在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MCM4 Antibody, Biotin conjugated

  • 中文名稱:
    MCM4兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA013594LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MCM4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    19G antibody; AI325074 antibody; AU045576 antibody; CDC 21 antibody; CDC 54 antibody; CDC21 antibody; CDC21 homolog antibody; CDC21, S. pombe, homolog of antibody; CDC54 antibody; Cell division cycle 21, S. pombe, homolog of antibody; DNA replication licensing factor MCM 4 antibody; DNA replication licensing factor MCM4 antibody; hCdc 21 antibody; hCdc21 antibody; Homolog of S. pombe cell devision cycle 21 antibody; KIAA4003 antibody; mcdc21 antibody; MCM 4 antibody; MCM 4 minichromosome maintenance deficient 4 antibody; mcm4 antibody; MCM4 minichromosome maintenance deficient 4 antibody; MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) antibody; MCM4_HUMAN antibody; Mcmd4 antibody; MGC33310 antibody; Minichromosome maintenance 4 antibody; Minichromosome maintenance complex component 4 antibody; Minichromosome maintenance deficient (S. cerevisiae) 4 antibody; Minichromosome maintenance deficient 4 antibody; Minichromosome maintenance deficient 4 homolog (S. cerevisiae) antibody; Minichromosome maintenance, S. cerevisiae, homolog of, 4 antibody; mKIAA4003 antibody; NKCD antibody; NKGCD antibody; P1 CDC21 antibody; P1-CDC21 antibody; P1CDC21 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human DNA replication licensing factor MCM4 protein (2-141AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
  • 基因功能參考文獻(xiàn):
    1. MCM4 and MCM7 expression is significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions. PMID: 27476776
    2. This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded. PMID: 27794528
    3. We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin PMID: 26188903
    4. Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4 PMID: 25661590
    5. Mutant p53 depletion profoundly influenced PARP1 localization and increased the level of PCNA and MCM4 proteins. PMID: 25733866
    6. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells PMID: 23264620
    7. point mutation of MCM4 perturbs proper interaction with MCM6 to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 complex PMID: 22668557
    8. Mutations in MCM4/PRKDC represent a novel cause of DNA breakage and NK cell deficiency. PMID: 22499342
    9. Widdrol breaks DNA directly in HT29 cells, resulting in checkpoint activation via Chk2-p53-Cdc25A-p21-MCM4 pathway and finally cells go to G1-phase cell cycle arrest and apoptosis. PMID: 22160829
    10. partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency PMID: 22354167
    11. MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency PMID: 22354170
    12. higher expression in non-small cell lung cancer PMID: 20884074
    13. MCM4 did not predict patient survival in this series of cutaneous melanomas. PMID: 20398247
    14. the phosphorylation of MCM4 in the checkpoint control inhibits DNA replication, which includes blockage of DNA fork progression, through inactivation of the MCM complex PMID: 12714602
    15. HU- or UV irradiation-stimulated phosphorylation of MCM4 at several CDK sites led to inhibition of MCM4 helicase activity, consistent with the notion that the phosphorylation of MCM4 is involved in regulation of DNA synthesis in the checkpoint control. PMID: 15037254
    16. These results suggest that phosphorylation of MCM4 has several distinct and site-specific roles in the function of MCM during the mammalian cell cycle. PMID: 16519687
    17. Expression of EBV-protein kinase caused phosphorylation of Thr-19 & Thr-110 on MCM4 PMID: 17005684
    18. MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin PMID: 17046832
    19. The positive rate of MCM4 was significantly higher in stage T3 than in stage T1 esophageal cancer. PMID: 17222376
    20. Data show that two fragments (148-441 and 442-676) from the central region of MCM2 were mainly responsible for the interaction between MCM2 and MCM4, and this was revealed by a pulldown analysis using MCM4 protein beads. PMID: 18190532
    21. Sequence alignment of archaeal MCMs and MCM4 from Homo sapiens and Saccharomyces cerevisiae shows that Aeropyrum pernix MCM shares 32% identity with human and yeast MCM4. PMID: 19053250

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Natural killer cell and glucocorticoid deficiency with DNA repair defect (NKGCD)
  • 亞細(xì)胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    MCM family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6947

    OMIM: 602638

    KEGG: hsa:4173

    STRING: 9606.ENSP00000262105

    UniGene: Hs.460184



主站蜘蛛池模板: 免费男人下部进女人下部视频| 一区二区国产高清视频在线| 国产精品亚洲lv粉色| 免费观看性行为视频的网站| 亚洲 日韩 欧美 成人 在线| 爆乳喷奶水无码正在播放| 熟妇无码乱子成人精品| 亚洲成a人片在线观看中文| 亚洲制服丝袜av一区二区三区| 国产美女视频免费观看网址| 久热国产精品视频一区二区三区| 蜜臀av人妻国产精品建身房| 亚洲精品国产精品制服丝袜| 欧美伦费免费全部午夜最新| 国产亚洲美女精品久久久2020| 久久人人爽人人爽人人片av麻烦| 国产第一页浮力影院入口 | 婷婷五月综合激情中文字幕| 超清制服丝袜无码av福利网| 欧美放荡的少妇| av色欲无码人妻中文字幕| 日韩精品人妻系列一区二区三区 | 中文在线天堂а√在线| 无码国产精品一区二区高潮| 亚洲有无码av在线播放| 日韩av高潮喷水在线观看| 老色鬼永久精品网站| 日本japanese丰满白浆| 成人片黄网站a毛片免费观看| 狠狠色噜噜狠狠狠狠五月婷| 无码137片内射在线影院| 欧美亚洲国产精品久久蜜芽| 国产成人精品日本亚洲999| 精品久久久无码中文字幕 | 亚洲欧美中文高清在线专区 | 精品国产一区二区三区麻豆| 亚洲欧洲日本综合aⅴ在线| 无码aⅴ精品一区二区三区浪潮 | 久久国产劲爆∧v内射| 国产无遮挡又爽又黄大胸免费| 羞国产在线拍揄自揄视频|