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  4. MIEF1 Antibody

MIEF1 Antibody

  • 中文名稱：
    MIEF1兔多克隆抗體
  • 貨號：
    CSB-PA021827GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MIEF1
  • 別名：
    MIEF1 antibody; MID51 antibody; SMCR7L antibody; Mitochondrial dynamics protein MID51 antibody; Mitochondrial dynamics protein of 51 kDa antibody; Mitochondrial elongation factor 1 antibody; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like antibody; SMCR7-like protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SMCR7L
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
  • 基因功能參考文獻：
    1. MiD51 inhibits Drp1, whereas ADP promotes MiD51-mediated fission. [review] PMID: 27660309
    2. The results indicate that Drp1-dependent mitochondrial fission through MiD49/MiD51 regulates cristae remodeling during intrinsic apoptosis. PMID: 26903540
    3. The cytoplasmic domain of MiD51 was overexpressed, purified and crystallized. PMID: 24817717
    4. MIEF1 and MIEF2 are differentially expressed in human tissues during development PMID: 23880462
    5. MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria. PMID: 23921378
    6. we find that either MiD49 or MiD51 can mediate Drp1 recruitment and mitochondrial fission in the absence of Fis1 and Mff PMID: 23283981
    7. elevated MIEF1 levels induce mitochondrial fusion; depletion of MIEF1 causes mitochondrial fragmentation; MIEF1 interacts with and recruits Drp1 to mitochondria but inhibits Drp1 activity, executing a negative effect on mitochondrial fission PMID: 21701560
    8. MiD49/51 are new mediators of mitochondrial division affecting Drp1 action at mitochondria. PMID: 21508961
    9. Mitochondrial outer membrane protein that recruits fission mediator Drp1 to the mitochondrial surface. PMID: 21508961

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  • 亞細胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein.
  • 蛋白家族：
    SMCR7 family
  • 組織特異性：
    Expression is relatively high in heart, skeletal muscle, pancreas and kidney.
  • 數據庫鏈接：

    HGNC: 25979

    OMIM: 615497

    KEGG: hsa:54471

    STRING: 9606.ENSP00000327124

    UniGene: Hs.728085



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