在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MED15 Antibody, FITC conjugated

MED15 Antibody, FITC conjugated

  • 中文名稱：
    MED15兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA842753LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MED15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MED15
  • 別名：
    MED15 antibody; ARC105 antibody; CTG7A antibody; PCQAP antibody; TIG1 antibody; TNRC7 antibody; Mediator of RNA polymerase II transcription subunit 15 antibody; Activator-recruited cofactor 105 kDa component antibody; ARC105 antibody; CTG repeat protein 7a antibody; Mediator complex subunit 15 antibody; Positive cofactor 2 glutamine/Q-rich-associated protein antibody; PC2 glutamine/Q-rich-associated protein antibody; TPA-inducible gene 1 protein antibody; TIG-1 antibody; Trinucleotide repeat-containing gene 7 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mediator of RNA polymerase II transcription subunit 15 protein (433-530AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
  • 基因功能參考文獻：
    1. MED15 does seem to play a tumour promoting role in the progression and metastatic spread of renal cell carcinoma PMID: 29400661
    2. MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K/Akt/mTOR signaling pathway in prostate cancer cells. PMID: 27974704
    3. MED15 as a potential biomarker for head and neck squamous cell carcinoma PMID: 26457685
    4. MED15 is differentially expressed in tumor-free testis and testicular germ cell tumors PMID: 26377566
    5. MED15 overexpression is a clonal event during head and neck squamous cell carcinoma progression. PMID: 25791637
    6. these findings implicate MED15 in CRPC, and as MED15 is evolutionary conserved, it is likely to emerge as a lethal phenotype in other therapeutic-resistant diseases, and not restricted to our disease model. PMID: 24374838
    7. MED15 and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 protein misfolding and proteotoxicity in vitro and in vivo. PMID: 22916034
    8. The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
    9. Methylation of TIG1 in prostatic neoplasms correlates with methylation of the retinoic acid receptor beta gene. PMID: 14691453
    10. Limited role of exon 7 PCQAP polymorphisms in the pathogenesis of schizophrenia. PMID: 15318033
    11. TIG1 gene Silencing by promoter hypermethylation is associated with nasopharyngeal carcinoma PMID: 15455391
    12. SREBPs use the evolutionarily conserved ARC105 (also called MED15) subunit to activate target genes PMID: 16799563
    13. results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling PMID: 16904669
    14. The protein encoded by this gene was identified as ARC105, a 105kDa component of the Activator-Recruited Cofactor (ARC) that is involved in mediating gene activation by several classes of transcriptional regulators. PMID: 10235267

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Mediator complex subunit 15 family
  • 組織特異性：
    Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and k
  • 數據庫鏈接：

    HGNC: 14248

    OMIM: 607372

    KEGG: hsa:51586

    STRING: 9606.ENSP00000263205

    UniGene: Hs.517421



主站蜘蛛池模板： 羞羞视频在线观看| 国产真实交换配乱婬95视频| 中文字幕乱码人妻一区二区三区| 女人被弄到高潮的免费视频| 成人国产mv免费视频| 欧美日激情日韩精品嗯| 婷婷激情综合色五月久久竹菊影视| 国产69精品久久久久乱码韩国| 国模杨依粉嫩蝴蝶150p| 色狠狠成人综合网| 天天av天天爽无码中文| 国产农村乱人伦精品视频| 国产免费人成在线视频app| 小污女导航福利入口| 国产乱人伦精品免费| 苍井空张开腿实干12次| 中文字幕日本最新乱码视频| 狼群社区www中文视频| 色综合a怡红院怡红院| 99精品国产一区二区三区不卡 | 亚洲中文字幕无码天然素人| 国产精品专区免费观看软件 | 免费中文字幕日韩欧美| 日日噜噜夜夜狠狠久久丁香五月 | 国产成人av免费观看| 激情综合色五月六月婷婷 | 婷婷激情综合色五月久久竹菊影视| 国产玉足榨精视频在线观看 | 国产精品视频一区二区三区不卡 | 日产亚洲一区二区三区| 免费视频国产在线观看| 精品无码一区二区三区的天堂| 欧美丰满熟妇xx猛交| 少妇人妻精品一区二区| 99精品丰满人妻无码a片| 欧美成人午夜免费影院手机在线看 | 久久99精品国产免费观观| 成在线人视频免费视频| 国产精品无码一区二区桃花视频| 免费无码av片在线观看潮喷 | 成人午夜亚洲精品无码区|