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  4. MTERF1 Antibody

MTERF1 Antibody

  • 中文名稱：
    MTERF1兔多克隆抗體
  • 貨號：
    CSB-PA811872LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: HL60 whole cell lysate, K562 whole cell lysate
      All lanes: MTERF1 antibody at 2.6μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46 kDa
      Observed band size: 46 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MTERF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MTERF1
  • 別名：
    mitochondrial antibody; Mitochondrial transcription termination factor 1 antibody; mTERF antibody; MTERF_HUMAN antibody; Transcription termination factor antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription termination factor 1, mitochondrial protein (63-232AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MTERF1 Antibody (CSB-PA811872LA01HU)，的標記方式是Non-conjugated。對于MTERF1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA811872LB01HU MTERF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA811872LC01HU MTERF1 Antibody, FITC conjugated
    Biotin CSB-PA811872LD01HU MTERF1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.
  • 基因功能參考文獻：
    1. MTERF1 has the ability to accommodate alternate active conformations. PMID: 26523681
    2. It has been demonstrated that MTERF1 arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE. PMID: 27112570
    3. Studies indicate that the structure of the mitochondrial transcription termination factor (MTERF1) provides insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination. PMID: 21326908
    4. Single nucleotide polymorphism in MTERF gene is associated with epithelial ovarian cancer. PMID: 21447778
    5. data suggested that hMTERF4 is an essential factor for cell proliferation, which is probably modulated by mitochondrial transcription to promote cell proliferation PMID: 21450691
    6. Data show that mTERF protein levels materially affect the amount of readthrough transcription on the antisense strand of mtDNA, whilst the effects on sense-strand transcripts are complex, and suggest the influence of compensatory mechanisms. PMID: 20846394
    7. Presented are the crystal structures of human mitochondrial regulator MTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. PMID: 20543826
    8. The structure indicates that upon sequence recognition MTERF1 unwinds the DNA molecule, promoting eversion of three nucleotides. PMID: 20550934
    9. mTERF mRNA levels were higher in elite athletes compared with moderately active subjects PMID: 19681768
    10. mTERF exists in mitochondria in two forms, an active monomer and an inactive large size complex PMID: 14744862
    11. monomeric human mTERF is fully active in its non-phosphorylated form and that the protein does not require additional cellular factors to terminate mitochondrial transcription in vitro PMID: 15899902
    12. analysis of DNA light-strand preferential recognition of human mitochondria transcription termination factor mTERF PMID: 16336784
    13. Results indicate a role for mTERF in mtDNA replication, in addition to its role in transcription. PMID: 17884915

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    MTERF family
  • 數據庫鏈接：

    HGNC: 21463

    OMIM: 602318

    KEGG: hsa:7978

    STRING: 9606.ENSP00000248643

    UniGene: Hs.532216



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