在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NCBP1 Antibody

NCBP1 Antibody

  • 中文名稱：
    NCBP1兔多克隆抗體
  • 貨號：
    CSB-PA001373
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of LOVO cells using CBP80 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NCBP1
  • 別名：
    80 kDa nuclear cap-binding protein antibody; CBP80 antibody; MGC2087 antibody; NCBP 80 kDa subunit antibody; NCBP antibody; ncbp1 antibody; NCBP1_HUMAN antibody; nuclear cap binding protein subunit 1 antibody; nuclear cap binding protein subunit 1, 80kDa antibody; Nuclear cap-binding protein subunit 1 antibody; Sto1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human CBP80.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability.
  • 基因功能參考文獻(xiàn)：
    1. Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis. PMID: 26382858
    2. down-regulation of CTIF using a small interfering RNA causes a redistribution of CBP80 from polysome fractions to subpolysome fractions, without significant consequence to eIF4E distribution PMID: 22493286
    3. Cellular processes by which CBP80-CBP20 -bound messenger ribonucleoproteins (mRNPs) are remodeled to eIF4E-bound mRNPs, are overviewed. PMID: 21447822
    4. Viral mRNA associates with the influenza virus A NS1 and the cellular NCBP1 of the nuclear cap-binding complex. PMID: 21402597
    5. UPF1 binds PTC-containing mRNA more efficiently than the corresponding PTC-free mRNA in a way that is promoted by the UPF1-CBP80 interaction. PMID: 20691628
    6. crystal structure at 2.1 A resolution of CBP20 and CBP80 bound to an m(7)GpppG cap analogue PMID: 12374755
    7. Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. PMID: 12434151
    8. The organization of the CBP80-CBP20 complex suggests how the activity of eIF4G in translation initiation could be regulated through a dynamic network of overlapping intra- and intermolecular interactions. PMID: 16156639
    9. During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 and promotes the interaction of Upf1 with Upf2 but not with Stau1. PMID: 16186820
    10. Association of CBC with PARN might have importance in the regulated recruitment of PARN to the nonsense-mediated decay pathway during the pioneer round of translation. PMID: 16317009
    11. We show that NELF interacts with the nuclear cap binding complex (CBC), a heterodimeric, multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3' end processing of histone mRNAs PMID: 17499042
    12. The authors could distinguish two tyrosines, Y43 and Y20, in stabilization of the cap inside the cap-binding complex binding pocket. PMID: 19026660
    13. a new MIF4G domain-containing protein, CTIF (CBP80/20-dependent translation initiation factor) that interacts directly with CBP80 and is part of the CBP80/20-dependent translation initiation complex PMID: 19648179
    14. resolution X-ray structure for a cap-binding complex (CBC)-importin-alpha complex that provides a detailed picture for how importin-alpha binds to the CBP80 subunit of the CBC. PMID: 19668212

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    NCBP1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7658

    OMIM: 600469

    KEGG: hsa:4686

    STRING: 9606.ENSP00000364289

    UniGene: Hs.595669



主站蜘蛛池模板： 四虎永久在线精品免费一区二区| 中文字幕色av一区二区三区| 丰满人妻被中出中文字幕| 99精品一区二区三区无码吞精| 国产男生午夜福利免费网站| 孕妇怀孕高潮潮喷视频孕妇| 国产成人久久久精品二区三区 | 成人免费看片又大又黄| 日韩免费特黄一二三区| 国产精成人品| 伊人婷婷色香五月综合缴缴情| 天天狠天天透天干天天| 国产美女视频免费观看网址| 精品国产午夜福利精品推荐| 中文字幕人成无码人妻综合社区| 看成年女人午夜毛片免费| 成人精品动漫一区二区| 日本日本乱码伦专区| 午夜亚洲福利在线老司机| 国产成人精品综合在线观看 | 人妻少妇av中文字幕乱码| 欧美人妻aⅴ中文字幕| 中文字幕精品久久久久人妻红杏ⅰ| 丰满日韩放荡少妇无码视频 | 欧美老熟妇videos极品另类| 性一交一乱一色一视频| 国产丝袜肉丝视频在线| 国产av天堂亚洲国产av天堂| 精品无人区无码乱码毛片国产| 国产成人综合欧美精品久久| 国产精品无打码在线播放| 92午夜福利少妇系列| 曰韩无码二三区中文字幕| 亚洲性无码av在线欣赏网| 国产无遮挡又黄又爽在线视频| 2022国产日产欧产精品| 无码国产69精品久久久孕妇| 国产成人无码免费视频在线| 欧美特级婬片毛多的少妇| 国产免费踩踏调教视频| 日本丰满熟妇videossex8k |