在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NCF4 Antibody

  • 中文名稱:
    NCF4兔多克隆抗體
  • 貨號:
    CSB-PA020034
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CGD3 antibody; MGC3810 antibody; NCF 4 antibody; NCF antibody; NCF-4 antibody; Ncf4 antibody; NCF4_HUMAN antibody; Neutrophil cytosol factor 4 antibody; Neutrophil cytosolic factor 4 antibody; Neutrophil NADPH oxidase factor 4 antibody; p40-phox antibody; p40phox antibody; SH3 and PX domain-containing protein 4 antibody; SH3PXD4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from Human p40-phox around the non-phosphorylation site of T154.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
  • 基因功能參考文獻:
    1. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW} PMID: 26289093
    2. NCF4 may induce ex- pression of NADPH oxidase enzymes, such as p67phox, p47phox, p22phox and NOX2, which lead to increased ROS levels. PMID: 24378533
    3. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer. PMID: 23982929
    4. The contribution of the functionally relevant NADPH polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity. PMID: 23576480
    5. Constitutive and inducible intracellular production of reactive oxygen species (ROS) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS generation. PMID: 22984083
    6. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults. PMID: 21472827
    7. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease. PMID: 22158027
    8. cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis PMID: 21956105
    9. Results demonstrate that PBEF can prime for PMN respiratory burst activity by promoting p40 and p47 translocation to the membrane. PMID: 21518975
    10. no association between SNP rs4821544 and the presence of granulomas in Crohn's disease PMID: 21122541
    11. cytosolic localisation depends on direct interaction with F-actin PMID: 20637895
    12. All mutations and some polymorphisms identified in the NCF4 gene in the autosomal forms of chronic granulomatous disease are listed. Review. PMID: 20167518
    13. p40(phox) functions primarily to regulate Fc gamma receptor-induced NADPH oxidase activity rather than assembly, and stimulates superoxide production via a phosphatidylinositol-3-phosphate signal that increases after phagosome internalization. PMID: 18711001
    14. Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils PMID: 11903052
    15. Multiple PU.1 sites cooperate in the regulation of p40(phox) transcription during granulocytic differentiation of myeloid cells. PMID: 12036891
    16. p40phox and p47phox PX domains interact with PI-containing membranes PMID: 12556460
    17. A model is proposed in which phosphorylation of p40PHOX on threonine 154 leads to an inhibitory conformation that shifts the balance toward an inhibitory role and blocks NADPH oxidase activation. PMID: 15035643
    18. review of p40phox role in NADPH oxidase dynamics and possible non-NADPH oxidase processes in phagocytic and non-phagocytic cells PMID: 16102984
    19. This study identifies a role for p40(phox) and PI(3)P in coupling FcgammaR-mediated phagocytosis to activation of the NADPH oxidase. PMID: 16880255
    20. analysis of the dual regulatory mechanism through the PX domain of p40(phox): its interaction with the actin cytoskeleton may stabilize NADPH oxidase in resting cells, and binding of PtdIns (3)P potentiates superoxide production upon agonist stimulation PMID: 17698849
    21. In Swedish men with rheumatoid arthritis there were several single nucleotide polymorphisms identified in NCF4. PMID: 17897462
    22. This study has confirmed NCF4 and IRGM are risk factors for ileal Crohn's disease in New Zealand Caucasians. PMID: 18580884
    23. Class III PI3K Vps34 is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18-dependent activation oxidase activation in response to S aureus and E coli PMID: 18755982
    24. regulates activity of NADPH oxidase which generates superoxide production in neutrophils. (review) PMID: 18807499
    25. p40(phox) binding to PtdIns(3)P is essential for phagocytosis-induced oxidant production in human neutrophils and its absence can be associated with disease. PMID: 19692703

    顯示更多

    收起更多

  • 相關疾病:
    Granulomatous disease, chronic, cytochrome-b-positive 3, autosomal recessive (CGD3)
  • 亞細胞定位:
    Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein.
  • 組織特異性:
    Expression is restricted to hematopoietic cells.
  • 數據庫鏈接:

    HGNC: 7662

    OMIM: 601488

    KEGG: hsa:4689

    STRING: 9606.ENSP00000380334

    UniGene: Hs.474781



主站蜘蛛池模板: 一本大道大臿蕉视频无码| 在线精品视频一区二区| 国产在线第一区二区三区| 国产精品玩偶在线观看| 久久人妻av一区二区软件| 日韩人妻无码精品免费shipin| 亚洲国产精品日本无码网站| 大帝a∨无码视频在线播放| 国产成人精品三级麻豆| 亚洲精品久久久久久动漫器材一区| 在线 亚洲 国产 欧美| 伊人精品成人久久综合97| 国产午夜亚洲精品国产成人小说| 精品一区二区三区东京热| 国产精品亚洲二区在线播放| 伊人久久大香线蕉av五月天| 国产熟妇久久777777| 欧美三级欧美成人高清| 日韩免费无码人妻波多野| 又嫩又硬又黄又爽的视频| 色欲色香天天天综合无码www| 久久精品人人槡人妻人| 国产亚洲精品福利视频| 中字乱码视频| 豆国产96在线 | 亚洲| 成人影院yy111111在线| 亚洲综合久久成人a片| 国产精品高清一区二区三区| 精品精品国产男人的天堂| 亚洲欧美国产国产一区二区三区| 中文字幕乱偷无码av先锋| 精品久久久久久无码人妻| 久久/这里只精品99re66 | 在线毛片片免费观看| 成人无码视频免费播放| 色老板精品视频在线观看| 国产极品精品自在线| 午夜人性色福利无码视频在线观看| 国产又大又硬又粗| 最近中文2019字幕第二页| 4hu四虎永久在线影院|