在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Cytoplasmic protein NCK2 (NCK2)

Recombinant Human Cytoplasmic protein NCK2 (NCK2)

  • 中文名稱：
    人NCK2重組蛋白
  • 貨號：
    CSB-YP015531HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NCK2重組蛋白
  • 貨號：
    CSB-EP015531HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NCK2重組蛋白
  • 貨號：
    CSB-BP015531HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NCK2重組蛋白
  • 貨號：
    CSB-MP015531HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cytoplasmic protein NCK2; GRB4; Growth factor receptor bound protein 4; NCK adaptor protein 2; Nck-2; NCK2; NCK2_HUMAN; NCKbeta; Non-catalytic region of tyrosine kinase adaptor protein 2; Noncatalytic region of tyrosine kinase beta; SH2/SH3 adaptor protein NCK-beta
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-380
  • 氨基酸序列
    MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN SLKKGSLVKN LKDTLGLGKT RRKTSARDAS PTPSTDAEYP ANGSGADRIY DLNIPAFVKF AYVAEREDEL SLVKGSRVTV MEKCSDGWWR GSYNGQIGWF PSNYVLEEVD EAAAESPSFL SLRKGASLSN GQGSRVLHVV QTLYPFSSVT EEELNFEKGE TMEVIEKPEN DPEWWKCKNA RGQVGLVPKN YVVVLSDGPA LHPAHAPQIS YTGPSSSGRF AGREWYYGNV TRHQAECALN ERGVEGDFLI RDSESSPSDF SVSLKASGKN KHFKVQLVDN VYCIGQRRFH TMDELVEHYK KAPIFTSEHG EKLYLVRALQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
  • 基因功能參考文獻：
    1. This study provides evidence of a possible role of NCK2 as biomarker of ovarian cancer progression. PMID: 29218693
    2. There was no difference in the Nck2 mRNA expression between the SLE patients and the healthy subjects. PMID: 29911835
    3. Nck1 and Nck2 Interact with WTIP. Nck1/2 integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP. PMID: 27033705
    4. Data suggest that PINCH1 and Nck2 critically participate in the regulation of cellular radiosensitivity and EGFR function and downstream signaling in a cellular model of human squamous cell carcinoma. PMID: 26004008
    5. Tir-Intimin interaction recruits the Nck adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP). PMID: 25482634
    6. Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. PMID: 24287595
    7. NCK2 is involved in the susceptibility to opiates addiction. PMID: 23533358
    8. The hNck2 SH3 domain also exhibited pH dependent monomer-dimer transition. PMID: 23524290
    9. Data show that both HK2 and NCK2 are expressed in the retinal ganglion cell layer. PMID: 23349798
    10. Nck2 effectively influences human melanoma phenotype progression. PMID: 21992144
    11. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. PMID: 21949127
    12. Nck2 is an adaptor protein composed of 3N-SH3 domains followed by a unique Cterminal SH2 domain. It interacts with PINCH in integrin signal transduction, cell migratio and survival. Review. PMID: 21880263
    13. biophysical analysis of Nck2 SH3 domain PMID: 19956763
    14. Nck-2 interacts with focal adhesion kinase and modulates cell motility. Using a mutational strategy, the formation of the Nck-2-FAK complex is mediated by interactions involving multiple SH2 and SH3 domains of Nck-2. PMID: 11950595
    15. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. PMID: 12110186
    16. analysis of binding between the Tyr-phosphorylated human ephrinB2 and Nck2 SH2 domain PMID: 15764601
    17. Molecular model of the first SRC homology 3 domain of Nck2. PMID: 16604428
    18. Nck1 (Nckalpha) and Nck2 (Nckbeta and Grb4): binding specificities of both SH2 domains are essentially indistinguishable PMID: 16636066
    19. determined the NMR structures and dynamic properties of the hNck2 SH3 domains and to define their ligand binding preferences with nine proline-rich peptides derived from Wire, CAP-1, CAP-2, Prk, Wrch1, Wrch2, and Nogo PMID: 16752908
    20. Data show that Nck (isoforms 1 and 2) as a component of the CReP/PP1c holophosphatase complex contributes to maintain eIF2alpha in a hypophosphorylated state, and modulates translation and eIF2alpha signaling in response to ER stress. PMID: 16835242
    21. Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response. PMID: 17803907
    22. the adaptors Nck and ShcA influenced adherence of S. Typhimurium to non-phagocytic cells. PMID: 17906149
    23. Data show that Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the activation motif and a T-cell receptor endocytosis signal. PMID: 18555270
    24. Results point to NCK2 as a disease candidate gene and further supports the GLC1B locus as an important genomic region that is associated with the genetic predisposition to glaucoma. PMID: 18723748
    25. independent roles and mechanisms of action of Nckalpha and Nckbeta in dermal fibroblast migration, which is critical for wound healing. PMID: 19242519

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Endoplasmic reticulum.
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 7665

    OMIM: 604930

    KEGG: hsa:8440

    STRING: 9606.ENSP00000233154

    UniGene: Hs.529244



主站蜘蛛池模板： 国产免费午夜福利不卡片在线| 极品少妇hdxx麻豆hdxx| 精品不卡一区二区| 乱中年女人伦av一区二区| 亚洲日韩精品射精日| 日韩欧美亚洲综合久久影院ds| 国产成人精品日本亚洲语音| 东北老女人高潮大叫对白| 日本精品人妻无码77777| 风流少妇按摩来高潮| 综合在线视频精品专区| 人人澡人人妻人人爽人人蜜桃麻豆 | 亚洲欧洲久久av| 人妻聚色窝窝人体www一区| 未满小14洗澡无码视频网站| 欧美人与物videos另类xxxxx| 一本一道中文字幕无码东京热| 高清无码爆乳潮喷在线观看| 肥臀熟女一区二区三区| 国产亚洲精品久久久久久大师| 成人国产片视频在线观看| 少妇久久久久久人妻无码| 亚洲丁香婷婷久久一区二区| 黑鬼大战白妞高潮喷白浆| yy6080久久伦理一区二区| av无码一区二区二三区1区6区 | 亚洲肥老太bbw中国熟女| 最新亚洲春色av无码专区| 欧美亚洲综合成人a∨在线 | 老男人久久青草av高清| 东北老女人高潮大叫对白| 色噜噜狠狠色综合成人网| 中文字幕无码专区一va亚洲v专区在线 | 凹凸国产熟女精品视频| 97se亚洲综合自在线| mm1313亚洲国产精品无码试看| 99久久婷婷国产综合精品电影| 男男gv白嫩小受gv在线播放| 国产片免费福利片永久| 欧美一区二区三区红桃小说 | 色婷婷综合久久久久中文一区二区 |