在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MCM4 Antibody, FITC conjugated

  • 中文名稱:
    MCM4兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA013594LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MCM4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    19G antibody; AI325074 antibody; AU045576 antibody; CDC 21 antibody; CDC 54 antibody; CDC21 antibody; CDC21 homolog antibody; CDC21, S. pombe, homolog of antibody; CDC54 antibody; Cell division cycle 21, S. pombe, homolog of antibody; DNA replication licensing factor MCM 4 antibody; DNA replication licensing factor MCM4 antibody; hCdc 21 antibody; hCdc21 antibody; Homolog of S. pombe cell devision cycle 21 antibody; KIAA4003 antibody; mcdc21 antibody; MCM 4 antibody; MCM 4 minichromosome maintenance deficient 4 antibody; mcm4 antibody; MCM4 minichromosome maintenance deficient 4 antibody; MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) antibody; MCM4_HUMAN antibody; Mcmd4 antibody; MGC33310 antibody; Minichromosome maintenance 4 antibody; Minichromosome maintenance complex component 4 antibody; Minichromosome maintenance deficient (S. cerevisiae) 4 antibody; Minichromosome maintenance deficient 4 antibody; Minichromosome maintenance deficient 4 homolog (S. cerevisiae) antibody; Minichromosome maintenance, S. cerevisiae, homolog of, 4 antibody; mKIAA4003 antibody; NKCD antibody; NKGCD antibody; P1 CDC21 antibody; P1-CDC21 antibody; P1CDC21 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DNA replication licensing factor MCM4 protein (2-141AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
  • 基因功能參考文獻:
    1. MCM4 and MCM7 expression is significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions. PMID: 27476776
    2. This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded. PMID: 27794528
    3. We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin PMID: 26188903
    4. Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4 PMID: 25661590
    5. Mutant p53 depletion profoundly influenced PARP1 localization and increased the level of PCNA and MCM4 proteins. PMID: 25733866
    6. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells PMID: 23264620
    7. point mutation of MCM4 perturbs proper interaction with MCM6 to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 complex PMID: 22668557
    8. Mutations in MCM4/PRKDC represent a novel cause of DNA breakage and NK cell deficiency. PMID: 22499342
    9. Widdrol breaks DNA directly in HT29 cells, resulting in checkpoint activation via Chk2-p53-Cdc25A-p21-MCM4 pathway and finally cells go to G1-phase cell cycle arrest and apoptosis. PMID: 22160829
    10. partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency PMID: 22354167
    11. MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency PMID: 22354170
    12. higher expression in non-small cell lung cancer PMID: 20884074
    13. MCM4 did not predict patient survival in this series of cutaneous melanomas. PMID: 20398247
    14. the phosphorylation of MCM4 in the checkpoint control inhibits DNA replication, which includes blockage of DNA fork progression, through inactivation of the MCM complex PMID: 12714602
    15. HU- or UV irradiation-stimulated phosphorylation of MCM4 at several CDK sites led to inhibition of MCM4 helicase activity, consistent with the notion that the phosphorylation of MCM4 is involved in regulation of DNA synthesis in the checkpoint control. PMID: 15037254
    16. These results suggest that phosphorylation of MCM4 has several distinct and site-specific roles in the function of MCM during the mammalian cell cycle. PMID: 16519687
    17. Expression of EBV-protein kinase caused phosphorylation of Thr-19 & Thr-110 on MCM4 PMID: 17005684
    18. MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin PMID: 17046832
    19. The positive rate of MCM4 was significantly higher in stage T3 than in stage T1 esophageal cancer. PMID: 17222376
    20. Data show that two fragments (148-441 and 442-676) from the central region of MCM2 were mainly responsible for the interaction between MCM2 and MCM4, and this was revealed by a pulldown analysis using MCM4 protein beads. PMID: 18190532
    21. Sequence alignment of archaeal MCMs and MCM4 from Homo sapiens and Saccharomyces cerevisiae shows that Aeropyrum pernix MCM shares 32% identity with human and yeast MCM4. PMID: 19053250

    顯示更多

    收起更多

  • 相關疾病:
    Natural killer cell and glucocorticoid deficiency with DNA repair defect (NKGCD)
  • 亞細胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    MCM family
  • 數據庫鏈接:

    HGNC: 6947

    OMIM: 602638

    KEGG: hsa:4173

    STRING: 9606.ENSP00000262105

    UniGene: Hs.460184



主站蜘蛛池模板: 精品国产福利在线视频| 国产成人精品一区二三区| 亚洲成av人片在www色猫咪| 亚洲精品蜜夜内射| 国产精品亚洲一区二区无码| 在线岛国片免费无码av| 久久99国产综合精品女同| 夜夜躁狠狠躁日日躁2022| 无码高潮少妇毛多水多水| 午夜福利理论片在线观看播放| 国产人妻鲁鲁一区二区| 成人爽a毛片免费看| 国产精品第一区揄拍无码| 国产人碰人摸人爱免费视频| 国模冰莲极品自慰人体| 中文字幕av伊人av无码av| 国产精品自在线一区| 欧精国精产品一区| 亚洲综合无码一区二区三区| 色先锋资源久久综合5566| 欧美另类又黄又爽的a片| 国产精品久久久久久52avav| 97在线视频人妻无码| 女人被狂爆到高潮免费视频| 亚洲男人的天堂成人www| 亚洲欧美乱综合图片区小说区 | 天堂资源在线www中文| 黑人猛挺进小莹的体内视频| 日本真人边吃奶边做爽免费视频| 亚洲精品国产第一综合99久久| 国产思思99re99在线观看| 日韩在线视频线观看一区| 人人狠狠综合久久亚洲爱咲 | 国产96在线 | 韩国| 亚洲成av 人片在线观看无码| 99精品国产一区二区三区不卡| 人妻少妇精品中文字幕av| 国产极品美女到高潮无套| 亚洲第一在线综合网站| 乌克兰少妇xxxx做受| 国产又色又爽又黄的|