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  4. MIEN1 Antibody, Biotin conjugated

MIEN1 Antibody, Biotin conjugated

  • 中文名稱：
    MIEN1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA874795LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MIEN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MIEN1
  • 別名：
    C17orf37 antibody; C17orf37 homolog antibody; C35 antibody; chromosome 17 open reading frame 37 antibody; HBV X transactivated gene 4 protein antibody; HBV X-transactivated gene 4 protein antibody; HBV XAg transactivated protein 4 antibody; HBV XAg-transactivated protein 4 antibody; MGC14832 antibody; Mien1 antibody; MIEN1_HUMAN antibody; Migration and invasion enhancer 1 antibody; ORB3 antibody; Protein C17orf37 antibody; Protein C35 antibody; RDX12 antibody; Redox protein, 12-KD antibody; XTP4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Migration and invasion enhancer 1 protein (2-112AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
  • 基因功能參考文獻：
    1. these results suggest the MIEN1 promoter has a short interspersed nuclear Alu element region that is hypermethylated in normal cells leading to repression of the gene; in cancer, the hypomethylation of a part of this repeat, in addition to the binding of USF, results in MIEN1 expression PMID: 27589566
    2. Data show that migration and invasion enhancer 1 (MIEN1) plays an essential role in maintaining the plasticity of the dynamic membrane-associated actin cytoskeleton, which leads to an increase in cell motility, suggesting targeting MIEN1 might represent a promising means to prevent breast tumor metastasis. PMID: 27462783
    3. Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells. PMID: 28859163
    4. indicate that MIEN1 overexpression may facilitate migration and invasion in breast cancer PMID: 28198505
    5. In conclusion, this study revealed that miR-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment. PMID: 26827826
    6. MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. PMID: 26272794
    7. MIEN1 expression not only positively correlates with oral cancer progression but also seems to be a critical molecular determinant in migration and invasion of oral cancer cells. PMID: 25996585
    8. C35 might serve as a biomarker or therapeutic target for management of colorectal cancer. PMID: 26173296
    9. While MIEN1 is a direct target of miR-940, miR-940 alters MIEN1 RNA. PMID: 25406943
    10. results suggest that DeltaNp73 might cooperate with C35 to promote tumour progression and contribute to cisplatin resistance in ovarian cancer cells. PMID: 23880825
    11. Results suggest that MIEN1 may have an important regulatory role in phosphorylation of AKT with its redox potential. PMID: 23284973
    12. prenylation is required for the function of the C17orf37 protein in cancer cells PMID: 21628459
    13. Inhibition of C35 gene expression by small interfering RNA induces apoptosis of breast cancer cells. PMID: 21068479
    14. Data strongly suggest C17orf37 overexpression in prostate cancer functionally enhances migration and invasion of tumor cells, and is an important target for cancer therapy. PMID: 19503095
    15. MGC14832 gene is located within human chromosome 17q12 amplicon, including PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes. PPP1R1B ~ ERBB2 ~ GRB7 locus is amplified in human gastric cancer and breast cancer. PMID: 12739007

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  • 亞細胞定位：
    Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
  • 蛋白家族：
    SelWTH family
  • 組織特異性：
    Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein le
  • 數據庫鏈接：

    HGNC: 28230

    OMIM: 611802

    KEGG: hsa:84299

    STRING: 9606.ENSP00000377778

    UniGene: Hs.333526



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