在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NCBP1 Antibody

NCBP1 Antibody

  • 中文名稱：
    NCBP1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA015520GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NCBP1
  • 別名：
    80 kDa nuclear cap-binding protein antibody; CBP80 antibody; MGC2087 antibody; NCBP 80 kDa subunit antibody; NCBP antibody; ncbp1 antibody; NCBP1_HUMAN antibody; nuclear cap binding protein subunit 1 antibody; nuclear cap binding protein subunit 1, 80kDa antibody; Nuclear cap-binding protein subunit 1 antibody; Sto1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CBP80
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability.
  • 基因功能參考文獻(xiàn)：
    1. Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis. PMID: 26382858
    2. down-regulation of CTIF using a small interfering RNA causes a redistribution of CBP80 from polysome fractions to subpolysome fractions, without significant consequence to eIF4E distribution PMID: 22493286
    3. Cellular processes by which CBP80-CBP20 -bound messenger ribonucleoproteins (mRNPs) are remodeled to eIF4E-bound mRNPs, are overviewed. PMID: 21447822
    4. Viral mRNA associates with the influenza virus A NS1 and the cellular NCBP1 of the nuclear cap-binding complex. PMID: 21402597
    5. UPF1 binds PTC-containing mRNA more efficiently than the corresponding PTC-free mRNA in a way that is promoted by the UPF1-CBP80 interaction. PMID: 20691628
    6. crystal structure at 2.1 A resolution of CBP20 and CBP80 bound to an m(7)GpppG cap analogue PMID: 12374755
    7. Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. PMID: 12434151
    8. The organization of the CBP80-CBP20 complex suggests how the activity of eIF4G in translation initiation could be regulated through a dynamic network of overlapping intra- and intermolecular interactions. PMID: 16156639
    9. During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 and promotes the interaction of Upf1 with Upf2 but not with Stau1. PMID: 16186820
    10. Association of CBC with PARN might have importance in the regulated recruitment of PARN to the nonsense-mediated decay pathway during the pioneer round of translation. PMID: 16317009
    11. We show that NELF interacts with the nuclear cap binding complex (CBC), a heterodimeric, multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3' end processing of histone mRNAs PMID: 17499042
    12. The authors could distinguish two tyrosines, Y43 and Y20, in stabilization of the cap inside the cap-binding complex binding pocket. PMID: 19026660
    13. a new MIF4G domain-containing protein, CTIF (CBP80/20-dependent translation initiation factor) that interacts directly with CBP80 and is part of the CBP80/20-dependent translation initiation complex PMID: 19648179
    14. resolution X-ray structure for a cap-binding complex (CBC)-importin-alpha complex that provides a detailed picture for how importin-alpha binds to the CBP80 subunit of the CBC. PMID: 19668212

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    NCBP1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 7658

    OMIM: 600469

    KEGG: hsa:4686

    STRING: 9606.ENSP00000364289

    UniGene: Hs.595669



主站蜘蛛池模板： 极品嫩模高潮叫床| 97伦伦午夜电影理伦片| 亚洲精品成人无限看| 火箭视频在线观看精品| 欧美孕妇xxxx做受欧美88| 亚洲大码熟女在线| 免费久久99精品国产自在现线| 国产aⅴ激情无码久久久无码| 97久久婷婷五月综合色d啪蜜芽 | 无码色av一二区在线播放| 午夜精品久久久久久| 日日碰狠狠躁久久躁96avv| 日本妇人成熟免费中文字幕| 国产一区二区丝袜高跟鞋| 性色做爰片在线观看ww| 狠狠人妻久久久久久综合| 国产白丝精品爽爽久久久久久蜜臀| 久久精品日韩av无码| 国产精品久久久影视青草| 国产jjzzjjzz视频全部免费| 中文字字幕乱码视频高清| 一个添下面两个吃奶把腿扒开 | 欧美无遮挡很黄裸交视频| 人人妻人人澡人人爽人人精品av| 女同亚洲一区二区无线码| 国产女人叫床高潮大片| 亚洲人成电影网站色www| 狠狠色丁香婷婷久久综合| 亚洲欧美人高清精品a∨| 日韩人妻无码免费视频一区二区三区 | 18禁无遮挡无码网站免费| 亚洲国产精品无码中文字| 色噜噜狠狠狠狠色综合久| 成人精品视频一区二区三区| 亚洲乱码卡一卡二卡| 丰满岳乱妇久久久| 狠狠躁夜夜躁人人爽天天天天97| 好男人日本社区www| 亚洲色成人影院在线观看| 成人区人妻精品一熟女| 国产精品点击进入在线影院高清|