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  4. MOT1 Antibody

MOT1 Antibody

  • 中文名稱：
    MOT1 Antibody
  • 貨號(hào)：
    CSB-PA329158XA01SVG
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:MOT1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 26.5 kDa
      Observed band size: 27 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MOT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MOT1
  • 別名：
    TATA-binding protein-associated factor MOT1 (TBP-associated factor MOT1) (EC 3.6.4.-) (Modifier of transcription 1) MOT1 YPL082C LPF4C
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 免疫原：
    Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MOT1 protein (1284-1457aa)
  • 免疫原種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity.
  • 基因功能參考文獻(xiàn)：
    1. these results suggest that TBP-DNA affinity as well as other aspects of promoter sequence influence Mot1 function in vivo. PMID: 27255709
    2. The results stress the importance of the cooperation of Mot1p/NC2 with remodelers in maintaining a repressive environment for intragenic transcription. PMID: 24459134
    3. The action of Mot1 is required to clear TBP from intrinsically preferred (TATA-containing) binding sites, ensuring sufficient soluble TBP to bind intrinsically disfavored (TATA-less) sites. PMID: 24144978
    4. In the absence of ATP, ternary complex stability arises from both Mot1-DNA and Mot1-TBP interactions. PMID: 22298788
    5. findings suggest that the four conserved regions of Mot1 are essential for viability and required for proper regulation of most Mot1-regulated genes; loss of the ATPase domain, however, imparts some unexpected regulation on certain genes PMID: 21444714
    6. Mot1 plays a broad role in establishing the precision and efficiency of RNA synthesis. PMID: 20855454
    7. MOT1 might have a role in vivo as a transcriptional activator in the small ubiquitin-related modifier (SUMO) protein pathway. PMID: 16387868
    8. A novel ATP-independent TBPc displacement activity for Mot1 is reported PMID: 16541100
    9. These results support a model in which Mot1 affects the rate and efficiency of rRNA synthesis by both direct and indirect mechanisms, with resulting effects on transcription activation and the coupling of rRNA synthesis to processing. PMID: 17296733
    10. Mot1p interacts with a range of transcriptional co-regulators as well as proteins involved in chromatin remodeling. PMID: 18596064
    11. Mot1-mediated dissociation of TBP (or TBP-containing complexes) from chromatin can explain the Mot1 activation mechanism at some promoters. PMID: 19098311
    12. These results therefore demonstrate that Mot1 is an in vivo SUMO-targeted ubiquitin ligase target in yeast and suggest a role for SUMO-targeted degradation in protein quality control. PMID: 19139279

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  • 亞細(xì)胞定位：
    Mitochondrion. Nucleus. Note=Localized on chromatin. Specifically localized to the promoters of the genes it regulates.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: sce:YPL082C

    STRING: 4932.YPL082C



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