在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MED15 Antibody, HRP conjugated

MED15 Antibody, HRP conjugated

  • 中文名稱：
    MED15兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA842753LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MED15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MED15
  • 別名：
    MED15 antibody; ARC105 antibody; CTG7A antibody; PCQAP antibody; TIG1 antibody; TNRC7 antibody; Mediator of RNA polymerase II transcription subunit 15 antibody; Activator-recruited cofactor 105 kDa component antibody; ARC105 antibody; CTG repeat protein 7a antibody; Mediator complex subunit 15 antibody; Positive cofactor 2 glutamine/Q-rich-associated protein antibody; PC2 glutamine/Q-rich-associated protein antibody; TPA-inducible gene 1 protein antibody; TIG-1 antibody; Trinucleotide repeat-containing gene 7 protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Mediator of RNA polymerase II transcription subunit 15 protein (433-530AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
  • 基因功能參考文獻(xiàn)：
    1. MED15 does seem to play a tumour promoting role in the progression and metastatic spread of renal cell carcinoma PMID: 29400661
    2. MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K/Akt/mTOR signaling pathway in prostate cancer cells. PMID: 27974704
    3. MED15 as a potential biomarker for head and neck squamous cell carcinoma PMID: 26457685
    4. MED15 is differentially expressed in tumor-free testis and testicular germ cell tumors PMID: 26377566
    5. MED15 overexpression is a clonal event during head and neck squamous cell carcinoma progression. PMID: 25791637
    6. these findings implicate MED15 in CRPC, and as MED15 is evolutionary conserved, it is likely to emerge as a lethal phenotype in other therapeutic-resistant diseases, and not restricted to our disease model. PMID: 24374838
    7. MED15 and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 protein misfolding and proteotoxicity in vitro and in vivo. PMID: 22916034
    8. The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
    9. Methylation of TIG1 in prostatic neoplasms correlates with methylation of the retinoic acid receptor beta gene. PMID: 14691453
    10. Limited role of exon 7 PCQAP polymorphisms in the pathogenesis of schizophrenia. PMID: 15318033
    11. TIG1 gene Silencing by promoter hypermethylation is associated with nasopharyngeal carcinoma PMID: 15455391
    12. SREBPs use the evolutionarily conserved ARC105 (also called MED15) subunit to activate target genes PMID: 16799563
    13. results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling PMID: 16904669
    14. The protein encoded by this gene was identified as ARC105, a 105kDa component of the Activator-Recruited Cofactor (ARC) that is involved in mediating gene activation by several classes of transcriptional regulators. PMID: 10235267

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Mediator complex subunit 15 family
  • 組織特異性：
    Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and k
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14248

    OMIM: 607372

    KEGG: hsa:51586

    STRING: 9606.ENSP00000263205

    UniGene: Hs.517421



主站蜘蛛池模板： 天堂中文最新版在线中文| 无遮挡呻吟娇喘视频免费播放| 欧美破苞系列二十三| 国产成+人+综合+亚洲欧美丁香花| 中国少妇初尝黑人巨高清| 中文字幕av无码免费久久| 免费女人高潮流视频在线观看 | 天天躁日日躁狠狠躁av中文| 秋霞成人午夜鲁丝一区二区三区| 狠狠色噜噜狠狠狠狠色综合久| 在线aⅴ亚洲中文字幕| 人妻少妇偷人无码视频| 国产黄在线观看免费观看软件| 中国女人高潮hd| 国产精品久久久久久久久久久不卡| 24小时日本在线www免费的| 天天看片天天av免费观看| 精品人妻伦一二三区久久aaa片 | 亚洲综合久久成人a片红豆| 嫩草欧美曰韩国产大片| 欧美人妻精品一区二区三区| 日本乱妇乱子视频网站-百度| 大香伊蕉在人线国产网站首页| 国产成 人 综合 亚洲网站| 2021自拍偷在线精品自拍偷| 粗大的内捧猛烈进出在线视频| 99久久综合狠狠综合久久| 亚洲精品无码av中文字幕电影网站| 国产乱子伦一区二区三区视频播放 | 在线成人www免费观看视频| 人人做人人爽人人爱| 2020最新无码福利视频| 激情综合色综合啪啪五月丁香搜索 | 国产女人抽搐喷浆视频| 国产成人精品亚洲日本在线观看| 精品视频无码一区二区三区| 久久九九有精品国产23百花影院 | 99国产精品国产精品九九| 新版资源天堂中文| 色哟哟免费视频播放网站| 久久国产精品无码网站|