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  4. NAA15 Antibody, Biotin conjugated

NAA15 Antibody, Biotin conjugated

  • 中文名稱：
    NAA15兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA863143LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NAA15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NAA15
  • 別名：
    5730450D16Rik antibody; 6330400I15 antibody; ASTBDN antibody; GA19 antibody; Gastric cancer antigen Ga19 antibody; MGC29428 antibody; mNAT1 antibody; N alpha acetyltransferase 15, NatA auxiliary subunit antibody; N terminal acetyltransferase antibody; N(alpha) acetyltransferase 15, NatA auxiliary subunit antibody; N-alpha-acetyltransferase 15 antibody; N-terminal acetyltransferase antibody; Naa15 antibody; NAA15_HUMAN antibody; NatA auxiliary subunit antibody; NATH antibody; NMDA receptor regulated 1 antibody; NMDA receptor regulated protein 1 antibody; NMDA receptor-regulated protein 1 antibody; Protein tubedown 1 antibody; Protein tubedown-1 antibody; Tbdn 1 antibody; Tbdn100 antibody; Transcriptional coactivator tubedown 100 antibody; tubedown-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human N-alpha-acetyltransferase 15, NatA auxiliary subunit protein (742-865AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.
  • 基因功能參考文獻：
    1. individuals with copy-number variant (CNV) deletions involving NAA15 and surrounding genes can present with mild intellectual disability, mild dysmorphic features, motor delays, and decreased growth. PMID: 29656860
    2. In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
    3. Authors highlight NAA15 as a novel candidate ID gene based on the vital role of NAA15 in the generation and differentiation of neurons in neonatal brain. PMID: 28990276
    4. Human Naa15 (NATH) and Naa10 (ARD1) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH) and Naa10 (ARD1) are cleaved during apoptosis resulting in decreased acetyltransferase activity PMID: 15496142
    5. Development of the first N-terminal acetyltransferase (NAT) inhibitors, including inhibitors to the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH). PMID: 23557624
    6. Protein N-terminal acetyltransferases (NATs), including the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH), act as N-terminal propionyltransferases. PMID: 23043182
    7. Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation. PMID: 20154145
    8. NATH, a novel gene overexpressed in papillary thyroid carcinomas. PMID: 12140756
    9. description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein PMID: 15496142
    10. levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures PMID: 16279846
    11. Loss of retinal endothelial Tbdn-1 expression may be a contributing factor in retinal blood vessel proliferation in retinopathy of prematurity. PMID: 16518308
    12. Essential role in cell survival through protein N-alpha-acetylation. PMID: 16518407
    13. NATH complexes with hARD1 in a ribosomal associated protein-N-acetyltransferase complex. PMID: 15496142

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
  • 組織特異性：
    Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, u
  • 數據庫鏈接：

    HGNC: 30782

    OMIM: 608000

    KEGG: hsa:80155

    STRING: 9606.ENSP00000296543

    UniGene: Hs.745047



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