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  4. NCF4 Antibody

NCF4 Antibody

  • 中文名稱：
    NCF4兔多克隆抗體
  • 貨號：
    CSB-PA617999LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA617999LA01HU diluted at 1:500 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of MCF-7 cells with CSB-PA617999LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NCF4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CGD3 antibody; MGC3810 antibody; NCF 4 antibody; NCF antibody; NCF-4 antibody; Ncf4 antibody; NCF4_HUMAN antibody; Neutrophil cytosol factor 4 antibody; Neutrophil cytosolic factor 4 antibody; Neutrophil NADPH oxidase factor 4 antibody; p40-phox antibody; p40phox antibody; SH3 and PX domain-containing protein 4 antibody; SH3PXD4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Neutrophil cytosol factor 4 protein (136-239AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NCF4 Antibody (CSB-PA617999LA01HU)，的標記方式是Non-conjugated。對于NCF4 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA617999LB01HU NCF4 Antibody, HRP conjugated ELISA
    FITC CSB-PA617999LC01HU NCF4 Antibody, FITC conjugated
    Biotin CSB-PA617999LD01HU NCF4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
  • 基因功能參考文獻：
    1. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW} PMID: 26289093
    2. NCF4 may induce ex- pression of NADPH oxidase enzymes, such as p67phox, p47phox, p22phox and NOX2, which lead to increased ROS levels. PMID: 24378533
    3. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer. PMID: 23982929
    4. The contribution of the functionally relevant NADPH polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity. PMID: 23576480
    5. Constitutive and inducible intracellular production of reactive oxygen species (ROS) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS generation. PMID: 22984083
    6. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults. PMID: 21472827
    7. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease. PMID: 22158027
    8. cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis PMID: 21956105
    9. Results demonstrate that PBEF can prime for PMN respiratory burst activity by promoting p40 and p47 translocation to the membrane. PMID: 21518975
    10. no association between SNP rs4821544 and the presence of granulomas in Crohn's disease PMID: 21122541
    11. cytosolic localisation depends on direct interaction with F-actin PMID: 20637895
    12. All mutations and some polymorphisms identified in the NCF4 gene in the autosomal forms of chronic granulomatous disease are listed. Review. PMID: 20167518
    13. p40(phox) functions primarily to regulate Fc gamma receptor-induced NADPH oxidase activity rather than assembly, and stimulates superoxide production via a phosphatidylinositol-3-phosphate signal that increases after phagosome internalization. PMID: 18711001
    14. Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils PMID: 11903052
    15. Multiple PU.1 sites cooperate in the regulation of p40(phox) transcription during granulocytic differentiation of myeloid cells. PMID: 12036891
    16. p40phox and p47phox PX domains interact with PI-containing membranes PMID: 12556460
    17. A model is proposed in which phosphorylation of p40PHOX on threonine 154 leads to an inhibitory conformation that shifts the balance toward an inhibitory role and blocks NADPH oxidase activation. PMID: 15035643
    18. review of p40phox role in NADPH oxidase dynamics and possible non-NADPH oxidase processes in phagocytic and non-phagocytic cells PMID: 16102984
    19. This study identifies a role for p40(phox) and PI(3)P in coupling FcgammaR-mediated phagocytosis to activation of the NADPH oxidase. PMID: 16880255
    20. analysis of the dual regulatory mechanism through the PX domain of p40(phox): its interaction with the actin cytoskeleton may stabilize NADPH oxidase in resting cells, and binding of PtdIns (3)P potentiates superoxide production upon agonist stimulation PMID: 17698849
    21. In Swedish men with rheumatoid arthritis there were several single nucleotide polymorphisms identified in NCF4. PMID: 17897462
    22. This study has confirmed NCF4 and IRGM are risk factors for ileal Crohn's disease in New Zealand Caucasians. PMID: 18580884
    23. Class III PI3K Vps34 is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18-dependent activation oxidase activation in response to S aureus and E coli PMID: 18755982
    24. regulates activity of NADPH oxidase which generates superoxide production in neutrophils. (review) PMID: 18807499
    25. p40(phox) binding to PtdIns(3)P is essential for phagocytosis-induced oxidant production in human neutrophils and its absence can be associated with disease. PMID: 19692703

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  • 相關疾病：
    Granulomatous disease, chronic, cytochrome-b-positive 3, autosomal recessive (CGD3)
  • 亞細胞定位：
    Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein.
  • 組織特異性：
    Expression is restricted to hematopoietic cells.
  • 數據庫鏈接：

    HGNC: 7662

    OMIM: 601488

    KEGG: hsa:4689

    STRING: 9606.ENSP00000380334

    UniGene: Hs.474781



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