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  4. NAA60 Antibody

NAA60 Antibody

  • 中文名稱：
    NAA60兔多克隆抗體
  • 貨號：
    CSB-PA875691LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA875691LA01HU diluted at 1:900 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NAA60 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NAA60
  • 別名：
    FLJ11693 antibody; FLJ14154 antibody; HAT4 antibody; Histone acetyltransferase type B protein 4 antibody; N acetyltransferase 15 (GCN5 related, putative) antibody; N alpha acetyltransferase 60 antibody; N(alpha) acetyltransferase 60, NatF catalytic subunit antibody; N-acetyltransferase 15 antibody; N-alpha-acetyltransferase 60 antibody; naa60 antibody; NAA60_HUMAN antibody; NAT15 antibody; NatF catalytic subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human N-alpha-acetyltransferase 60 protein (1-94AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NAA60 Antibody (CSB-PA875691LA01HU)，的標記方式是Non-conjugated。對于NAA60 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA875691LB01HU NAA60 Antibody, HRP conjugated ELISA
    FITC CSB-PA875691LC01HU NAA60 Antibody, FITC conjugated
    Biotin CSB-PA875691LD01HU NAA60 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences.
  • 基因功能參考文獻：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that NAA60 (NAT15) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. The hNaa60 protein contains an amphipathic helix following its GNAT domain that may contribute to Golgi localization of hNaa60, and the beta7-beta8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures. PMID: 27550639
    3. analysis of the mode of cytosolic Naa60 anchoring to the Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-translational N-terminal acetylation of many transmembrane proteins PMID: 28196861
    4. Knockdown of the N-terminal acetyltransferase Naa60 compromises Golgi ribbon integrity. PMID: 26164078
    5. The first crystal structure of the N-terminal acetyltransferase Naa60 reveals two elongated loops important for substrate-specific binding not found in other NAT structures. PMID: 27320834
    6. Naa60 is necessary for maintenance of the Golgi ribbon through its Nt-acetylation of substrate protein(s) that is/are involved in Golgi ribbon structural and/or functional organization. PMID: 25732826
    7. Naa60 is an N-terminal acetyltransferase defined as NatF. Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and other Met-starting N-termini. In Drosophila cells, NAA60 knockdown induced chromosomal segregation defects. PMID: 21750686
    8. HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms [HAT4] PMID: 21981917

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  • 亞細胞定位：
    Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Acetyltransferase family, NAA60 subfamily
  • 數據庫鏈接：

    HGNC: 25875

    OMIM: 614246

    KEGG: hsa:79903

    STRING: 9606.ENSP00000385903

    UniGene: Hs.513296



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