在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MYO10 Antibody

  • 中文名稱:
    MYO10兔多克隆抗體
  • 貨號:
    CSB-PA884628LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA884628LA01HU at dilution of 1:100
    • Immunofluorescent analysis of U251 cells using CSB-PA884628LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MYO10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AW048724 antibody; D15Ertd600e antibody; FLJ10639 antibody; FLJ21066 antibody; FLJ22268 antibody; FLJ43256 antibody; KIAA0799 antibody; MGC131988 antibody; mKIAA0799 antibody; MYO10 antibody; MYO10_HUMAN antibody; Myosin X antibody; Myosin-X antibody; OTTMUSP00000022066 antibody; Unconventional myosin 10 antibody; Unconventional myosin X antibody; Unconventional myosin-10 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Unconventional myosin-X protein (1-97AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,MYO10 Antibody (CSB-PA884628LA01HU),的標記方式是Non-conjugated。對于MYO10 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA884628LB01HU MYO10 Antibody, HRP conjugated ELISA
    FITC CSB-PA884628LC01HU MYO10 Antibody, FITC conjugated
    Biotin CSB-PA884628LD01HU MYO10 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.; Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion.
  • 基因功能參考文獻:
    1. miR-129 inhibited neuroblastoma growth and potentiated chemosensitivity by targeting MYO10 PMID: 29864913
    2. In two cohorts with available data, we identified one intronic SNP (rs13361131) in myosin X gene (MYO10) associated with C17:0 level (P = 1.37x10-8), and two intronic SNP (rs12874278 and rs17363566) in deleted in lymphocytic leukemia 1 (DLEU1) region associated with C19:0 level (P = 7.07x10-9) PMID: 29738550
    3. MYO10 (myosin X), a direct miR340 target gene, mediated the migration and invasion of breast cancer cells PMID: 26573744
    4. Results suggest that NF-kappaB-regulated miR-124 targets MYO10, inhibits cell invasion and metastasis, and is down-regulated in node-positive NSCLC. PMID: 25749519
    5. Myo10 plays a key role in integrating the actin and microtubule cytoskeletons to position centrosomes and mitotic spindles. PMID: 26235048
    6. New research implicates Myo10 in a number of disease states including cancer metastasis and pathogen infection. PMID: 25819274
    7. PCTK1 regulates spindle orientation through phosphorylation of Ser83 on KAP0, a regulatory subunit of protein kinase A. PMID: 25605337
    8. Elevated MYO10 expression and involvement in invadopodia formation increases the aggressiveness of breast cancer . PMID: 24921915
    9. Study demonstrates a novel biological function for Hdl-Myo10 and an important new role for both Myo10 isoforms in the development of dendritic spines and synapses. PMID: 23943878
    10. Myo10 upregulation in mutant p53-driven cancers is necessary for invasion and that plasma-membrane protrusions. PMID: 24487586
    11. Phosphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin-X (Myo10). PMID: 24379415
    12. Authors conclude thatMyo10 generates the force to enhance bacterial-induced cell membrane protrusions by binding its head region to actin filaments and its PH tail domain to the peripheral membrane. PMID: 23083060
    13. Molecular basis by which myosin-X facilitates alternative dual binding to cargos and microtubules. PMID: 21642953
    14. The structure of the MyoX MyTH4-FERM tandem in complex with the cytoplasmic tail P3 domain of the netrin receptor DCC, is reported. PMID: 21321230
    15. Results indicate that PtdIns(3,4,5)P binding to the Myo10-PH2 domain is involved in Myo10 trafficking and regulation of filopodia dynamics. PMID: 20930142
    16. Results suggest that VE-cadherin trafficking along filopodia using myosin-X motor protein is a prerequisite for cell-cell junction formation. PMID: 20123970
    17. M10 is a specific motor carrying Mena/VASP from the root to the tip of the filopodia where extension of actin filament takes place PMID: 15158464
    18. Results report that, in addition to full-length myosin 10 (Myo10), brain expresses a shorter form of Myo10 that lacks a myosin head domain. PMID: 16371656
    19. Data demonstrate that Myo10 is a molecular motor that functions in filopodia formation. PMID: 16894163
    20. Our data suggest that CLP functions to increase translation of Myo10 possibly by acting as a chaperone for the emerging Myo10 heavy chain protein. PMID: 18295593
    21. myosin X recognizes the local structural arrangement of filaments in long bundles, providing a mechanism for sorting cargo to distant target sites. PMID: 18599451
    22. increased CLP expression and CLP-mediated Myo10 function are important for skin differentiation and wound reepithelialization PMID: 18818677

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Cell projection, filopodium tip. Cytoplasm, cell cortex. Cell projection, filopodium membrane; Peripheral membrane protein. Note=May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 7593

    OMIM: 601481

    KEGG: hsa:4651

    STRING: 9606.ENSP00000421280

    UniGene: Hs.481720



主站蜘蛛池模板: 2022国产成人精品视频人| 在线 国产 精品 蜜芽| 亚洲日本va中文字幕亚洲| 人妻少妇精品久久久久久| 久久精品蜜芽亚洲国产av| 国模少妇一区二区三区| 久久综合给合久久国产免费 | 加勒比中文无码久久综合色| 午夜福利无码不卡在线观看| 国产偷人妻精品一区| 午夜亚洲乱码伦小说区69堂| 国产美女精品中文网蜜芽宝贝| 真实的国产乱xxxx| 啦啦啦中文在线观看日本| 99re久久资源最新地址| 色综合无码av网站| 在线亚洲人成电影网站色www| 国产午夜福利100集发布| 国产一区二区三区在线视頻| 国产卡1卡2卡3麻豆精品免费 | 强奷人妻日本中文字幕| 精品亚洲国产成人a片app| 日本大片免费观看视频| 亚洲男女一区二区三区 | 色窝窝免费一区二区三区| 成人免费一区二区三区视频| 亚洲亚洲人成无码网www| 狠狠色丁香久久综合婷婷| 射死你天天日| 黄页网站在线观看免费视频| 在线亚洲专区高清中文字幕| 欧美日韩在线亚洲综合国产人| 欧美大片va欧美在线播放| 欧洲精品一卡2卡三卡4卡影视| 粗大黑人巨精大战欧美成人| 国产9 9在线 | 中文| 国产一区二区三区精品av| 人妻熟女一区二区aⅴ清水理纱| 性欧美大胆免费播放| 人妻少妇乱子伦精品| 无码av专区丝袜专区|