在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MLST8 Antibody, Biotin conjugated

  • 中文名稱:
    MLST8兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA863130LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MLST8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    G protein beta subunit like antibody; G protein beta subunit-like antibody; Gable antibody; GbetaL antibody; GBL antibody; GBL protein antibody; LST8 antibody; LST8_HUMAN antibody; Mammalian lethal with SEC13 protein 8 antibody; MGC111011 antibody; mLST8 antibody; MTOR associated protein LST8 homolog (S. cerevisiae) antibody; POP3 antibody; POP3 homolog (S. pombe) antibody; Protein GbetaL antibody; Target of rapamycin complex subunit LST8 antibody; TORC subunit LST8 antibody; WAT1 antibody; WAT1 homolog (S. pombe) antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Target of rapamycin complex subunit LST8 protein (159-220AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
  • 基因功能參考文獻:
    1. NEAT1 was potentially communicated with mTOR signaling target protein mLST8 via the association with miR-181b in type 2 diabetes mellitus. PMID: 28643459
    2. Autophagy regulates c-MET phosphorylation via an mTORC2-dependent mechanism. PMID: 28475179
    3. Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. PMID: 26787466
    4. MLST8 upregulation may contribute to tumor progression. PMID: 25906254
    5. MLST8 polymorphism is associated with gastric cancer. PMID: 23423739
    6. The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8. PMID: 23594158

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    WD repeat LST8 family
  • 組織特異性:
    Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24825

    OMIM: 612190

    KEGG: hsa:64223

    STRING: 9606.ENSP00000380313

    UniGene: Hs.29203



主站蜘蛛池模板: 成 人色 网 站 欧美大片在线观看| 国产在线无码播放不卡视频| 亚洲精品久久66国产高清| 亚洲熟妇丰满xxxxx| 亚洲国产丝袜精品一区| 无码国产色欲xxxxx视频| 亚洲爆乳无码精品aaa片蜜桃| 无码av天堂一区二区三区| 欧洲美熟女乱又伦免费视频| 久久se精品一区二区三区| 国产精品久久久久蜜芽| 精品香蕉一区二区三区| 日本高清www午色夜com | 青青草无码伊人久久| 四虎国产精品永久在线无码| 国产精品成人午夜久久| 亚洲精品一区久久久久一品av| 欧妇女乱妇女乱视频| 忍着娇喘人妻被中出中文字幕 | 国产精品三级av及在线观看| 久久精品人妻无码专区| 国产精品成人av片免费看| 成人麻豆日韩在无码视频| 男人猛戳女人30分钟视频大全| 亚洲精品无码少妇30p| 亚洲一区二区三区尿失禁| 18禁免费观看网站| 无码国产成人午夜视频在线播放| 韩国精品久久久久久无码| 中文字幕日韩一区二区不卡| 色综合久久蜜芽国产精品| 网友自拍区视频精品| 国内精品乱码卡一卡2卡三卡新区 亚洲爆乳成av人在线视菜奈实 | 亚洲成av大片大片在线播放| 国产亚洲精品第一综合另类| 里番本子纯肉侵犯肉全彩无码| 香蕉成人伊视频在线观看| 大香伊蕉在人线国产最新75| 日韩在线成年视频人网站观看| 麻豆精品久久久久久久99蜜桃| 欧美野外疯狂做受xxxx高潮|