av片免费播放不卡| 久久综合精品国产一区二区三区无码| 色欲综合久久躁天天躁|