在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MLST8 Antibody, HRP conjugated

  • 中文名稱:
    MLST8兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA863130LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MLST8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    G protein beta subunit like antibody; G protein beta subunit-like antibody; Gable antibody; GbetaL antibody; GBL antibody; GBL protein antibody; LST8 antibody; LST8_HUMAN antibody; Mammalian lethal with SEC13 protein 8 antibody; MGC111011 antibody; mLST8 antibody; MTOR associated protein LST8 homolog (S. cerevisiae) antibody; POP3 antibody; POP3 homolog (S. pombe) antibody; Protein GbetaL antibody; Target of rapamycin complex subunit LST8 antibody; TORC subunit LST8 antibody; WAT1 antibody; WAT1 homolog (S. pombe) antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Target of rapamycin complex subunit LST8 protein (159-220AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
  • 基因功能參考文獻(xiàn):
    1. NEAT1 was potentially communicated with mTOR signaling target protein mLST8 via the association with miR-181b in type 2 diabetes mellitus. PMID: 28643459
    2. Autophagy regulates c-MET phosphorylation via an mTORC2-dependent mechanism. PMID: 28475179
    3. Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. PMID: 26787466
    4. MLST8 upregulation may contribute to tumor progression. PMID: 25906254
    5. MLST8 polymorphism is associated with gastric cancer. PMID: 23423739
    6. The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8. PMID: 23594158

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    WD repeat LST8 family
  • 組織特異性:
    Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24825

    OMIM: 612190

    KEGG: hsa:64223

    STRING: 9606.ENSP00000380313

    UniGene: Hs.29203



主站蜘蛛池模板: 免费夫妻生活片av| 国产成人av一区二区三区不卡| 国产又粗又猛又爽又黄的视频在线观看动漫 | 日射精情感性色视频| 国产精品第一区揄拍无码| 肥臀熟女一区二区三区| 凹凸国产熟女精品视频app| 妺妺窝人体色777777| 欧美韩中文精品有码视频在线| av国産精品毛片一区二区视频| 久久免费看少妇高潮v片特黄| 无码av高潮抽搐流白浆| 97国产精品麻豆性色aⅴ人妻波| 欧美日韩人成视频在线播放| 国产v亚洲v天堂无码| 久久棈精品久久久久久噜噜| 国产9 9在线 | 中文| 三上悠亚精品一区二区久久| 狠狠躁夜夜躁人人爽天天bl| 最近最新中文字幕高清免费| av免费网址在线观看| 国产精品国产三级国产普通话| 麻豆果冻精东九一传媒mv| 欧美成人无码a区视频在线观看| 亚洲无av在线中文字幕| 自愉自愉产区二十四区| 女乱高潮久久久久久爽爽| 国产超碰人人做人人爱一二区视品| 亚洲hdmi高清线| 久久精品国产清自在天天线| 国产亚洲成av片在线观看| 成年无码av片在线免缓冲| 国产两女互慰高潮视频在线观看| 亚洲成av人片一区二区梦乃| 曰本女人与公拘交酡| 午夜在线a亚洲v天堂网2018| 国产超碰人人做人人爱| 人人妻人人澡人人爽精品日本| 女人和拘做爰正片视频| 国产成人无码va在线观看| 亚洲最大无码av网站观看|