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  4. NAAA Antibody

NAAA Antibody

  • 中文名稱：
    NAAA兔多克隆抗體
  • 貨號：
    CSB-PA22919A0Rb
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA22919A0Rb diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NAAA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NAAA
  • 別名：
    Acid ceramidase like protein antibody; Acid ceramidase-like protein antibody; ASAH like protein antibody; ASAH-like protein antibody; N acylethanolamine acid amidase antibody; N acylethanolamine hydrolyzing acid amidase antibody; N acylsphingosine amidohydrolase (acid ceramidase) like antibody; N acylsphingosine amidohydrolase like antibody; N acylsphingosine amidohydrolase like protein antibody; N-acylethanolamine-hydrolyzing acid amidase subunit beta antibody; N-acylsphingosine amidohydrolase-like antibody; Naaa antibody; NAAA_HUMAN antibody; PLT antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human N-acylethanolamine-hydrolyzing acid amidase protein (29-199AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NAAA Antibody (CSB-PA22919A0Rb)，的標記方式是Non-conjugated。對于NAAA Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA22919B0Rb NAAA Antibody, HRP conjugated ELISA
    FITC CSB-PA22919C0Rb NAAA Antibody, FITC conjugated
    Biotin CSB-PA22919D0Rb NAAA Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.
  • 基因功能參考文獻：
    1. Variants a1 and a2 encoded the same full-length NAAA protein. PMID: 27693242
    2. The results suggest that N-acylethanolamine acid amidase and protein tyrosine kinase 7 may be used as potential tissue biomarkers to avoid overtreatment of non-aggressive prostate cancer PMID: 24741114
    3. MALDI-TOF MS analysis of the human NAAA zymogen (47.7 kDa) treated with peptide-N-glycosidase F (PNGase F) identified 4 glycosylation sites, and acid cleavage of the zymogen into alpha- and beta-subunits (14.6 and 33.3 kDa) activated the enzyme. PMID: 22040171
    4. The level and activity of acid ceramidase in Alzheimer disease (AD) brain may play a role in controlling neuronal apoptosis and may mediate signalling pathways involved in the molecular mechanism of AD. PMID: 15610181
    5. Asn-37, Asn-107, Asn-309, and Asn-333 are actual N-glycosylation sites. The glycosylation appeared to play an important role in stabilizing the enzyme protein. PMID: 17980170
    6. we describe the overexpression and processing of recombinant human acid ceramidase in insect cells, its purification and characterization PMID: 18020949
    7. These results showed that both N-acylethanolamine-hydrolysing acid amidase and fatty acid amide hydrolase are functionally active in human prostate cancer cells. PMID: 18806270

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  • 亞細胞定位：
    Lysosome. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Acid ceramidase family
  • 組織特異性：
    Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.
  • 數據庫鏈接：

    HGNC: 736

    OMIM: 607469

    KEGG: hsa:27163

    STRING: 9606.ENSP00000286733

    UniGene: Hs.437365



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