在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MIEN1 Antibody, FITC conjugated

  • 中文名稱:
    MIEN1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA874795LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MIEN1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MIEN1
  • 別名:
    C17orf37 antibody; C17orf37 homolog antibody; C35 antibody; chromosome 17 open reading frame 37 antibody; HBV X transactivated gene 4 protein antibody; HBV X-transactivated gene 4 protein antibody; HBV XAg transactivated protein 4 antibody; HBV XAg-transactivated protein 4 antibody; MGC14832 antibody; Mien1 antibody; MIEN1_HUMAN antibody; Migration and invasion enhancer 1 antibody; ORB3 antibody; Protein C17orf37 antibody; Protein C35 antibody; RDX12 antibody; Redox protein, 12-KD antibody; XTP4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Migration and invasion enhancer 1 protein (2-112AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
  • 基因功能參考文獻:
    1. these results suggest the MIEN1 promoter has a short interspersed nuclear Alu element region that is hypermethylated in normal cells leading to repression of the gene; in cancer, the hypomethylation of a part of this repeat, in addition to the binding of USF, results in MIEN1 expression PMID: 27589566
    2. Data show that migration and invasion enhancer 1 (MIEN1) plays an essential role in maintaining the plasticity of the dynamic membrane-associated actin cytoskeleton, which leads to an increase in cell motility, suggesting targeting MIEN1 might represent a promising means to prevent breast tumor metastasis. PMID: 27462783
    3. Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells. PMID: 28859163
    4. indicate that MIEN1 overexpression may facilitate migration and invasion in breast cancer PMID: 28198505
    5. In conclusion, this study revealed that miR-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment. PMID: 26827826
    6. MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. PMID: 26272794
    7. MIEN1 expression not only positively correlates with oral cancer progression but also seems to be a critical molecular determinant in migration and invasion of oral cancer cells. PMID: 25996585
    8. C35 might serve as a biomarker or therapeutic target for management of colorectal cancer. PMID: 26173296
    9. While MIEN1 is a direct target of miR-940, miR-940 alters MIEN1 RNA. PMID: 25406943
    10. results suggest that DeltaNp73 might cooperate with C35 to promote tumour progression and contribute to cisplatin resistance in ovarian cancer cells. PMID: 23880825
    11. Results suggest that MIEN1 may have an important regulatory role in phosphorylation of AKT with its redox potential. PMID: 23284973
    12. prenylation is required for the function of the C17orf37 protein in cancer cells PMID: 21628459
    13. Inhibition of C35 gene expression by small interfering RNA induces apoptosis of breast cancer cells. PMID: 21068479
    14. Data strongly suggest C17orf37 overexpression in prostate cancer functionally enhances migration and invasion of tumor cells, and is an important target for cancer therapy. PMID: 19503095
    15. MGC14832 gene is located within human chromosome 17q12 amplicon, including PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes. PPP1R1B ~ ERBB2 ~ GRB7 locus is amplified in human gastric cancer and breast cancer. PMID: 12739007

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
  • 蛋白家族:
    SelWTH family
  • 組織特異性:
    Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein le
  • 數據庫鏈接:

    HGNC: 28230

    OMIM: 611802

    KEGG: hsa:84299

    STRING: 9606.ENSP00000377778

    UniGene: Hs.333526



主站蜘蛛池模板: 亚洲人成无码网www电影麻豆| 777久久精品一区二区三区无码 | 亚洲肥老太bbw中国熟女| 少妇性bbb搡bbb爽爽爽欧美| 黄页网站视频| 亚洲精品无码你懂的| 亚洲欧美日韩国产国产a| 午夜视频体内射.com.com| 成人性生交大片免费看小说| 一区二区三区鲁丝不卡麻豆 | 国产精品99久久精品爆乳| 国产jjzzjjzz视频全部免费| 免费啪视频在线观看视频日本| 少妇又色又紧又爽又刺激视频 | 国产成人精品日本亚洲网站| 亚洲精品无码久久久久| 日本精品中文字幕在线播放| 成人无码a∨电影免费| 黑人巨茎大战白人美女| 色狠狠一区二区三区香蕉| 亚洲欧洲国产综合aⅴ无码| 永久免费看啪啪网址入口| 国产成人久久精品一区二区三区| 国产成人福利美女观看视频| 中文字幕一区日韩精品| 无码人妻精品一区二区蜜桃色欲| 人妻少妇heyzo无码专区| 欧美国产伦久久久久久久| 天堂中文官网在线| 午夜射精日本三级| 国产末成年av在线播放| 免费国产高清在线精品一区| 麻麻张开腿让我爽了一夜| 欧美丰腴丰满大屁股熟妇| 人人澡人人澡人人看添| 欧美日本韩国亚洲| 伊人狠狠色丁香婷婷综合| 好爽太紧了舒服视频| 亚洲一区二区三区尿失禁| 亚洲国产精品久久网午夜| 在线视频国产网址你懂的|