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NAA60 Antibody, Biotin conjugated

  • 中文名稱:
    NAA60兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA875691LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NAA60 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NAA60
  • 別名:
    FLJ11693 antibody; FLJ14154 antibody; HAT4 antibody; Histone acetyltransferase type B protein 4 antibody; N acetyltransferase 15 (GCN5 related, putative) antibody; N alpha acetyltransferase 60 antibody; N(alpha) acetyltransferase 60, NatF catalytic subunit antibody; N-acetyltransferase 15 antibody; N-alpha-acetyltransferase 60 antibody; naa60 antibody; NAA60_HUMAN antibody; NAT15 antibody; NatF catalytic subunit antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human N-alpha-acetyltransferase 60 protein (1-94AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences.
  • 基因功能參考文獻:
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that NAA60 (NAT15) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. The hNaa60 protein contains an amphipathic helix following its GNAT domain that may contribute to Golgi localization of hNaa60, and the beta7-beta8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures. PMID: 27550639
    3. analysis of the mode of cytosolic Naa60 anchoring to the Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-translational N-terminal acetylation of many transmembrane proteins PMID: 28196861
    4. Knockdown of the N-terminal acetyltransferase Naa60 compromises Golgi ribbon integrity. PMID: 26164078
    5. The first crystal structure of the N-terminal acetyltransferase Naa60 reveals two elongated loops important for substrate-specific binding not found in other NAT structures. PMID: 27320834
    6. Naa60 is necessary for maintenance of the Golgi ribbon through its Nt-acetylation of substrate protein(s) that is/are involved in Golgi ribbon structural and/or functional organization. PMID: 25732826
    7. Naa60 is an N-terminal acetyltransferase defined as NatF. Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and other Met-starting N-termini. In Drosophila cells, NAA60 knockdown induced chromosomal segregation defects. PMID: 21750686
    8. HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms [HAT4] PMID: 21981917

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  • 亞細胞定位:
    Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    Acetyltransferase family, NAA60 subfamily
  • 數據庫鏈接:

    HGNC: 25875

    OMIM: 614246

    KEGG: hsa:79903

    STRING: 9606.ENSP00000385903

    UniGene: Hs.513296



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