在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NCK2 Antibody

  • 中文名稱:
    NCK2兔多克隆抗體
  • 貨號:
    CSB-PA070023
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cytoplasmic protein NCK2 antibody; GRB4 antibody; Growth factor receptor bound protein 4 antibody; NCK adaptor protein 2 antibody; Nck-2 antibody; NCK2 antibody; NCK2_HUMAN antibody; NCKbeta antibody; Non-catalytic region of tyrosine kinase adaptor protein 2 antibody; Noncatalytic region of tyrosine kinase beta antibody; SH2/SH3 adaptor protein NCK-beta antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human Nck-2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
  • 基因功能參考文獻:
    1. This study provides evidence of a possible role of NCK2 as biomarker of ovarian cancer progression. PMID: 29218693
    2. There was no difference in the Nck2 mRNA expression between the SLE patients and the healthy subjects. PMID: 29911835
    3. Nck1 and Nck2 Interact with WTIP. Nck1/2 integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP. PMID: 27033705
    4. Data suggest that PINCH1 and Nck2 critically participate in the regulation of cellular radiosensitivity and EGFR function and downstream signaling in a cellular model of human squamous cell carcinoma. PMID: 26004008
    5. Tir-Intimin interaction recruits the Nck adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP). PMID: 25482634
    6. Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. PMID: 24287595
    7. NCK2 is involved in the susceptibility to opiates addiction. PMID: 23533358
    8. The hNck2 SH3 domain also exhibited pH dependent monomer-dimer transition. PMID: 23524290
    9. Data show that both HK2 and NCK2 are expressed in the retinal ganglion cell layer. PMID: 23349798
    10. Nck2 effectively influences human melanoma phenotype progression. PMID: 21992144
    11. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. PMID: 21949127
    12. Nck2 is an adaptor protein composed of 3N-SH3 domains followed by a unique Cterminal SH2 domain. It interacts with PINCH in integrin signal transduction, cell migratio and survival. Review. PMID: 21880263
    13. biophysical analysis of Nck2 SH3 domain PMID: 19956763
    14. Nck-2 interacts with focal adhesion kinase and modulates cell motility. Using a mutational strategy, the formation of the Nck-2-FAK complex is mediated by interactions involving multiple SH2 and SH3 domains of Nck-2. PMID: 11950595
    15. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. PMID: 12110186
    16. analysis of binding between the Tyr-phosphorylated human ephrinB2 and Nck2 SH2 domain PMID: 15764601
    17. Molecular model of the first SRC homology 3 domain of Nck2. PMID: 16604428
    18. Nck1 (Nckalpha) and Nck2 (Nckbeta and Grb4): binding specificities of both SH2 domains are essentially indistinguishable PMID: 16636066
    19. determined the NMR structures and dynamic properties of the hNck2 SH3 domains and to define their ligand binding preferences with nine proline-rich peptides derived from Wire, CAP-1, CAP-2, Prk, Wrch1, Wrch2, and Nogo PMID: 16752908
    20. Data show that Nck (isoforms 1 and 2) as a component of the CReP/PP1c holophosphatase complex contributes to maintain eIF2alpha in a hypophosphorylated state, and modulates translation and eIF2alpha signaling in response to ER stress. PMID: 16835242
    21. Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response. PMID: 17803907
    22. the adaptors Nck and ShcA influenced adherence of S. Typhimurium to non-phagocytic cells. PMID: 17906149
    23. Data show that Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the activation motif and a T-cell receptor endocytosis signal. PMID: 18555270
    24. Results point to NCK2 as a disease candidate gene and further supports the GLC1B locus as an important genomic region that is associated with the genetic predisposition to glaucoma. PMID: 18723748
    25. independent roles and mechanisms of action of Nckalpha and Nckbeta in dermal fibroblast migration, which is critical for wound healing. PMID: 19242519

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Endoplasmic reticulum.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 7665

    OMIM: 604930

    KEGG: hsa:8440

    STRING: 9606.ENSP00000233154

    UniGene: Hs.529244



主站蜘蛛池模板: 午夜无码一区二区三区在线| 无码人妻aⅴ一区二区三区69岛 | 超碰97人人做人人爱亚洲尤物| 亚洲2020天天堂在线观看| 久久精品无码一区二区www| 国产狂喷潮在线观看中文| 久久婷婷五月综合色国产| 精品国产18久久久久久| 国产猛男猛女超爽免费视频| 成人亚欧欧美激情在线观看| 天堂√在线中文最新版| 亚洲成在人线在线播放无码| 欧美午夜精品一区二区三区电影| 四虎亚洲欧美成人网站| 又大又粗又爽免费视频a片| 亚瑟av亚洲精品一区二区| 无码少妇一区二区三区| 天天做天天爱天天综合网2021| 中文无码伦av中文字幕在线| 无码毛片一区二区本码视频| 午夜福利视频| 加勒比无码人妻东京热 | 三级全黄的视频在线观看| 久久无码人妻影院| 国内精品卡一卡二卡三| 曰韩精品无码一区二区视频| 天天爽夜夜爽人人爽免费| 欧美乱妇高清无乱码在线观看| 永久免费的av片在线电影网| 午夜爱爱免费视频体验区| 亚洲精品久久久久久久蜜桃臀| 亚洲成在人线视av| 午夜美女裸体福利视频| 丰满少妇aaaaaa爰片毛片| 国产女人18毛片水真多18精品 | 国内精品久久久久影院老司机| 国产激情电影综合在线看| 97精品人人a片免费看| 中文字幕人妻熟女人妻a片| 久久不见久久见免费视频1′| 99久久久无码国产精品9|