在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MLST8 Antibody, HRP conjugated

  • 中文名稱:
    MLST8兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA863130LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MLST8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    G protein beta subunit like antibody; G protein beta subunit-like antibody; Gable antibody; GbetaL antibody; GBL antibody; GBL protein antibody; LST8 antibody; LST8_HUMAN antibody; Mammalian lethal with SEC13 protein 8 antibody; MGC111011 antibody; mLST8 antibody; MTOR associated protein LST8 homolog (S. cerevisiae) antibody; POP3 antibody; POP3 homolog (S. pombe) antibody; Protein GbetaL antibody; Target of rapamycin complex subunit LST8 antibody; TORC subunit LST8 antibody; WAT1 antibody; WAT1 homolog (S. pombe) antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Target of rapamycin complex subunit LST8 protein (159-220AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
  • 基因功能參考文獻(xiàn):
    1. NEAT1 was potentially communicated with mTOR signaling target protein mLST8 via the association with miR-181b in type 2 diabetes mellitus. PMID: 28643459
    2. Autophagy regulates c-MET phosphorylation via an mTORC2-dependent mechanism. PMID: 28475179
    3. Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. PMID: 26787466
    4. MLST8 upregulation may contribute to tumor progression. PMID: 25906254
    5. MLST8 polymorphism is associated with gastric cancer. PMID: 23423739
    6. The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8. PMID: 23594158

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    WD repeat LST8 family
  • 組織特異性:
    Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24825

    OMIM: 612190

    KEGG: hsa:64223

    STRING: 9606.ENSP00000380313

    UniGene: Hs.29203



主站蜘蛛池模板: 久久久97丨国产人妻熟女| 狠狠躁夜夜躁人人爽天天古典| 女人与牲口性恔配视频免费| 在线视频国产制服丝袜| 国产亚洲精品久久久久四川人 | 国产亚洲欧美精品永久| 国产成人欧美综合在线影院| 黑人巨茎大战欧美白妇免费| 精品国产一区二区三区国产区| 我的性奴的肉玩具1一17心奴| 人妻丰满熟妇aⅴ无码| 99re6热在线精品视频观看| 日韩精品一区二区大桥未久| 无码高潮喷水在线观看| 国产精品久久久久久亚洲| 久久亚洲美女精品国产精品 | 日日碰狠狠丁香久燥| 肥臀浪妇太爽了快点再快点| 亚洲一卡2卡3卡4卡国产| 亚洲精品少妇一区二区 | 日韩亚洲欧美精品综合| 亚洲爆乳大丰满无码专区| 成人看的污污超级黄网站免费| 天天躁日日躁狠狠躁人妻| 特级毛片a片久久久久久| 国产成人无码专区| 欧美成aⅴ人高清怡红院| 久久99精品国产免费观观| 在线看片人成视频免费无遮挡| 亚洲国产一区二区波多野结衣 | 久久大香线蕉国产精品免费| 性一交一黄一片| 99久久国产综合精品swag| 亚洲成av人片天堂网久久| 成人午夜特黄aaaaa片男男| 国产精品免费精品自在线观看| 欧美成人精品三级一二三在线观看 | 久久天天躁夜夜躁狠狠85麻豆| av网站免费线看精品| 国内精品2020情侣视频| 国产午夜亚洲精品不卡下载|