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  4. NCOA5 Antibody

NCOA5 Antibody

  • 中文名稱：
    NCOA5兔多克隆抗體
  • 貨號：
    CSB-PA015544GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NCOA5
  • 別名：
    NCOA5 antibody; KIAA1637 antibody; Nuclear receptor coactivator 5 antibody; NCoA-5 antibody; Coactivator independent of AF-2 antibody; CIA antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human NCOA5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
  • 基因功能參考文獻(xiàn)：
    1. knockout of NCOA5 can suppress the epithelial - mesenchymal transition (EMT) in hepatocellular carcinoma cells. PMID: 29626478
    2. This study provides new insights and evidences that NOCA5 over-expression was significantly correlated with progression and prognosis in luminal breast cancer. However, the precise cellular mechanisms for NOCA5 in luminal breast cancer need to be further explored. PMID: 27847318
    3. NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma. PMID: 25416054
    4. suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC, partially by increasing IL-6 expression PMID: 24332041
    5. gene polymorphism confers susceptibility to psoriasis in a Southern European population PMID: 21645569

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15909

    KEGG: hsa:57727

    STRING: 9606.ENSP00000290231

    UniGene: Hs.654991



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