在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MGAT3 Antibody, Biotin conjugated

MGAT3 Antibody, Biotin conjugated

  • 中文名稱：
    MGAT3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA22969D0Rb
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MGAT3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MGAT3
  • 別名：
    4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase antibody; Beta 1 4 mannosyl glycoprotein 4 beta N acetylglucosaminyltransferase antibody; Beta-1 antibody; FLJ43371 antibody; GlcNAc T III antibody; GlcNAc-T III antibody; GNT 3 antibody; GNT III antibody; GNT-III antibody; GNT3 antibody; Mannosyl (beta 1 4 ) glycoprotein beta 1 4 N acetylglucosaminyltransferase antibody; MGAT 3 antibody; MGAT3 antibody; MGAT3_HUMAN antibody; MGC141943 antibody; MGC142278 antibody; N acetylglucosaminyltransferase III antibody; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase III antibody; N-acetylglucosaminyltransferase III antibody; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III antibody; OTTHUMP00000042207 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase protein (435-533AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate. Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location. Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation. In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage.
  • 基因功能參考文獻：
    1. Novel insights into the epigenetic regulation of MGAT3/bisecting GlcNAc and demonstrate the importance of N-glycosylation in cancer progression. PMID: 27429195
    2. Data suggest that GNT-III expression regulates levels/activation of the heavily glycosylated Notch receptor involved in normal and malignant cell development; suppression of GNT-III in epithelial ovarian carcinoma cell lines results in down-regulation of Notch signaling that is more potent than pharmacologic blockage of Notch activation. PMID: 28842505
    3. MGAT3 expressed in cells stimulates lipid droplet growth. These findings provide additional evidence that MGAT3 likely functions as a triacylglycerol synthase in cells. PMID: 27184406
    4. Core-fucosylated tetra-antennary structures were decreased in quantity likely as a result of hypomethylated MGAT3 gene promoter followed by increased expression of this gene PMID: 27073020
    5. High expression of alpha2,6-sialylation on the cell surface could affect the anti-migratory role of GnT-III, which provides an insight into the mechanistic roles of GnT-III in tumor metastasis. PMID: 26801611
    6. Mgat3 plays an important role in early spontaneous miscarriage in humans. PMID: 26109616
    7. MGAT3 protein and gene expression in in uveal and cutaneous melanoma cells PMID: 26098720
    8. HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc. PMID: 25936519
    9. GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion. PMID: 23671930
    10. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines PMID: 22451656
    11. MGAT3 mRNA biomarker may characterize subgroups of Alzheimer's disease patients with different disease progression. PMID: 21368380
    12. the modulation of glycosyltransferases MGAT3 and MGAT5 by synthetic N-acetyl-D-glucosamine-calix[4]arene correlated with the improvement of NK cell effector functions and the augmentation of tumor cells sensitivity to NK cell-mediated cytotoxicity. PMID: 20089585
    13. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production PMID: 19776078
    14. down-regulation of hydrogen peroxide-induced PKC delta activation in cells transfected with this enzyme PMID: 12427758
    15. MGAT3 and MGAT5 competitively modified E-cadherin N-glycans. PMID: 19403558

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 17 family
  • 數據庫鏈接：

    HGNC: 7046

    OMIM: 604621

    KEGG: hsa:4248

    STRING: 9606.ENSP00000345270

    UniGene: Hs.276808



主站蜘蛛池模板： 国产真实伦在线观看| 国产亚洲精品久久久久久国| 综合三区后入内射国产馆| 国产精品 亚洲一区二区三区| 久久国国产免费999| 中文字幕av无码一区二区三区电影| 亚洲成av人片久久| 日韩人妻无码一区二区三区综合部| 国产天美传媒性色av出轨| 亚洲男人的天堂一区二区| 丰满熟妇被猛烈进入高清片| 亚洲日韩av无码中文字幕美国| 日本少妇高潮喷水免费可以看| 成人免费无码大片a毛片18| 天天躁日日躁aaaaxxxx| 国产精品秘入口18禁麻豆免会员| 亚洲v国产v欧美v久久久久久| 久久视频在线视频精品| 亚洲精品国男人在线视频| 日韩精品一区二区三区视频 | 国产精品久久久亚洲| 婷婷色爱区综合五月激情| 国产台湾无码av片在线观看| 日本饥渴人妻欲求不满| 亚洲精品一区国产欧美| 美女视频黄又黄又免费| 国产裸体舞一区二区三区| 久热在线中文字幕色999舞| 爽爽午夜影视窝窝看片| 久久综合婷婷丁香五月中文字幕| 日本伊人精品一区二区三区| 一本久道久久综合狠狠爱 | 亚洲乱码中文字幕综合234| 国产涩涩视频在线观看| 揉捏奶头高潮呻吟视频| 欧美成人精品午夜免费影视| 伊人久久综合色| 大战熟女丰满人妻av| 国产欧色美视频综合二区| 日本成本人片免费网站| 尤物yw193无码点击进入|