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MIS12 Antibody

  • 中文名稱：
    MIS12兔多克隆抗體
  • 貨號：
    CSB-PA875639LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: MIS12 antibody at 2μg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 25 kDa
      Observed band size: 25 kDa
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA875639LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA875639LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MIS12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MIS12
  • 別名：
    MIS12 antibody; Protein MIS12 homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein MIS12 homolog protein (1-305AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MIS12 Antibody (CSB-PA875639LA01HU)，的標記方式是Non-conjugated。對于MIS12 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA875639LB01HU MIS12 Antibody, HRP conjugated ELISA
    FITC CSB-PA875639LC01HU MIS12 Antibody, FITC conjugated
    Biotin CSB-PA875639LD01HU MIS12 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
  • 基因功能參考文獻：
    1. Whereas CENP-C recruits a single MIS12:NDC80 complex, the authors show here that CENP-T binds one MIS12:NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1:Cyclin B complex at three distinct CENP-T sites. PMID: 28012276
    2. RWD-containing proteins interact with the Mis12 complex to shape KMN network topology, as revealed by structural analysis PMID: 24530301
    3. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. PMID: 21353556
    4. These findings support a novel role for Hsp90-Sgt1 chaperones in ensuring the fidelity of Mis12 multiprotein complex assembly. PMID: 20404110
    5. hMIS12 has a role in mitosis and localizes at kinetochores PMID: 12515822
    6. These results indicate that a four-subunit Mis12 complex plays an essential role in chromosome segregation in vertebrates and contributes to mitotic kinetochore assembly. PMID: 16585270

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  • 亞細胞定位：
    Chromosome, centromere, kinetochore.
  • 蛋白家族：
    Mis12 family
  • 數據庫鏈接：

    HGNC: 24967

    OMIM: 609178

    KEGG: hsa:79003

    STRING: 9606.ENSP00000370557

    UniGene: Hs.267194



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