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  4. MINK1 Antibody

MINK1 Antibody

  • 中文名稱：
    MINK1兔多克隆抗體
  • 貨號：
    CSB-PA170472
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COLO cells, using MAP4K6 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MINK1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MINK1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human MAP4K6.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
  • 基因功能參考文獻：
    1. MINK plays a functional role in the IRES-mediated translation of EV71 viral RNA and may provide a potential target for the development of specific antiviral strategies against EV71 infection PMID: 25747578
    2. Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. PMID: 22665485
    3. MINK1 interacts with and phosphorylates PRICKLE1 and PRICKLE2. PMID: 22037766
    4. MINK interaction with Rap2 plays a critical role in maintaining the morphological integrity of dendrites and synaptic transmission. PMID: 21048137
    5. Analysis of the coding region of the NIK gene in progressive supranuclear palsy (PSP) patients through single strand conformation polymorphism and direct sequencing does not support a pathogenic role of the NIK gene in PSP. PMID: 12668260
    6. results suggest that human Misshapen/NIKs-related kinase beta (hMINK beta) plays an important role in cytoskeleton reorganization, cell adhesion, and cell motility(hMINKbeta) PMID: 15469942

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  • 亞細胞定位：
    Cytoplasm. Cell junction, synapse, postsynaptic density. Cell projection, axon. Cell projection, dendrite.; [Isoform 4]: Golgi apparatus.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas an
  • 數據庫鏈接：

    HGNC: 17565

    OMIM: 609426

    KEGG: hsa:50488

    STRING: 9606.ENSP00000347427

    UniGene: Hs.443417



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