在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MGAT3 Antibody

MGAT3 Antibody

  • 中文名稱：
    MGAT3兔多克隆抗體
  • 貨號：
    CSB-PA013775GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MGAT3
  • 別名：
    4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase antibody; Beta 1 4 mannosyl glycoprotein 4 beta N acetylglucosaminyltransferase antibody; Beta-1 antibody; FLJ43371 antibody; GlcNAc T III antibody; GlcNAc-T III antibody; GNT 3 antibody; GNT III antibody; GNT-III antibody; GNT3 antibody; Mannosyl (beta 1 4 ) glycoprotein beta 1 4 N acetylglucosaminyltransferase antibody; MGAT 3 antibody; MGAT3 antibody; MGAT3_HUMAN antibody; MGC141943 antibody; MGC142278 antibody; N acetylglucosaminyltransferase III antibody; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase III antibody; N-acetylglucosaminyltransferase III antibody; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III antibody; OTTHUMP00000042207 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MGAT3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate. Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location. Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation. In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage.
  • 基因功能參考文獻：
    1. Novel insights into the epigenetic regulation of MGAT3/bisecting GlcNAc and demonstrate the importance of N-glycosylation in cancer progression. PMID: 27429195
    2. Data suggest that GNT-III expression regulates levels/activation of the heavily glycosylated Notch receptor involved in normal and malignant cell development; suppression of GNT-III in epithelial ovarian carcinoma cell lines results in down-regulation of Notch signaling that is more potent than pharmacologic blockage of Notch activation. PMID: 28842505
    3. MGAT3 expressed in cells stimulates lipid droplet growth. These findings provide additional evidence that MGAT3 likely functions as a triacylglycerol synthase in cells. PMID: 27184406
    4. Core-fucosylated tetra-antennary structures were decreased in quantity likely as a result of hypomethylated MGAT3 gene promoter followed by increased expression of this gene PMID: 27073020
    5. High expression of alpha2,6-sialylation on the cell surface could affect the anti-migratory role of GnT-III, which provides an insight into the mechanistic roles of GnT-III in tumor metastasis. PMID: 26801611
    6. Mgat3 plays an important role in early spontaneous miscarriage in humans. PMID: 26109616
    7. MGAT3 protein and gene expression in in uveal and cutaneous melanoma cells PMID: 26098720
    8. HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc. PMID: 25936519
    9. GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion. PMID: 23671930
    10. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines PMID: 22451656
    11. MGAT3 mRNA biomarker may characterize subgroups of Alzheimer's disease patients with different disease progression. PMID: 21368380
    12. the modulation of glycosyltransferases MGAT3 and MGAT5 by synthetic N-acetyl-D-glucosamine-calix[4]arene correlated with the improvement of NK cell effector functions and the augmentation of tumor cells sensitivity to NK cell-mediated cytotoxicity. PMID: 20089585
    13. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production PMID: 19776078
    14. down-regulation of hydrogen peroxide-induced PKC delta activation in cells transfected with this enzyme PMID: 12427758
    15. MGAT3 and MGAT5 competitively modified E-cadherin N-glycans. PMID: 19403558

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 17 family
  • 數據庫鏈接：

    HGNC: 7046

    OMIM: 604621

    KEGG: hsa:4248

    STRING: 9606.ENSP00000345270

    UniGene: Hs.276808



主站蜘蛛池模板： 亚洲中文字幕久在线| 人妻丰满熟妇av无码区免| 人妻 丝袜美腿 中文字幕| 又色又爽又黄的吃奶视频免费观看| 无码被窝影院午夜看片爽爽jk| 波多野结衣初尝黑人| 人妻中文无码久热丝袜| 日本高清熟妇老熟妇| 国产精品99久久免费观看| 国产精品丝袜高跟鞋| 欧美成人精品第一区二区三区| 婷婷丁香六月激情综合在线人 | 国产欧美二区综合| 国产美女久久精品香蕉| 亚洲男人天堂| 久久99精品久久久久婷婷| 国产成人综合95精品视频| 欧美日韩一本的免费高清视频| 免费人成在线观看视频高潮| 国产免国产免‘费| 中文日产乱幕九区无线码| 吃奶呻吟打开双腿做受视频| 97久久超碰亚洲视觉盛宴 | 欧美综合自拍亚洲图久青草| 久久综合狠狠综合久久激情| 精品国产sm最大网免费站| 亚洲性色av一区二区三区| 综合欧美日韩国产成人| 国产成人无码av一区二区在线观看| 亚洲精品久久区二区三区蜜桃臀| 美女扒开奶罩露出奶头视频网站 | 成人午夜福利院在线观看| 激情按摩系列片aaaa| 18禁裸男晨勃露j毛免费观看| 野外少妇被弄到喷水在线观看| 色老99久久精品偷偷鲁| 曰韩人妻无码一区二区三区综合部| 在线无码中文字幕一区| 亚洲国产制服丝袜先锋| 日本乱子伦一区二区三区| 国产又色又爽又刺激视频|