在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MGAT3 Antibody

MGAT3 Antibody

  • 中文名稱：
    MGAT3兔多克隆抗體
  • 貨號：
    CSB-PA013775GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MGAT3
  • 別名：
    4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase antibody; Beta 1 4 mannosyl glycoprotein 4 beta N acetylglucosaminyltransferase antibody; Beta-1 antibody; FLJ43371 antibody; GlcNAc T III antibody; GlcNAc-T III antibody; GNT 3 antibody; GNT III antibody; GNT-III antibody; GNT3 antibody; Mannosyl (beta 1 4 ) glycoprotein beta 1 4 N acetylglucosaminyltransferase antibody; MGAT 3 antibody; MGAT3 antibody; MGAT3_HUMAN antibody; MGC141943 antibody; MGC142278 antibody; N acetylglucosaminyltransferase III antibody; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase III antibody; N-acetylglucosaminyltransferase III antibody; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III antibody; OTTHUMP00000042207 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MGAT3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate. Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location. Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation. In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage.
  • 基因功能參考文獻：
    1. Novel insights into the epigenetic regulation of MGAT3/bisecting GlcNAc and demonstrate the importance of N-glycosylation in cancer progression. PMID: 27429195
    2. Data suggest that GNT-III expression regulates levels/activation of the heavily glycosylated Notch receptor involved in normal and malignant cell development; suppression of GNT-III in epithelial ovarian carcinoma cell lines results in down-regulation of Notch signaling that is more potent than pharmacologic blockage of Notch activation. PMID: 28842505
    3. MGAT3 expressed in cells stimulates lipid droplet growth. These findings provide additional evidence that MGAT3 likely functions as a triacylglycerol synthase in cells. PMID: 27184406
    4. Core-fucosylated tetra-antennary structures were decreased in quantity likely as a result of hypomethylated MGAT3 gene promoter followed by increased expression of this gene PMID: 27073020
    5. High expression of alpha2,6-sialylation on the cell surface could affect the anti-migratory role of GnT-III, which provides an insight into the mechanistic roles of GnT-III in tumor metastasis. PMID: 26801611
    6. Mgat3 plays an important role in early spontaneous miscarriage in humans. PMID: 26109616
    7. MGAT3 protein and gene expression in in uveal and cutaneous melanoma cells PMID: 26098720
    8. HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc. PMID: 25936519
    9. GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion. PMID: 23671930
    10. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines PMID: 22451656
    11. MGAT3 mRNA biomarker may characterize subgroups of Alzheimer's disease patients with different disease progression. PMID: 21368380
    12. the modulation of glycosyltransferases MGAT3 and MGAT5 by synthetic N-acetyl-D-glucosamine-calix[4]arene correlated with the improvement of NK cell effector functions and the augmentation of tumor cells sensitivity to NK cell-mediated cytotoxicity. PMID: 20089585
    13. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production PMID: 19776078
    14. down-regulation of hydrogen peroxide-induced PKC delta activation in cells transfected with this enzyme PMID: 12427758
    15. MGAT3 and MGAT5 competitively modified E-cadherin N-glycans. PMID: 19403558

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 17 family
  • 數據庫鏈接：

    HGNC: 7046

    OMIM: 604621

    KEGG: hsa:4248

    STRING: 9606.ENSP00000345270

    UniGene: Hs.276808



主站蜘蛛池模板： aaa欧美色吧激情视频| 欧美粗大猛烈老熟妇| 久久精品成人免费观看三| 中国凸偷窥xxxx自由视频| 国产成人精品av| 久久精品中文字幕| 免费无码不卡中文字幕在线| 好硬好湿好爽好深视频| 国产99久久精品一区二区| 國产一二三内射在线看片| 无码精品国产dvd在线观看9久| 亚洲男人片片在线观看| 国产日产欧美最新| 鲁鲁鲁爽爽爽在线视频观看| 国产美女被遭高潮免费视频 | 亚洲乱码日产精品bd在线观看 | 久久ww精品w免费人成| 欧美成年视频在线观看 | 国内露脸中年夫妇交换| 火箭视频在线观看精品| 国产精品欧美久久久久无广告| 天天摸天天做天天爽水多| 国产精品熟妇视频国产偷人| 亚洲 综合 欧美 动漫 丝袜| 妲己丰满人熟妇大尺度人体艺| 亚洲色欲色欲www| 久久中文字幕人妻丝袜| 亚洲红杏成在人线免费视频| 日韩av高潮喷水在线观看| 毛片免费视频在线观看| 日韩视频在线观看| 日本亚洲vr欧美不卡高清专区| 久久天天躁狠狠躁夜夜2019| 欧美成人精品三级网站| 在线 无码 中文字幕 强 乱| 美女扒开腿让男人桶爽app免费看 精品国产免费人成电影在线看 | 粗大的内捧猛烈进出少妇视频| 日韩中文无码有码免费视频| 亚洲精品久久久久久一区二区| 欧美一道本一区二区三区| 嫩草研究院久久久精品|